Patterns of primary and secondary defects associated with non‐syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population

Cleft lip and palate deformities substantially burden individuals and families, particularly in low‐income communities. However, a comprehensive understanding of the patterns and distribution of these deformities in Kenya remains limited. This retrospective cross‐sectional study analyzed 647 clinica...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Congenital anomalies 2024-05, Vol.64 (3), p.134-142
Hauptverfasser: Kamau, Martin, Sarna, Krishan, Guthua, Symon, Sonigra, Khushboo Jayant, Kimani, Paul
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 142
container_issue 3
container_start_page 134
container_title Congenital anomalies
container_volume 64
creator Kamau, Martin
Sarna, Krishan
Guthua, Symon
Sonigra, Khushboo Jayant
Kimani, Paul
description Cleft lip and palate deformities substantially burden individuals and families, particularly in low‐income communities. However, a comprehensive understanding of the patterns and distribution of these deformities in Kenya remains limited. This retrospective cross‐sectional study analyzed 647 clinical records from the BelaRisu Foundation registry in Kenya, spanning 2018–2022. After meticulous record verification and data extraction, cleft pattern modeling was used to analyze each case. Data were imported to SPSS version 29.0 and descriptive statistics were calculated, which included means, ranges, frequencies, percentages, and standard deviations. Additionally, a comparative analysis between genders was conducted. The findings revealed a higher average age of presentation compared with previous studies in Kenya, along with a greater susceptibility of males to cleft lip and palate defects overall. Noteworthy disparities in case distribution across provinces were observed. Cleft lip emerged as the most observed primary defect, while palatal fistulae constituted the most frequent secondary defect. Interestingly, while some results aligned with global trends, others diverged significantly from the existing literature, warranting further exploration and investigation. These findings shed light on the unique patterns and distribution of cleft lip and palate deformities in Kenya, highlighting the need for targeted interventions and support systems.
doi_str_mv 10.1111/cga.12564
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3051426074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3051426074</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2434-bbd5d9ab190580c44b29c9b0c16c598296263e8b6b64a36ba5befc59c0b2e38a3</originalsourceid><addsrcrecordid>eNp10c1qFTEYBuAgij1WF96ABNzUxbT5PzPuDget0oIudD3k55uakknGyQxldl6CeIm9EnN-2oVgNiF8T15IXoReU3JOy7qwN_qcMqnEE7Sia0ErIRl5ilakoaLiksgT9CLnW0KYUmvyHJ3wWnJChVqhP1_1NMEYM04dHkbf63HBOjqcwabodicHHdgpY51zsl5P4PCdn37gmOL9r995iW5MvbfYBugmHPywvz_oUOh7vIkYBu-g9ymkG291KGMdluwz9hFrfAVx0REPaZjLDZ_iS_Ss0yHDq-N-ir5__PBt-6m6_nL5ebu5riwTXFTGOOkabWhDZE2sEIY1tjHEUmVlU7NGMcWhNsooobkyWhroysQSw4DXmp-is0PuMKafM-Sp7X22EIKOkObcciKpYIqsRaFv_6G3aR7LM_aqCMXpTr07KDumnEfo2uOHtpS0u6LaUlS7L6rYN8fE2fTgHuVDMwVcHMCdD7D8P6ndXm4OkX8By4qfZg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3050746314</pqid></control><display><type>article</type><title>Patterns of primary and secondary defects associated with non‐syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population</title><source>Access via Wiley Online Library</source><creator>Kamau, Martin ; Sarna, Krishan ; Guthua, Symon ; Sonigra, Khushboo Jayant ; Kimani, Paul</creator><creatorcontrib>Kamau, Martin ; Sarna, Krishan ; Guthua, Symon ; Sonigra, Khushboo Jayant ; Kimani, Paul</creatorcontrib><description>Cleft lip and palate deformities substantially burden individuals and families, particularly in low‐income communities. However, a comprehensive understanding of the patterns and distribution of these deformities in Kenya remains limited. This retrospective cross‐sectional study analyzed 647 clinical records from the BelaRisu Foundation registry in Kenya, spanning 2018–2022. After meticulous record verification and data extraction, cleft pattern modeling was used to analyze each case. Data were imported to SPSS version 29.0 and descriptive statistics were calculated, which included means, ranges, frequencies, percentages, and standard deviations. Additionally, a comparative analysis between genders was conducted. The findings revealed a higher average age of presentation compared with previous studies in Kenya, along with a greater susceptibility of males to cleft lip and palate defects overall. Noteworthy disparities in case distribution across provinces were observed. Cleft lip emerged as the most observed primary defect, while palatal fistulae constituted the most frequent secondary defect. Interestingly, while some results aligned with global trends, others diverged significantly from the existing literature, warranting further exploration and investigation. These findings shed light on the unique patterns and distribution of cleft lip and palate deformities in Kenya, highlighting the need for targeted interventions and support systems.</description><identifier>ISSN: 0914-3505</identifier><identifier>EISSN: 1741-4520</identifier><identifier>DOI: 10.1111/cga.12564</identifier><identifier>PMID: 38530146</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>cleft lip ; Cleft lip/palate ; cleft palate ; Comparative analysis ; Defects ; Epidemiology ; Fistulae ; patterns ; secondary defects ; Statistical analysis ; Support systems</subject><ispartof>Congenital anomalies, 2024-05, Vol.64 (3), p.134-142</ispartof><rights>2024 Japanese Teratology Society.</rights><rights>2024 Japanese Teratology Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2434-bbd5d9ab190580c44b29c9b0c16c598296263e8b6b64a36ba5befc59c0b2e38a3</cites><orcidid>0000-0003-4369-093X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcga.12564$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcga.12564$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38530146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamau, Martin</creatorcontrib><creatorcontrib>Sarna, Krishan</creatorcontrib><creatorcontrib>Guthua, Symon</creatorcontrib><creatorcontrib>Sonigra, Khushboo Jayant</creatorcontrib><creatorcontrib>Kimani, Paul</creatorcontrib><title>Patterns of primary and secondary defects associated with non‐syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population</title><title>Congenital anomalies</title><addtitle>Congenit Anom (Kyoto)</addtitle><description>Cleft lip and palate deformities substantially burden individuals and families, particularly in low‐income communities. However, a comprehensive understanding of the patterns and distribution of these deformities in Kenya remains limited. This retrospective cross‐sectional study analyzed 647 clinical records from the BelaRisu Foundation registry in Kenya, spanning 2018–2022. After meticulous record verification and data extraction, cleft pattern modeling was used to analyze each case. Data were imported to SPSS version 29.0 and descriptive statistics were calculated, which included means, ranges, frequencies, percentages, and standard deviations. Additionally, a comparative analysis between genders was conducted. The findings revealed a higher average age of presentation compared with previous studies in Kenya, along with a greater susceptibility of males to cleft lip and palate defects overall. Noteworthy disparities in case distribution across provinces were observed. Cleft lip emerged as the most observed primary defect, while palatal fistulae constituted the most frequent secondary defect. Interestingly, while some results aligned with global trends, others diverged significantly from the existing literature, warranting further exploration and investigation. These findings shed light on the unique patterns and distribution of cleft lip and palate deformities in Kenya, highlighting the need for targeted interventions and support systems.</description><subject>cleft lip</subject><subject>Cleft lip/palate</subject><subject>cleft palate</subject><subject>Comparative analysis</subject><subject>Defects</subject><subject>Epidemiology</subject><subject>Fistulae</subject><subject>patterns</subject><subject>secondary defects</subject><subject>Statistical analysis</subject><subject>Support systems</subject><issn>0914-3505</issn><issn>1741-4520</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp10c1qFTEYBuAgij1WF96ABNzUxbT5PzPuDget0oIudD3k55uakknGyQxldl6CeIm9EnN-2oVgNiF8T15IXoReU3JOy7qwN_qcMqnEE7Sia0ErIRl5ilakoaLiksgT9CLnW0KYUmvyHJ3wWnJChVqhP1_1NMEYM04dHkbf63HBOjqcwabodicHHdgpY51zsl5P4PCdn37gmOL9r995iW5MvbfYBugmHPywvz_oUOh7vIkYBu-g9ymkG291KGMdluwz9hFrfAVx0REPaZjLDZ_iS_Ss0yHDq-N-ir5__PBt-6m6_nL5ebu5riwTXFTGOOkabWhDZE2sEIY1tjHEUmVlU7NGMcWhNsooobkyWhroysQSw4DXmp-is0PuMKafM-Sp7X22EIKOkObcciKpYIqsRaFv_6G3aR7LM_aqCMXpTr07KDumnEfo2uOHtpS0u6LaUlS7L6rYN8fE2fTgHuVDMwVcHMCdD7D8P6ndXm4OkX8By4qfZg</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Kamau, Martin</creator><creator>Sarna, Krishan</creator><creator>Guthua, Symon</creator><creator>Sonigra, Khushboo Jayant</creator><creator>Kimani, Paul</creator><general>John Wiley &amp; Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4369-093X</orcidid></search><sort><creationdate>202405</creationdate><title>Patterns of primary and secondary defects associated with non‐syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population</title><author>Kamau, Martin ; Sarna, Krishan ; Guthua, Symon ; Sonigra, Khushboo Jayant ; Kimani, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2434-bbd5d9ab190580c44b29c9b0c16c598296263e8b6b64a36ba5befc59c0b2e38a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>cleft lip</topic><topic>Cleft lip/palate</topic><topic>cleft palate</topic><topic>Comparative analysis</topic><topic>Defects</topic><topic>Epidemiology</topic><topic>Fistulae</topic><topic>patterns</topic><topic>secondary defects</topic><topic>Statistical analysis</topic><topic>Support systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamau, Martin</creatorcontrib><creatorcontrib>Sarna, Krishan</creatorcontrib><creatorcontrib>Guthua, Symon</creatorcontrib><creatorcontrib>Sonigra, Khushboo Jayant</creatorcontrib><creatorcontrib>Kimani, Paul</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Congenital anomalies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamau, Martin</au><au>Sarna, Krishan</au><au>Guthua, Symon</au><au>Sonigra, Khushboo Jayant</au><au>Kimani, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of primary and secondary defects associated with non‐syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population</atitle><jtitle>Congenital anomalies</jtitle><addtitle>Congenit Anom (Kyoto)</addtitle><date>2024-05</date><risdate>2024</risdate><volume>64</volume><issue>3</issue><spage>134</spage><epage>142</epage><pages>134-142</pages><issn>0914-3505</issn><eissn>1741-4520</eissn><abstract>Cleft lip and palate deformities substantially burden individuals and families, particularly in low‐income communities. However, a comprehensive understanding of the patterns and distribution of these deformities in Kenya remains limited. This retrospective cross‐sectional study analyzed 647 clinical records from the BelaRisu Foundation registry in Kenya, spanning 2018–2022. After meticulous record verification and data extraction, cleft pattern modeling was used to analyze each case. Data were imported to SPSS version 29.0 and descriptive statistics were calculated, which included means, ranges, frequencies, percentages, and standard deviations. Additionally, a comparative analysis between genders was conducted. The findings revealed a higher average age of presentation compared with previous studies in Kenya, along with a greater susceptibility of males to cleft lip and palate defects overall. Noteworthy disparities in case distribution across provinces were observed. Cleft lip emerged as the most observed primary defect, while palatal fistulae constituted the most frequent secondary defect. Interestingly, while some results aligned with global trends, others diverged significantly from the existing literature, warranting further exploration and investigation. These findings shed light on the unique patterns and distribution of cleft lip and palate deformities in Kenya, highlighting the need for targeted interventions and support systems.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley &amp; Sons Australia, Ltd</pub><pmid>38530146</pmid><doi>10.1111/cga.12564</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4369-093X</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0914-3505
ispartof Congenital anomalies, 2024-05, Vol.64 (3), p.134-142
issn 0914-3505
1741-4520
language eng
recordid cdi_proquest_miscellaneous_3051426074
source Access via Wiley Online Library
subjects cleft lip
Cleft lip/palate
cleft palate
Comparative analysis
Defects
Epidemiology
Fistulae
patterns
secondary defects
Statistical analysis
Support systems
title Patterns of primary and secondary defects associated with non‐syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T21%3A59%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Patterns%20of%20primary%20and%20secondary%20defects%20associated%20with%20non%E2%80%90syndromic%20cleft%20lip%20and%20palate:%20An%20epidemiological%20analysis%20in%20a%20Kenyan%20population&rft.jtitle=Congenital%20anomalies&rft.au=Kamau,%20Martin&rft.date=2024-05&rft.volume=64&rft.issue=3&rft.spage=134&rft.epage=142&rft.pages=134-142&rft.issn=0914-3505&rft.eissn=1741-4520&rft_id=info:doi/10.1111/cga.12564&rft_dat=%3Cproquest_cross%3E3051426074%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3050746314&rft_id=info:pmid/38530146&rfr_iscdi=true