An NMR Toolkit to Probe Amyloid Oligomer Inhibition in Neurodegenerative Diseases: From Ligand Screening to Dissecting Binding Topology and Mechanisms of Action

The aggregation of amyloid peptides and proteins into toxic oligomers is a hallmark of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Machado‐Joseph's disease, and transmissible spongiform encephalopathies. Inhibition of amyloid oligomers formation and i...

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Veröffentlicht in:	ChemPlusChem (Weinheim, Germany) Germany), 2024-09, Vol.89 (9), p.e202400243-n/a
Hauptverfasser:	Palmioli, Alessandro, Airoldi, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Alzheimer's disease Amyloid - antagonists & inhibitors Amyloid - chemistry Amyloid - metabolism amyloid aggregates amyloid inhibitors Binding Humans Ligands molecular recognition neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular Oligomers Parkinson's disease Peptides Protein Binding Proteins Structural analysis Toolkits Topology Toxic diseases
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