Electrochemical benzylic deuteration of p -QMs enabling the synthesis of benzylic deuterated diarylmethanes

Electrochemical benzylic deuteration of p -QMs enabling the synthesis of benzylic deuterated diarylmethanes

Herein, electroreductive umpolung benzylic deuteration of -QMs using cheap and easily accessible D O as a deuterium source is reported. Various value-added benzylic deuterated diarylmethanes can be synthesized without the requirement of noble metal catalysts, redox reagents, and strong bases. The es...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-05, Vol.22 (20), p.4047-4051
Hauptverfasser: Yan, Yunying, Hao, Jianjun, Peng, Yulin, Yin, Mengyun, Jing, Linhai, Han, Pan
Format: Artikel
Sprache:eng
Schlagworte:
Catalysts
Deuteration
Deuterium
Electrochemistry
Noble metals
Reagents
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Zusammenfassung:Herein, electroreductive umpolung benzylic deuteration of -QMs using cheap and easily accessible D O as a deuterium source is reported. Various value-added benzylic deuterated diarylmethanes can be synthesized without the requirement of noble metal catalysts, redox reagents, and strong bases. The establishment of this protocol will provide an alternative strategy for acquiring benzylic deuterated diarylmethanes.
ISSN:1477-0520
1477-0539
DOI:10.1039/d4ob00537f