3D printing-based lateral flow visual assay utilizing the dual-excitation property of nitrogen-doped carbon dots for the ratiometric determination and chemometric discrimination of flavonoids
A ratiometric fluorescence sensor has been established based on dual-excitation carbon dots (D-CDs) for the detection of flavonoids (morin is chosen as the typical detecting model for flavonoids). D-CDs were prepared using microwave radiation with o-phenylenediamine and melamine and exhibit controll...
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Veröffentlicht in: | Mikrochimica acta (1966) 2024-06, Vol.191 (6), p.310-310, Article 310 |
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creator | Ma, Danhua Zhang, Ting Xing, Haoming Wang, Linfan Chen, Da Wang, Liang |
description | A ratiometric fluorescence sensor has been established based on dual-excitation carbon dots (D-CDs) for the detection of flavonoids (morin is chosen as the typical detecting model for flavonoids). D-CDs were prepared using microwave radiation with o-phenylenediamine and melamine and exhibit controllable dual-excitation behavior through the regulation of their concentration. Remarkably, the short-wavelength excitation of D-CDs can be quenched by morin owing to the inner filter effect, while the long-wavelength excitation remains insensitive, serving as the reference signal. This contributes to the successful design of an excitation-based ratiometric sensor. Based on the distinct and differentiated variation of excitation intensity, morin can be determined from 0.156 to 110 µM with a low detection limit of 0.156 µM. In addition, an intelligent and visually lateral flow sensing device is developed for the determination of morin content in real samples with satisfying recoveries, which indicates the potential application for human health monitoring.
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doi_str_mv | 10.1007/s00604-024-06383-4 |
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Graphical Abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-024-06383-4</identifier><identifier>PMID: 38714566</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Carbon - chemistry ; Carbon dots ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Controllability ; Excitation ; Flavones ; Flavonoids ; Flavonoids - analysis ; Flavonoids - chemistry ; Fluorescent Dyes - chemistry ; Humans ; Limit of Detection ; Melamine ; Microengineering ; Microwaves ; Nanochemistry ; Nanotechnology ; Nitrogen - chemistry ; Original Paper ; Phenylenediamine ; Printing, Three-Dimensional ; Quantum Dots - chemistry ; Reference signals ; Spectrometry, Fluorescence - methods ; Three dimensional flow ; Three dimensional printing</subject><ispartof>Mikrochimica acta (1966), 2024-06, Vol.191 (6), p.310-310, Article 310</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-ecdfe03620c0b91e6e09645cdacde942738b4becd9477fcbb89bc92bbf8b15b73</cites><orcidid>0000-0002-0334-9502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-024-06383-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-024-06383-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38714566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Danhua</creatorcontrib><creatorcontrib>Zhang, Ting</creatorcontrib><creatorcontrib>Xing, Haoming</creatorcontrib><creatorcontrib>Wang, Linfan</creatorcontrib><creatorcontrib>Chen, Da</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><title>3D printing-based lateral flow visual assay utilizing the dual-excitation property of nitrogen-doped carbon dots for the ratiometric determination and chemometric discrimination of flavonoids</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>A ratiometric fluorescence sensor has been established based on dual-excitation carbon dots (D-CDs) for the detection of flavonoids (morin is chosen as the typical detecting model for flavonoids). D-CDs were prepared using microwave radiation with o-phenylenediamine and melamine and exhibit controllable dual-excitation behavior through the regulation of their concentration. Remarkably, the short-wavelength excitation of D-CDs can be quenched by morin owing to the inner filter effect, while the long-wavelength excitation remains insensitive, serving as the reference signal. This contributes to the successful design of an excitation-based ratiometric sensor. Based on the distinct and differentiated variation of excitation intensity, morin can be determined from 0.156 to 110 µM with a low detection limit of 0.156 µM. In addition, an intelligent and visually lateral flow sensing device is developed for the determination of morin content in real samples with satisfying recoveries, which indicates the potential application for human health monitoring.
Graphical Abstract</description><subject>Analytical Chemistry</subject><subject>Carbon - chemistry</subject><subject>Carbon dots</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Controllability</subject><subject>Excitation</subject><subject>Flavones</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Flavonoids - chemistry</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Humans</subject><subject>Limit of Detection</subject><subject>Melamine</subject><subject>Microengineering</subject><subject>Microwaves</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Nitrogen - chemistry</subject><subject>Original Paper</subject><subject>Phenylenediamine</subject><subject>Printing, Three-Dimensional</subject><subject>Quantum Dots - chemistry</subject><subject>Reference signals</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>Three dimensional flow</subject><subject>Three dimensional printing</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIkPgB1ggS2zYGPzodncvUXhKkdjAuuVH9cRRtx1sd8Lwc_waNTNhkFiwsGxVnXurrEvIc8FfC867N4VzzRvGJR6tesWaB2QjGqVZyzv1kGw4l5op3ckz8qSUa85Fp2XzmJypvhNNq_WG_FLv6E0OsYa4ZdYU8HQ2FbKZ6TSnO3obyopvU4rZ0bWGOfxEktYroB4bDH64UE0NKaJNuoFcdzRNNIaa0xYi81jz1JlskfCpFjqlfJDnvWqBmoOjHnDkEuLRyERUXMFy6obicji10X6azW2KKfjylDyazFzg2f19Tr59eP_14hO7_PLx88XbS-aU1JWB8xNwpSV33A4CNPBBN63zxnkYGtmp3jYWqaHpuslZ2w_WDdLaqbeitZ06J6-OvvjL7yuUOi64FcyziZDWMireynbQsheIvvwHvU5rjrjdgeK9kK1CSh4pl1MpGaYRY1hM3o2Cj_t4x2O8I8Y7HuIdGxS9uLde7QL-JPmTJwLqCJR9qFvIf2f_x_Y3rZS2mQ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Ma, Danhua</creator><creator>Zhang, Ting</creator><creator>Xing, Haoming</creator><creator>Wang, Linfan</creator><creator>Chen, Da</creator><creator>Wang, Liang</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0334-9502</orcidid></search><sort><creationdate>20240601</creationdate><title>3D printing-based lateral flow visual assay utilizing the dual-excitation property of nitrogen-doped carbon dots for the ratiometric determination and chemometric discrimination of flavonoids</title><author>Ma, Danhua ; Zhang, Ting ; Xing, Haoming ; Wang, Linfan ; Chen, Da ; Wang, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-ecdfe03620c0b91e6e09645cdacde942738b4becd9477fcbb89bc92bbf8b15b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analytical Chemistry</topic><topic>Carbon - chemistry</topic><topic>Carbon dots</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Controllability</topic><topic>Excitation</topic><topic>Flavones</topic><topic>Flavonoids</topic><topic>Flavonoids - analysis</topic><topic>Flavonoids - chemistry</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Humans</topic><topic>Limit of Detection</topic><topic>Melamine</topic><topic>Microengineering</topic><topic>Microwaves</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Nitrogen - chemistry</topic><topic>Original Paper</topic><topic>Phenylenediamine</topic><topic>Printing, Three-Dimensional</topic><topic>Quantum Dots - chemistry</topic><topic>Reference signals</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>Three dimensional flow</topic><topic>Three dimensional printing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Danhua</creatorcontrib><creatorcontrib>Zhang, Ting</creatorcontrib><creatorcontrib>Xing, Haoming</creatorcontrib><creatorcontrib>Wang, Linfan</creatorcontrib><creatorcontrib>Chen, Da</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Danhua</au><au>Zhang, Ting</au><au>Xing, Haoming</au><au>Wang, Linfan</au><au>Chen, Da</au><au>Wang, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D printing-based lateral flow visual assay utilizing the dual-excitation property of nitrogen-doped carbon dots for the ratiometric determination and chemometric discrimination of flavonoids</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>191</volume><issue>6</issue><spage>310</spage><epage>310</epage><pages>310-310</pages><artnum>310</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>A ratiometric fluorescence sensor has been established based on dual-excitation carbon dots (D-CDs) for the detection of flavonoids (morin is chosen as the typical detecting model for flavonoids). D-CDs were prepared using microwave radiation with o-phenylenediamine and melamine and exhibit controllable dual-excitation behavior through the regulation of their concentration. Remarkably, the short-wavelength excitation of D-CDs can be quenched by morin owing to the inner filter effect, while the long-wavelength excitation remains insensitive, serving as the reference signal. This contributes to the successful design of an excitation-based ratiometric sensor. Based on the distinct and differentiated variation of excitation intensity, morin can be determined from 0.156 to 110 µM with a low detection limit of 0.156 µM. In addition, an intelligent and visually lateral flow sensing device is developed for the determination of morin content in real samples with satisfying recoveries, which indicates the potential application for human health monitoring.
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subjects | Analytical Chemistry Carbon - chemistry Carbon dots Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Controllability Excitation Flavones Flavonoids Flavonoids - analysis Flavonoids - chemistry Fluorescent Dyes - chemistry Humans Limit of Detection Melamine Microengineering Microwaves Nanochemistry Nanotechnology Nitrogen - chemistry Original Paper Phenylenediamine Printing, Three-Dimensional Quantum Dots - chemistry Reference signals Spectrometry, Fluorescence - methods Three dimensional flow Three dimensional printing |
title | 3D printing-based lateral flow visual assay utilizing the dual-excitation property of nitrogen-doped carbon dots for the ratiometric determination and chemometric discrimination of flavonoids |
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