The role of IGFBP-3 in tumor development and progression: enlightenment for diagnosis and treatment

IGFBP-3 is aberrantly expressed in many tumor types, and its serum and tumor tissue levels provide auxiliary information for assessing the degree of tumor malignancy and patient prognosis, making it a potential therapeutic target for human malignancies and conferring it remarkable clinical value for...

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Veröffentlicht in:Medical oncology (Northwood, London, England) London, England), 2024-05, Vol.41 (6), p.141, Article 141
Hauptverfasser: Wang, Yudi, Zhang, He, Zhang, Xuehua, Mu, Peizheng, Zhao, Leilei, Qi, Ruomei, Zhang, Yurui, Zhu, Xiao, Dong, Yucui
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Sprache:eng
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Zusammenfassung:IGFBP-3 is aberrantly expressed in many tumor types, and its serum and tumor tissue levels provide auxiliary information for assessing the degree of tumor malignancy and patient prognosis, making it a potential therapeutic target for human malignancies and conferring it remarkable clinical value for determining patient prognosis. In this review, we provide a comprehensive overview of the aberrant expression, diverse biological effects, and clinical implications of IGFBP-3 in tumors and its role as a potential prognostic marker and therapeutic target for tumors. In addition, we summarize the signaling pathways through which IGFBP-3 exerts its effects. IGFBP-3 comprises an N-terminal, an intermediate region, and a C-terminal structural domain, each exerting different biological effects in several tumor cell types in an IGF-dependent/non-independent manner. IGFBP-3 shares an intricate relationship with the tumor microenvironment, thereby affecting tumor growth. Overall, IGFBP-3 is an essential regulatory factor that mediates tumor occurrence and progression. Gaining deeper insights into the fundamental characteristics of IGFBP-3 and its role in various tumor types will provide new perspectives and allow for the development of novel strategies for cancer diagnosis, treatment, and prognostic evaluation.
ISSN:1559-131X
1357-0560
1559-131X
DOI:10.1007/s12032-024-02373-x