Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling

Introduction Natriuretic peptide receptor-A (NPR-A) signaling system is considered as an intrinsic productive mechanism of the heart that opposes abnormal cardiac remodeling and hypertrophic growth. NPR-A is coded by Npr1 gene, and its expression is downregulated in the hypertrophied heart. Aim We s...

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Veröffentlicht in:	Endocrine 2024-09, Vol.85 (3), p.1075-1090
Hauptverfasser:	Nagaraj, Gopinath, Vellaichamy, Elangovan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Adrenergic receptors Animals Antioxidants Brief Report Cardiomyocytes Cell Line Cell size Curcumin Cyclic GMP Cyclic GMP - metabolism Diabetes Down-regulation Down-Regulation - drug effects Endocrinology Enzyme-linked immunosorbent assay Gene regulation Humanities and Social Sciences Hypertrophy Immunofluorescence Internal Medicine Intracellular Kinases Major histocompatibility complex Medicine Medicine & Public Health multidisciplinary Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NPR1 gene Peptides Protein folding Protein kinase C Rats Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Atrial Natriuretic Factor - genetics Receptors, Atrial Natriuretic Factor - metabolism Science Signal Transduction - drug effects Transcription Transcription, Genetic - drug effects Triiodothyronine - pharmacology
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