Neuroimaging and epigenetic analysis reveal novel epigenetic loci in major depressive disorder

Epigenetic modifications, such as DNA methylation, contribute to the pathophysiology of major depressive disorder (MDD). This study aimed to identify novel MDD-associated epigenetic loci using DNA methylation profiles and explore the correlations between epigenetic loci and cortical thickness change...

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Veröffentlicht in:	Psychological medicine 2024-07, Vol.54 (10), p.2585-2598
Hauptverfasser:	Yang, Hyun-Ho, Han, Kyu-Man, Kim, Aram, Kang, Youbin, Tae, Woo-Suk, Han, Mi-Ryung, Ham, Byung-Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Blood Brain Case-Control Studies Central nervous system Copy number Correlation analysis Cortex Deoxyribonucleic acid Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - genetics Depressive personality disorders DNA DNA Methylation DNA probes Epigenesis, Genetic Epigenetics Female Genes Genome-Wide Association Study Humans Image processing Leukocytes Magnetic Resonance Imaging Male Medical imaging Mental depression Mental disorders Middle Aged Nervous system Neurobiology Neuroimaging Occipital lobe Pathophysiology Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - pathology Psychiatrists Statistical power
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