Intranasal Administration of Umbilical Cord Mesenchymal Stem Cell Exosomes Alleviates Parkinson's Disease

•Intranasal administration of hUCMSC-Exos can cross the blood–brain barrier and be endocytosed by the cells.•Both motor and non-motor function of the PD model mice were effectively improved by intranasal hUCMSC-Exos treatment.•hUCMSC-Exos have neuroprotection and glia activated remission, which can...

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Veröffentlicht in:	Neuroscience 2024-06, Vol.549, p.1-12
Hauptverfasser:	Huang, Weixiao, Zhang, Tao, Li, Xiaodi, Gong, Leilei, Zhang, Yu, Luan, Chengcheng, Shan, Qi, Gu, Xiaosong, Zhao, Lili
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Disease Models, Animal dopaminergic neurons Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology exosomes Exosomes - metabolism Exosomes - transplantation Humans inflammation Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - metabolism Mice Mice, Inbred C57BL Microglia - metabolism Olfactory Bulb Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - therapy Parkinson's disease Umbilical Cord - cytology
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