Opioid analgesic exposure during the first trimester of pregnancy and the risk of major congenital malformations in infants: a systematic review and meta-analysis

Prescribed opioid analgesics are frequently used to manage pain in pregnancy. However, the available literature regarding the teratogenic potential of opioid use during pregnancy has not been systematically summarised. This systematic review and meta-analysis aimed to assess the quality of the evide...

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Veröffentlicht in:	Anaesthesia 2024-09, Vol.79 (9), p.967-977
Hauptverfasser:	Varney, Bianca, Brett, Jonathan, Zoega, Helga, Gillies, Malcolm B, Powell, Madeline, Bateman, Brian T, Shand, Antonia W, Pearson, Sallie-Anne, Havard, Alys
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - epidemiology Abnormalities, Drug-Induced - etiology Analgesics Analgesics, Opioid - adverse effects Bias Cardiovascular diseases Central nervous system Cleft lip/palate Codeine Congenital defects Estimates Exposure Female Humans Infant, Newborn Infants Meta-analysis Narcotics Opioids Pregnancy Pregnancy Complications - drug therapy Pregnancy Trimester, First Prenatal Exposure Delayed Effects Risk analysis Risk assessment Risk management Systematic review Teratogenicity Uncertainty analysis
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