Metformin improves d-galactose induced premature ovarian insufficiency through PI3K-Akt-FOXO3a pathway

Metformin (MET), a first-line treatment for type 2 diabetes mellitus, restores ovarian function in women with polycystic ovary syndrome. MET has been shown to increase the rate of success for in vitro fertilization when utilized in assisted reproductive technologies. This study was designed to exami...

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Veröffentlicht in:	Advances in medical sciences 2024-03, Vol.69 (1), p.70-80
Hauptverfasser:	Ellibishy, Fatima, Tarek, Maha, Abd-Elsalam, Marwa M., Elgayar, Nesreen, El bakly, Wesam
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycation end products Animals Apoptosis - drug effects d-galactose Disease Models, Animal Female Forkhead Box Protein O3 - metabolism Galactose Metformin Metformin - pharmacology Mice Phosphatidylinositol 3-Kinases - metabolism PI3K-Akt pathway Premature ovarian insufficiency Primary Ovarian Insufficiency - chemically induced Primary Ovarian Insufficiency - drug therapy Primary Ovarian Insufficiency - metabolism Primary Ovarian Insufficiency - pathology Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects
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