Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex

Using copper-ionophores to translocate extracellular copper into mitochondria is a clinically validated anticancer strategy that has been identified as a new type of regulated cell death termed “cuproptosis.” This study reports a mitochondria-targeting Cu­(I) complex, Cu­(I)­Br­(PPh3)3 (CBP), consis...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-05, Vol.67 (10), p.7911-7920
Hauptverfasser:	Xu, Siyu, Hao, Yashuai, Xu, Xinyi, Huang, Lu, Liang, Yuqiong, Liao, Jia, Yang, Jie-Ru, Zhou, Yang, Huang, Mingdong, Du, Ke-Zhao, Zhang, Cen, Xu, Peng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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