GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy

The tumor microenvironment presents many obstacles to effective chimeric antigen receptor (CAR) T cell therapy, including glucose competition from tumor and myeloid cells. Using mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM), we show that enfor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular therapy 2024-07, Vol.32 (7), p.2393-2405
Hauptverfasser:	Shi, Yuzhe, Kotchetkov, Ivan S., Dobrin, Anton, Hanina, Sophie A., Rajasekhar, Vinagolu K., Healey, John H., Sadelain, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal glioblastoma Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism GLUT3 glycolysis, oxidative phosphorylation, metabolism Humans Immunotherapy, Adoptive - methods leukemia Mice Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - metabolism renal cell carcinoma T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Microenvironment - immunology Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!