Disseminated Histoplasmosis presenting with panniculitis and macrophage activation syndrome in a patient undergoing immunosuppressive therapy for Mixed Connective Tissue Disease (MCTD)
Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this is not common in Japan. We herein present a unique case of military histoplasmosis in a 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosup...
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| Veröffentlicht in: | Internal Medicine 2024, pp.3597-24 |
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| container_start_page | 3597-24 |
| container_title | Internal Medicine |
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| creator | Kawashima, Hirotoshi Saku, Aiko Konishi, Mai Hayashi, Yuichiro Watanabe, Akira Hirose, Koichi |
| description | Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this is not common in Japan. We herein present a unique case of military histoplasmosis in a 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosuppressive therapy. The histological findings coupled with molecular confirmation led to final a diagnosis. This case emphasizes the diagnostic challenges associated with histoplasmosis in immunocompromised patients and underscores the importance of considering it in the differential diagnosis of any atypical presentation in rheumatic patients. |
| doi_str_mv | 10.2169/internalmedicine.3597-24 |
| format | Article |
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Med.</addtitle><date>2025-01-01</date><risdate>2025</risdate><volume>64</volume><issue>1</issue><spage>3597-24</spage><epage>146</epage><pages>3597-24-146</pages><artnum>3597-24</artnum><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this is not common in Japan. We herein present a unique case of military histoplasmosis in a 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosuppressive therapy. The histological findings coupled with molecular confirmation led to final a diagnosis. 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| ispartof | Internal Medicine, 2024, pp.3597-24 |
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| language | eng |
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| source | J-STAGE (Free - Japanese); PubMed Central; PubMed Central Open Access |
| subjects | Cell activation Connective tissue diseases Differential diagnosis fungal ITS sequence Histoplasmosis Immunocompromised hosts Immunosuppressive agents Macrophages MCTD Mixed connective tissue disease |
| title | Disseminated Histoplasmosis presenting with panniculitis and macrophage activation syndrome in a patient undergoing immunosuppressive therapy for Mixed Connective Tissue Disease (MCTD) |
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