Early matrix softening contributes to vascular smooth muscle cell phenotype switching and aortic dissection through down-regulation of microRNA-143/145

Thoracic aortic dissection (TAD) is characterized by extracellular matrix (ECM) dysregulation. Aberrations in the ECM stiffness can lead to changes in cellular functions. However, the mechanism by which ECM softening regulates vascular smooth muscle cell (VSMCs) phenotype switching remains unclear....

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2024-07, Vol.192, p.1-12
Hauptverfasser:	Ye, Zhaofei, Zhu, Shuolin, Li, Guoqi, Lu, Jie, Huang, Shan, Du, Jie, Shao, Yihui, Ji, Zhili, Li, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Extracellular matrix miR-143/145 Synthetic phenotype Thoracic aortic dissection Vascular smooth muscle cell
Online-Zugang:	Volltext
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