Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative
Background Multicenter early diuretic response (DR) analysis of single furosemide dosing following neonatal cardiac surgery is lacking to inform whether early DR predicts adverse clinical outcomes. Methods We performed a retrospective cohort study utilizing data from the NEPHRON registry. Random for...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2024-09, Vol.39 (9), p.2797-2805 |
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| creator | Blinder, Joshua J. Alten, Jeffrey Bailly, David Buckley, Jason Clarke, Shanelle Diddle, J. Wesley Garcia, Xiomara Gist, Katja M. Koch, Joshua Kwiatkowski, David M. Rahman, A. K. M. Fazlur Reichle, Garrett Valentine, Kevin Hock, Kristal M. Borasino, Santiago |
| description | Background
Multicenter early diuretic response (DR) analysis of single furosemide dosing following neonatal cardiac surgery is lacking to inform whether early DR predicts adverse clinical outcomes.
Methods
We performed a retrospective cohort study utilizing data from the NEPHRON registry. Random forest machine learning generated receiver operating characteristic-area under the curve (ROC-AUC) and odds ratios for mechanical ventilation (MV) and respiratory support (RS). Prolonged MV and RS were defined using ≥ 90th percentile of observed/expected ratios. Secondary outcomes were prolonged CICU and hospital length of stay (LOS) and kidney failure (stage III acute kidney injury (AKI), peritoneal dialysis, and/or continuous kidney replacement therapy on postoperative day three) assessed using covariate-adjusted ROC-AUC curves.
Results
A total of 782 children were included. Cumulative urine output (UOP) metrics were lower in prolonged MV and RS patients, but DR poorly predicted prolonged MV (highest AUC 0.611, OR 0.98, sensitivity 0.67, specificity 0.53,
p
= 0.006, 95% OR CI 0.96–0.99 for cumulative 6-h UOP) and RS (highest AUC 0.674, OR 0.94, sensitivity 0.75, specificity 0.54,
p
|
| doi_str_mv | 10.1007/s00467-024-06380-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3051939298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3051939298</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-8af20870d90d4abab6d4a046134b14c19d48dca6fb69b73541daa83030173e543</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwBxiQJRaWwPkjicOGSqFIVYsQSGWyHMeBVG1c7AQp_x5DC0gMTDfcc-_dPQgdEzgnAOmFB-BJGgHlESRMQNTtoD7hjEYkE_Nd1IeMkQg4mffQgfcLABCxSPZRj4mUMEpFHz1fV60zTaWxM35ta2-wKhvjcG1srRq1xFq5olIa-9a9GNddYhXQtXUNLp1d4ebV4Onofvwwm2Jtl0uVW6ea6t0cor1SLb052tYBeroZPQ7H0WR2eze8mkSapXETCVVSECkUGRRc5SpPQgl_EcZzwjXJCi4KrZIyT7I8ZTEnhVKCAQOSMhNzNkBnm9y1s2-t8Y1cVV6bcEl4ofWSQUwyltFMBPT0D7qwravDdYESPE4pjeNA0Q2lnfXemVKuXbVSrpME5Kd4uREvg3j5JV52YehkG93mK1P8jHybDgDbAD606mDyd_c_sR9F9o34</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3084572255</pqid></control><display><type>article</type><title>Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Blinder, Joshua J. ; Alten, Jeffrey ; Bailly, David ; Buckley, Jason ; Clarke, Shanelle ; Diddle, J. Wesley ; Garcia, Xiomara ; Gist, Katja M. ; Koch, Joshua ; Kwiatkowski, David M. ; Rahman, A. K. M. Fazlur ; Reichle, Garrett ; Valentine, Kevin ; Hock, Kristal M. ; Borasino, Santiago</creator><creatorcontrib>Blinder, Joshua J. ; Alten, Jeffrey ; Bailly, David ; Buckley, Jason ; Clarke, Shanelle ; Diddle, J. Wesley ; Garcia, Xiomara ; Gist, Katja M. ; Koch, Joshua ; Kwiatkowski, David M. ; Rahman, A. K. M. Fazlur ; Reichle, Garrett ; Valentine, Kevin ; Hock, Kristal M. ; Borasino, Santiago ; NEPHRON Collaborators</creatorcontrib><description>Background
Multicenter early diuretic response (DR) analysis of single furosemide dosing following neonatal cardiac surgery is lacking to inform whether early DR predicts adverse clinical outcomes.
Methods
We performed a retrospective cohort study utilizing data from the NEPHRON registry. Random forest machine learning generated receiver operating characteristic-area under the curve (ROC-AUC) and odds ratios for mechanical ventilation (MV) and respiratory support (RS). Prolonged MV and RS were defined using ≥ 90th percentile of observed/expected ratios. Secondary outcomes were prolonged CICU and hospital length of stay (LOS) and kidney failure (stage III acute kidney injury (AKI), peritoneal dialysis, and/or continuous kidney replacement therapy on postoperative day three) assessed using covariate-adjusted ROC-AUC curves.
Results
A total of 782 children were included. Cumulative urine output (UOP) metrics were lower in prolonged MV and RS patients, but DR poorly predicted prolonged MV (highest AUC 0.611, OR 0.98, sensitivity 0.67, specificity 0.53,
p
= 0.006, 95% OR CI 0.96–0.99 for cumulative 6-h UOP) and RS (highest AUC 0.674, OR 0.94, sensitivity 0.75, specificity 0.54,
p
< 0.001, 95% CI 0.91–0.97 UOP between 3 and 6 h). Secondary outcome results were similar. DR had fair discrimination for kidney failure (AUC 0.703, OR 0.94, sensitivity 0.63, specificity 0.71, 95% OR CI 0.91–0.98,
p
< 0.001, cumulative 6-h UOP).
Conclusions
Early DR poorly discriminated patients with prolonged MV, RS, and LOS in this cohort, though it may identify severe postoperative AKI phenotype. Future work is warranted to determine if early DR or late postoperative DR later, in combination with other AKI metrics, may identify a higher-risk phenotype.
Graphical abstract
A higher resolution version of the Graphical abstract is available as
Supplementary information</description><identifier>ISSN: 0931-041X</identifier><identifier>ISSN: 1432-198X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-024-06380-y</identifier><identifier>PMID: 38713228</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject><![CDATA[Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Cardiac Surgical Procedures - adverse effects ; Diuretics ; Diuretics - administration & dosage ; Diuretics - therapeutic use ; Female ; Furosemide ; Furosemide - administration & dosage ; Heart ; Heart surgery ; Humans ; Infant ; Infant, Newborn ; Kidney diseases ; Length of Stay - statistics & numerical data ; Male ; Mechanical ventilation ; Medicine ; Medicine & Public Health ; Neonates ; Nephrology ; Original Article ; Patients ; Pediatrics ; Peritoneal dialysis ; Phenotypes ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Postoperative Complications - prevention & control ; Registries - statistics & numerical data ; Renal failure ; Respiration, Artificial - statistics & numerical data ; Retrospective Studies ; ROC Curve ; Treatment Outcome ; Urology]]></subject><ispartof>Pediatric nephrology (Berlin, West), 2024-09, Vol.39 (9), p.2797-2805</ispartof><rights>The Author(s), under exclusive licence to International Pediatric Nephrology Association 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8af20870d90d4abab6d4a046134b14c19d48dca6fb69b73541daa83030173e543</citedby><cites>FETCH-LOGICAL-c375t-8af20870d90d4abab6d4a046134b14c19d48dca6fb69b73541daa83030173e543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-024-06380-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-024-06380-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38713228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blinder, Joshua J.</creatorcontrib><creatorcontrib>Alten, Jeffrey</creatorcontrib><creatorcontrib>Bailly, David</creatorcontrib><creatorcontrib>Buckley, Jason</creatorcontrib><creatorcontrib>Clarke, Shanelle</creatorcontrib><creatorcontrib>Diddle, J. Wesley</creatorcontrib><creatorcontrib>Garcia, Xiomara</creatorcontrib><creatorcontrib>Gist, Katja M.</creatorcontrib><creatorcontrib>Koch, Joshua</creatorcontrib><creatorcontrib>Kwiatkowski, David M.</creatorcontrib><creatorcontrib>Rahman, A. K. M. Fazlur</creatorcontrib><creatorcontrib>Reichle, Garrett</creatorcontrib><creatorcontrib>Valentine, Kevin</creatorcontrib><creatorcontrib>Hock, Kristal M.</creatorcontrib><creatorcontrib>Borasino, Santiago</creatorcontrib><creatorcontrib>NEPHRON Collaborators</creatorcontrib><title>Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
Multicenter early diuretic response (DR) analysis of single furosemide dosing following neonatal cardiac surgery is lacking to inform whether early DR predicts adverse clinical outcomes.
Methods
We performed a retrospective cohort study utilizing data from the NEPHRON registry. Random forest machine learning generated receiver operating characteristic-area under the curve (ROC-AUC) and odds ratios for mechanical ventilation (MV) and respiratory support (RS). Prolonged MV and RS were defined using ≥ 90th percentile of observed/expected ratios. Secondary outcomes were prolonged CICU and hospital length of stay (LOS) and kidney failure (stage III acute kidney injury (AKI), peritoneal dialysis, and/or continuous kidney replacement therapy on postoperative day three) assessed using covariate-adjusted ROC-AUC curves.
Results
A total of 782 children were included. Cumulative urine output (UOP) metrics were lower in prolonged MV and RS patients, but DR poorly predicted prolonged MV (highest AUC 0.611, OR 0.98, sensitivity 0.67, specificity 0.53,
p
= 0.006, 95% OR CI 0.96–0.99 for cumulative 6-h UOP) and RS (highest AUC 0.674, OR 0.94, sensitivity 0.75, specificity 0.54,
p
< 0.001, 95% CI 0.91–0.97 UOP between 3 and 6 h). Secondary outcome results were similar. DR had fair discrimination for kidney failure (AUC 0.703, OR 0.94, sensitivity 0.63, specificity 0.71, 95% OR CI 0.91–0.98,
p
< 0.001, cumulative 6-h UOP).
Conclusions
Early DR poorly discriminated patients with prolonged MV, RS, and LOS in this cohort, though it may identify severe postoperative AKI phenotype. Future work is warranted to determine if early DR or late postoperative DR later, in combination with other AKI metrics, may identify a higher-risk phenotype.
Graphical abstract
A higher resolution version of the Graphical abstract is available as
Supplementary information</description><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Diuretics</subject><subject>Diuretics - administration & dosage</subject><subject>Diuretics - therapeutic use</subject><subject>Female</subject><subject>Furosemide</subject><subject>Furosemide - administration & dosage</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kidney diseases</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Peritoneal dialysis</subject><subject>Phenotypes</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Registries - statistics & numerical data</subject><subject>Renal failure</subject><subject>Respiration, Artificial - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Treatment Outcome</subject><subject>Urology</subject><issn>0931-041X</issn><issn>1432-198X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxiQJRaWwPkjicOGSqFIVYsQSGWyHMeBVG1c7AQp_x5DC0gMTDfcc-_dPQgdEzgnAOmFB-BJGgHlESRMQNTtoD7hjEYkE_Nd1IeMkQg4mffQgfcLABCxSPZRj4mUMEpFHz1fV60zTaWxM35ta2-wKhvjcG1srRq1xFq5olIa-9a9GNddYhXQtXUNLp1d4ebV4Onofvwwm2Jtl0uVW6ea6t0cor1SLb052tYBeroZPQ7H0WR2eze8mkSapXETCVVSECkUGRRc5SpPQgl_EcZzwjXJCi4KrZIyT7I8ZTEnhVKCAQOSMhNzNkBnm9y1s2-t8Y1cVV6bcEl4ofWSQUwyltFMBPT0D7qwravDdYESPE4pjeNA0Q2lnfXemVKuXbVSrpME5Kd4uREvg3j5JV52YehkG93mK1P8jHybDgDbAD606mDyd_c_sR9F9o34</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Blinder, Joshua J.</creator><creator>Alten, Jeffrey</creator><creator>Bailly, David</creator><creator>Buckley, Jason</creator><creator>Clarke, Shanelle</creator><creator>Diddle, J. Wesley</creator><creator>Garcia, Xiomara</creator><creator>Gist, Katja M.</creator><creator>Koch, Joshua</creator><creator>Kwiatkowski, David M.</creator><creator>Rahman, A. K. M. Fazlur</creator><creator>Reichle, Garrett</creator><creator>Valentine, Kevin</creator><creator>Hock, Kristal M.</creator><creator>Borasino, Santiago</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20240901</creationdate><title>Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative</title><author>Blinder, Joshua J. ; Alten, Jeffrey ; Bailly, David ; Buckley, Jason ; Clarke, Shanelle ; Diddle, J. Wesley ; Garcia, Xiomara ; Gist, Katja M. ; Koch, Joshua ; Kwiatkowski, David M. ; Rahman, A. K. M. Fazlur ; Reichle, Garrett ; Valentine, Kevin ; Hock, Kristal M. ; Borasino, Santiago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8af20870d90d4abab6d4a046134b14c19d48dca6fb69b73541daa83030173e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Diuretics</topic><topic>Diuretics - administration & dosage</topic><topic>Diuretics - therapeutic use</topic><topic>Female</topic><topic>Furosemide</topic><topic>Furosemide - administration & dosage</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Kidney diseases</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Peritoneal dialysis</topic><topic>Phenotypes</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Registries - statistics & numerical data</topic><topic>Renal failure</topic><topic>Respiration, Artificial - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Treatment Outcome</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blinder, Joshua J.</creatorcontrib><creatorcontrib>Alten, Jeffrey</creatorcontrib><creatorcontrib>Bailly, David</creatorcontrib><creatorcontrib>Buckley, Jason</creatorcontrib><creatorcontrib>Clarke, Shanelle</creatorcontrib><creatorcontrib>Diddle, J. Wesley</creatorcontrib><creatorcontrib>Garcia, Xiomara</creatorcontrib><creatorcontrib>Gist, Katja M.</creatorcontrib><creatorcontrib>Koch, Joshua</creatorcontrib><creatorcontrib>Kwiatkowski, David M.</creatorcontrib><creatorcontrib>Rahman, A. K. M. Fazlur</creatorcontrib><creatorcontrib>Reichle, Garrett</creatorcontrib><creatorcontrib>Valentine, Kevin</creatorcontrib><creatorcontrib>Hock, Kristal M.</creatorcontrib><creatorcontrib>Borasino, Santiago</creatorcontrib><creatorcontrib>NEPHRON Collaborators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blinder, Joshua J.</au><au>Alten, Jeffrey</au><au>Bailly, David</au><au>Buckley, Jason</au><au>Clarke, Shanelle</au><au>Diddle, J. Wesley</au><au>Garcia, Xiomara</au><au>Gist, Katja M.</au><au>Koch, Joshua</au><au>Kwiatkowski, David M.</au><au>Rahman, A. K. M. Fazlur</au><au>Reichle, Garrett</au><au>Valentine, Kevin</au><au>Hock, Kristal M.</au><au>Borasino, Santiago</au><aucorp>NEPHRON Collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>39</volume><issue>9</issue><spage>2797</spage><epage>2805</epage><pages>2797-2805</pages><issn>0931-041X</issn><issn>1432-198X</issn><eissn>1432-198X</eissn><abstract>Background
Multicenter early diuretic response (DR) analysis of single furosemide dosing following neonatal cardiac surgery is lacking to inform whether early DR predicts adverse clinical outcomes.
Methods
We performed a retrospective cohort study utilizing data from the NEPHRON registry. Random forest machine learning generated receiver operating characteristic-area under the curve (ROC-AUC) and odds ratios for mechanical ventilation (MV) and respiratory support (RS). Prolonged MV and RS were defined using ≥ 90th percentile of observed/expected ratios. Secondary outcomes were prolonged CICU and hospital length of stay (LOS) and kidney failure (stage III acute kidney injury (AKI), peritoneal dialysis, and/or continuous kidney replacement therapy on postoperative day three) assessed using covariate-adjusted ROC-AUC curves.
Results
A total of 782 children were included. Cumulative urine output (UOP) metrics were lower in prolonged MV and RS patients, but DR poorly predicted prolonged MV (highest AUC 0.611, OR 0.98, sensitivity 0.67, specificity 0.53,
p
= 0.006, 95% OR CI 0.96–0.99 for cumulative 6-h UOP) and RS (highest AUC 0.674, OR 0.94, sensitivity 0.75, specificity 0.54,
p
< 0.001, 95% CI 0.91–0.97 UOP between 3 and 6 h). Secondary outcome results were similar. DR had fair discrimination for kidney failure (AUC 0.703, OR 0.94, sensitivity 0.63, specificity 0.71, 95% OR CI 0.91–0.98,
p
< 0.001, cumulative 6-h UOP).
Conclusions
Early DR poorly discriminated patients with prolonged MV, RS, and LOS in this cohort, though it may identify severe postoperative AKI phenotype. Future work is warranted to determine if early DR or late postoperative DR later, in combination with other AKI metrics, may identify a higher-risk phenotype.
Graphical abstract
A higher resolution version of the Graphical abstract is available as
Supplementary information</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38713228</pmid><doi>10.1007/s00467-024-06380-y</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2024-09, Vol.39 (9), p.2797-2805 |
| issn | 0931-041X 1432-198X 1432-198X |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Cardiac Surgical Procedures - adverse effects Diuretics Diuretics - administration & dosage Diuretics - therapeutic use Female Furosemide Furosemide - administration & dosage Heart Heart surgery Humans Infant Infant, Newborn Kidney diseases Length of Stay - statistics & numerical data Male Mechanical ventilation Medicine Medicine & Public Health Neonates Nephrology Original Article Patients Pediatrics Peritoneal dialysis Phenotypes Postoperative Complications - epidemiology Postoperative Complications - etiology Postoperative Complications - prevention & control Registries - statistics & numerical data Renal failure Respiration, Artificial - statistics & numerical data Retrospective Studies ROC Curve Treatment Outcome Urology |
| title | Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative |
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