Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish
Organophosphate esters (OPEs) have been demonstrated to induce various forms of toxicity in aquatic organisms. However, a scarcity of evidence impedes the conclusive determination of whether OPEs manifest sex-dependent toxic effects. Here, we investigated the effects of tris (1-chloro-2-propyl) phos...
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Veröffentlicht in: | The Science of the total environment 2024-07, Vol.932, p.172892-172892, Article 172892 |
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description | Organophosphate esters (OPEs) have been demonstrated to induce various forms of toxicity in aquatic organisms. However, a scarcity of evidence impedes the conclusive determination of whether OPEs manifest sex-dependent toxic effects. Here, we investigated the effects of tris (1-chloro-2-propyl) phosphate (TCPP) and resorcinol bis (diphenyl phosphate) (RDP) on the intestines of both female and male zebrafish. The results indicated that, in comparison to TCPP, RDP induced more pronounced intestinal microstructural damage and oxidative stress, particularly in male zebrafish. 16S rRNA sequencing and metabolomics revealed significant alterations in the species richness and oxidative stress-related metabolites in the intestinal microbiota of zebrafish under exposure to both TCPP and RDP, manifesting gender-specific effects. Based on differential species analysis, we defined invasive species and applied invasion theory to analyze the reasons for changes in the male fish intestinal community. Correlation analysis demonstrated that alien species may have potential effects on metabolism. Overall, this study reveals a pronounced gender-dependent impact on both the intestinal microbiota and metabolic disruptions of zebrafish due to OPEs exposure and offers a novel perspective on the influence of pollutants on intestinal microbial communities and metabolism.
[Display omitted]
•More severe effects on intestinal flora and metabolism of male zebrafish under RDP exposure•The intestinal flora and metabolism of zebrafish showed a sex-dependent response to OPEs.•RDP exposure causes alien species to colonize the intestines of male zebrafish.•Alien species may have potential effects on intestinal flora and metabolism. |
doi_str_mv | 10.1016/j.scitotenv.2024.172892 |
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[Display omitted]
•More severe effects on intestinal flora and metabolism of male zebrafish under RDP exposure•The intestinal flora and metabolism of zebrafish showed a sex-dependent response to OPEs.•RDP exposure causes alien species to colonize the intestines of male zebrafish.•Alien species may have potential effects on intestinal flora and metabolism.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2024.172892</identifier><identifier>PMID: 38719053</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Female ; Gastrointestinal Microbiome - drug effects ; Male ; Metabolism ; Organophosphate esters ; Oxidative Stress - drug effects ; Resorcinols - toxicity ; RNA, Ribosomal, 16S ; Sex-dependent toxicity ; Water Pollutants, Chemical - toxicity ; Zebrafish</subject><ispartof>The Science of the total environment, 2024-07, Vol.932, p.172892-172892, Article 172892</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c317t-f1d89fbc5eabb15ff3ec61cd633a4009daa79a970434417fb0877b80ac7848cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2024.172892$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38719053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xinwei</creatorcontrib><creatorcontrib>Lu, Ting</creatorcontrib><creatorcontrib>Yang, Bin</creatorcontrib><creatorcontrib>Cao, Jing</creatorcontrib><creatorcontrib>Li, Mei</creatorcontrib><title>Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Organophosphate esters (OPEs) have been demonstrated to induce various forms of toxicity in aquatic organisms. However, a scarcity of evidence impedes the conclusive determination of whether OPEs manifest sex-dependent toxic effects. Here, we investigated the effects of tris (1-chloro-2-propyl) phosphate (TCPP) and resorcinol bis (diphenyl phosphate) (RDP) on the intestines of both female and male zebrafish. The results indicated that, in comparison to TCPP, RDP induced more pronounced intestinal microstructural damage and oxidative stress, particularly in male zebrafish. 16S rRNA sequencing and metabolomics revealed significant alterations in the species richness and oxidative stress-related metabolites in the intestinal microbiota of zebrafish under exposure to both TCPP and RDP, manifesting gender-specific effects. Based on differential species analysis, we defined invasive species and applied invasion theory to analyze the reasons for changes in the male fish intestinal community. Correlation analysis demonstrated that alien species may have potential effects on metabolism. Overall, this study reveals a pronounced gender-dependent impact on both the intestinal microbiota and metabolic disruptions of zebrafish due to OPEs exposure and offers a novel perspective on the influence of pollutants on intestinal microbial communities and metabolism.
[Display omitted]
•More severe effects on intestinal flora and metabolism of male zebrafish under RDP exposure•The intestinal flora and metabolism of zebrafish showed a sex-dependent response to OPEs.•RDP exposure causes alien species to colonize the intestines of male zebrafish.•Alien species may have potential effects on intestinal flora and metabolism.</description><subject>Animals</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Male</subject><subject>Metabolism</subject><subject>Organophosphate esters</subject><subject>Oxidative Stress - drug effects</subject><subject>Resorcinols - toxicity</subject><subject>RNA, Ribosomal, 16S</subject><subject>Sex-dependent toxicity</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Zebrafish</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhiMEoofCK4CXZZGDHefEzrKqykWqxAbWli-TZo4cO9hOoX0uHpAcUrplNrP5_38uX1W9Y3TPKOs-HPfZYokFwt2-oU27Z6KRffOs2jEp-prRpnte7ShtZd13vTirXuV8pGsJyV5WZ1wK1tMD31W_r3_NMS8JSIkkQY7JYoieGMzkwuE8Qrj3ZB5jnkdd4D3B4BYLmdjoY8AHXTAGEgeiPUIgE9oUY7rVAfOUyU8sI5lPaxbUnuA0a1syWR1lBHK7lM1gMBZNdHBkgqJN9GiJw5yW-W86rrnaA3kAk_SAeXxdvRi0z_DmsZ9X3z9ef7v6XN98_fTl6vKmtpyJUg_MyX4w9gDaGHYYBg62Y9Z1nOuW0t5pLXrdC9rytmViMFQKYSTVVshWWsfPq4std07xxwK5qAmzBe91gLhkxdcXMt6KVq5SsUnXc3JOMKg54aTTvWJUnZCpo3pCpk7I1IZsdb59HLKYCdyT7x-jVXC5CWA99Q4hnYIgWHCYwBblIv53yB-3LLKb</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Wang, Xinwei</creator><creator>Lu, Ting</creator><creator>Yang, Bin</creator><creator>Cao, Jing</creator><creator>Li, Mei</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240701</creationdate><title>Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish</title><author>Wang, Xinwei ; Lu, Ting ; Yang, Bin ; Cao, Jing ; Li, Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-f1d89fbc5eabb15ff3ec61cd633a4009daa79a970434417fb0877b80ac7848cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Female</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Male</topic><topic>Metabolism</topic><topic>Organophosphate esters</topic><topic>Oxidative Stress - drug effects</topic><topic>Resorcinols - toxicity</topic><topic>RNA, Ribosomal, 16S</topic><topic>Sex-dependent toxicity</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xinwei</creatorcontrib><creatorcontrib>Lu, Ting</creatorcontrib><creatorcontrib>Yang, Bin</creatorcontrib><creatorcontrib>Cao, Jing</creatorcontrib><creatorcontrib>Li, Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xinwei</au><au>Lu, Ting</au><au>Yang, Bin</au><au>Cao, Jing</au><au>Li, Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>932</volume><spage>172892</spage><epage>172892</epage><pages>172892-172892</pages><artnum>172892</artnum><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Organophosphate esters (OPEs) have been demonstrated to induce various forms of toxicity in aquatic organisms. However, a scarcity of evidence impedes the conclusive determination of whether OPEs manifest sex-dependent toxic effects. Here, we investigated the effects of tris (1-chloro-2-propyl) phosphate (TCPP) and resorcinol bis (diphenyl phosphate) (RDP) on the intestines of both female and male zebrafish. The results indicated that, in comparison to TCPP, RDP induced more pronounced intestinal microstructural damage and oxidative stress, particularly in male zebrafish. 16S rRNA sequencing and metabolomics revealed significant alterations in the species richness and oxidative stress-related metabolites in the intestinal microbiota of zebrafish under exposure to both TCPP and RDP, manifesting gender-specific effects. Based on differential species analysis, we defined invasive species and applied invasion theory to analyze the reasons for changes in the male fish intestinal community. Correlation analysis demonstrated that alien species may have potential effects on metabolism. Overall, this study reveals a pronounced gender-dependent impact on both the intestinal microbiota and metabolic disruptions of zebrafish due to OPEs exposure and offers a novel perspective on the influence of pollutants on intestinal microbial communities and metabolism.
[Display omitted]
•More severe effects on intestinal flora and metabolism of male zebrafish under RDP exposure•The intestinal flora and metabolism of zebrafish showed a sex-dependent response to OPEs.•RDP exposure causes alien species to colonize the intestines of male zebrafish.•Alien species may have potential effects on intestinal flora and metabolism.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38719053</pmid><doi>10.1016/j.scitotenv.2024.172892</doi><tpages>1</tpages></addata></record> |
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subjects | Animals Female Gastrointestinal Microbiome - drug effects Male Metabolism Organophosphate esters Oxidative Stress - drug effects Resorcinols - toxicity RNA, Ribosomal, 16S Sex-dependent toxicity Water Pollutants, Chemical - toxicity Zebrafish |
title | Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish |
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