Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study
Background Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are both associated with left ventricular (LV) and left atrial (LA) structural and functional abnormalities; however, the relationship between the left atrium and ventricle in this population is unclear. Purpose To identify difference...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2025-01, Vol.61 (1), p.321-334 |
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| creator | Li, Xue‐Ming Shi, Rui Shen, Meng‐Ting Yan, Wei‐Feng Jiang, Li Min, Chen‐Yan Liu, Xiao‐Jing Guo, Ying‐Kun Yang, Zhi‐Gang |
| description | Background
Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are both associated with left ventricular (LV) and left atrial (LA) structural and functional abnormalities; however, the relationship between the left atrium and ventricle in this population is unclear.
Purpose
To identify differences between hypertensive patients with and without T2DM as the basis for further investigation the atrioventricular coupling relationship.
Study Type
Cross‐sectional, retrospective study.
Population
89 hypertensive patients without T2DM [HTN (T2DM−)] (age: 58.4 +/− 11.9 years, 48 male), 62 hypertensive patients with T2DM [HTN (T2DM+)] (age: 58.5 +/− 9.1 years, 32 male) and 70 matched controls (age: 55.0 +/− 9.6 years, 37 male).
Field Strength/Sequence
2D balanced steady‐state free precession cine sequence at 3.0 T.
Assessment
LA reservoir, conduit, and booster strain (εs, εe, and εa) and strain rate (SRs, SRe, and SRa), LV radial, circumferential and longitudinal peak strain (PS) and peak systolic strain rate and peak diastolic strain rate (PSSR and PDSR) were derived from LA and LV cine images and compared between groups.
Statistical Tests
Chi‐square or Fisher's exact test, one‐way analysis of variance, analysis of covariance, Pearson's correlation, multivariable linear regression analysis, and intraclass correlation coefficient. A P value |
| doi_str_mv | 10.1002/jmri.29427 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3050942646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3144208621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4117-e38b475f9d6acfc8f70f8b187156bb313c7fd8741c2577c38c42373b4b278f6f3</originalsourceid><addsrcrecordid>eNp9kc1uEzEUhS0EoqWw4QGQJTYIaYp_xw67KG1pUCoQhLXl8djgMDMe_EOVJ-I1cUgBiQWre6_03XPtcwB4itE5Roi82o3Rn5MFI-IeOMWckIZw2d6vPeK0wRKJE_AopR1CaLFg_CE4oVIgiik_BT_W46xNhsHB7X62kMALrzubbYI3dhh8LgmGCW6sy3CZow_f7VSLKYOOcBXKPPjpM9RT_xfRA7ywLsRRZ19X_QTf166uJXjr8xd4mVIdDth1vRiznVLlXsPlBG8-rOGV1blEC7dRm68H8Y-59PvH4IHTQ7JP7uoZ-HR1uV1dN5t3b9ar5aYxDGPRWCo7Jrhb9K02zkgnkJMdlgLztuvql41wvRQMG8KFMFQaRqigHeuIkK519Ay8OOrOMXwrNmU1-mSqE3qyoSRFEUfV6Za1FX3-D7oLJU71dYpixgiSLcGVenmkTAwpRevUHP2o415hpA7xqUN86ld8FX52J1m60fZ_0N95VQAfgVs_2P1_pNTb6uVR9CfaN6Y4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3144208621</pqid></control><display><type>article</type><title>Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Li, Xue‐Ming ; Shi, Rui ; Shen, Meng‐Ting ; Yan, Wei‐Feng ; Jiang, Li ; Min, Chen‐Yan ; Liu, Xiao‐Jing ; Guo, Ying‐Kun ; Yang, Zhi‐Gang</creator><creatorcontrib>Li, Xue‐Ming ; Shi, Rui ; Shen, Meng‐Ting ; Yan, Wei‐Feng ; Jiang, Li ; Min, Chen‐Yan ; Liu, Xiao‐Jing ; Guo, Ying‐Kun ; Yang, Zhi‐Gang</creatorcontrib><description>Background
Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are both associated with left ventricular (LV) and left atrial (LA) structural and functional abnormalities; however, the relationship between the left atrium and ventricle in this population is unclear.
Purpose
To identify differences between hypertensive patients with and without T2DM as the basis for further investigation the atrioventricular coupling relationship.
Study Type
Cross‐sectional, retrospective study.
Population
89 hypertensive patients without T2DM [HTN (T2DM−)] (age: 58.4 +/− 11.9 years, 48 male), 62 hypertensive patients with T2DM [HTN (T2DM+)] (age: 58.5 +/− 9.1 years, 32 male) and 70 matched controls (age: 55.0 +/− 9.6 years, 37 male).
Field Strength/Sequence
2D balanced steady‐state free precession cine sequence at 3.0 T.
Assessment
LA reservoir, conduit, and booster strain (εs, εe, and εa) and strain rate (SRs, SRe, and SRa), LV radial, circumferential and longitudinal peak strain (PS) and peak systolic strain rate and peak diastolic strain rate (PSSR and PDSR) were derived from LA and LV cine images and compared between groups.
Statistical Tests
Chi‐square or Fisher's exact test, one‐way analysis of variance, analysis of covariance, Pearson's correlation, multivariable linear regression analysis, and intraclass correlation coefficient. A P value <0.05 was considered significant.
Results
Compared with controls, εs, εe, SRe and PS‐longitudinal, PDSR‐radial, and PDSR‐longitudinal were significantly lower in HTN (T2DM−) group, and they were even lower in HTN (T2DM+) group than in both controls and HTN (T2DM−) group. SRs, εa, SRa, as well as PS‐radial, PS‐circumferential, PSSR‐radial, and PSSR‐circumferential were significantly lower in HTN (T2DM+) compared with controls. Multivariable regression analyses demonstrated that: T2DM and PS‐circumferential and PS‐longitudinal (β = −4.026, −0.486, and −0.670, respectively) were significantly associated with εs; T2DM and PDSR‐radial and PDSR‐circumferential were significantly associated with εe (β = −3.406, −3.352, and −6.290, respectively); T2DM and PDSR‐radial were significantly associated with SRe (β = 0.371 and 0.270, respectively); T2DM and PDSR‐longitudinal were significantly associated with εa (β = −1.831 and 5.215, respectively); and PDSR‐longitudinal was significantly associated with SRa (β = 1.07).
Data Conclusion
In hypertensive patients, there was severer LA dysfunction in those with coexisting T2DM, which may be associated with more severe LV dysfunction and suggests adverse atrioventricular coupling.
Evidence Level
3.
Technical Efficacy
Stage 3.</description><identifier>ISSN: 1053-1807</identifier><identifier>ISSN: 1522-2586</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.29427</identifier><identifier>PMID: 38703135</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Abnormalities ; Adult ; Aged ; Atria ; Circumferences ; Correlation coefficient ; Correlation coefficients ; Coupling ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnostic imaging ; Diabetes Mellitus, Type 2 - physiopathology ; Essential Hypertension - complications ; Essential Hypertension - diagnostic imaging ; Essential Hypertension - physiopathology ; Female ; Field strength ; Heart ; Heart Atria - diagnostic imaging ; Heart Atria - physiopathology ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - diagnostic imaging ; Hypertension - physiopathology ; left atrium ; left ventricle ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging, Cine - methods ; Male ; Males ; Middle Aged ; Multivariable control ; Population studies ; Regression analysis ; Retrospective Studies ; Statistical analysis ; Statistical tests ; strain ; Strain rate ; Structure-function relationships ; type 2 diabetes mellitus ; Variance analysis ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Journal of magnetic resonance imaging, 2025-01, Vol.61 (1), p.321-334</ispartof><rights>2024 International Society for Magnetic Resonance in Medicine.</rights><rights>2025 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4117-e38b475f9d6acfc8f70f8b187156bb313c7fd8741c2577c38c42373b4b278f6f3</citedby><cites>FETCH-LOGICAL-c4117-e38b475f9d6acfc8f70f8b187156bb313c7fd8741c2577c38c42373b4b278f6f3</cites><orcidid>0000-0001-8437-9887 ; 0000-0001-9341-7697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.29427$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.29427$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38703135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xue‐Ming</creatorcontrib><creatorcontrib>Shi, Rui</creatorcontrib><creatorcontrib>Shen, Meng‐Ting</creatorcontrib><creatorcontrib>Yan, Wei‐Feng</creatorcontrib><creatorcontrib>Jiang, Li</creatorcontrib><creatorcontrib>Min, Chen‐Yan</creatorcontrib><creatorcontrib>Liu, Xiao‐Jing</creatorcontrib><creatorcontrib>Guo, Ying‐Kun</creatorcontrib><creatorcontrib>Yang, Zhi‐Gang</creatorcontrib><title>Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are both associated with left ventricular (LV) and left atrial (LA) structural and functional abnormalities; however, the relationship between the left atrium and ventricle in this population is unclear.
Purpose
To identify differences between hypertensive patients with and without T2DM as the basis for further investigation the atrioventricular coupling relationship.
Study Type
Cross‐sectional, retrospective study.
Population
89 hypertensive patients without T2DM [HTN (T2DM−)] (age: 58.4 +/− 11.9 years, 48 male), 62 hypertensive patients with T2DM [HTN (T2DM+)] (age: 58.5 +/− 9.1 years, 32 male) and 70 matched controls (age: 55.0 +/− 9.6 years, 37 male).
Field Strength/Sequence
2D balanced steady‐state free precession cine sequence at 3.0 T.
Assessment
LA reservoir, conduit, and booster strain (εs, εe, and εa) and strain rate (SRs, SRe, and SRa), LV radial, circumferential and longitudinal peak strain (PS) and peak systolic strain rate and peak diastolic strain rate (PSSR and PDSR) were derived from LA and LV cine images and compared between groups.
Statistical Tests
Chi‐square or Fisher's exact test, one‐way analysis of variance, analysis of covariance, Pearson's correlation, multivariable linear regression analysis, and intraclass correlation coefficient. A P value <0.05 was considered significant.
Results
Compared with controls, εs, εe, SRe and PS‐longitudinal, PDSR‐radial, and PDSR‐longitudinal were significantly lower in HTN (T2DM−) group, and they were even lower in HTN (T2DM+) group than in both controls and HTN (T2DM−) group. SRs, εa, SRa, as well as PS‐radial, PS‐circumferential, PSSR‐radial, and PSSR‐circumferential were significantly lower in HTN (T2DM+) compared with controls. Multivariable regression analyses demonstrated that: T2DM and PS‐circumferential and PS‐longitudinal (β = −4.026, −0.486, and −0.670, respectively) were significantly associated with εs; T2DM and PDSR‐radial and PDSR‐circumferential were significantly associated with εe (β = −3.406, −3.352, and −6.290, respectively); T2DM and PDSR‐radial were significantly associated with SRe (β = 0.371 and 0.270, respectively); T2DM and PDSR‐longitudinal were significantly associated with εa (β = −1.831 and 5.215, respectively); and PDSR‐longitudinal was significantly associated with SRa (β = 1.07).
Data Conclusion
In hypertensive patients, there was severer LA dysfunction in those with coexisting T2DM, which may be associated with more severe LV dysfunction and suggests adverse atrioventricular coupling.
Evidence Level
3.
Technical Efficacy
Stage 3.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Aged</subject><subject>Atria</subject><subject>Circumferences</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Coupling</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnostic imaging</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Essential Hypertension - complications</subject><subject>Essential Hypertension - diagnostic imaging</subject><subject>Essential Hypertension - physiopathology</subject><subject>Female</subject><subject>Field strength</subject><subject>Heart</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Atria - physiopathology</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - physiopathology</subject><subject>left atrium</subject><subject>left ventricle</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>Multivariable control</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>strain</subject><subject>Strain rate</subject><subject>Structure-function relationships</subject><subject>type 2 diabetes mellitus</subject><subject>Variance analysis</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1053-1807</issn><issn>1522-2586</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS0EoqWw4QGQJTYIaYp_xw67KG1pUCoQhLXl8djgMDMe_EOVJ-I1cUgBiQWre6_03XPtcwB4itE5Roi82o3Rn5MFI-IeOMWckIZw2d6vPeK0wRKJE_AopR1CaLFg_CE4oVIgiik_BT_W46xNhsHB7X62kMALrzubbYI3dhh8LgmGCW6sy3CZow_f7VSLKYOOcBXKPPjpM9RT_xfRA7ywLsRRZ19X_QTf166uJXjr8xd4mVIdDth1vRiznVLlXsPlBG8-rOGV1blEC7dRm68H8Y-59PvH4IHTQ7JP7uoZ-HR1uV1dN5t3b9ar5aYxDGPRWCo7Jrhb9K02zkgnkJMdlgLztuvql41wvRQMG8KFMFQaRqigHeuIkK519Ay8OOrOMXwrNmU1-mSqE3qyoSRFEUfV6Za1FX3-D7oLJU71dYpixgiSLcGVenmkTAwpRevUHP2o415hpA7xqUN86ld8FX52J1m60fZ_0N95VQAfgVs_2P1_pNTb6uVR9CfaN6Y4</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Li, Xue‐Ming</creator><creator>Shi, Rui</creator><creator>Shen, Meng‐Ting</creator><creator>Yan, Wei‐Feng</creator><creator>Jiang, Li</creator><creator>Min, Chen‐Yan</creator><creator>Liu, Xiao‐Jing</creator><creator>Guo, Ying‐Kun</creator><creator>Yang, Zhi‐Gang</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8437-9887</orcidid><orcidid>https://orcid.org/0000-0001-9341-7697</orcidid></search><sort><creationdate>202501</creationdate><title>Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study</title><author>Li, Xue‐Ming ; Shi, Rui ; Shen, Meng‐Ting ; Yan, Wei‐Feng ; Jiang, Li ; Min, Chen‐Yan ; Liu, Xiao‐Jing ; Guo, Ying‐Kun ; Yang, Zhi‐Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4117-e38b475f9d6acfc8f70f8b187156bb313c7fd8741c2577c38c42373b4b278f6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Abnormalities</topic><topic>Adult</topic><topic>Aged</topic><topic>Atria</topic><topic>Circumferences</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Coupling</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnostic imaging</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Essential Hypertension - complications</topic><topic>Essential Hypertension - diagnostic imaging</topic><topic>Essential Hypertension - physiopathology</topic><topic>Female</topic><topic>Field strength</topic><topic>Heart</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Heart Atria - physiopathology</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - physiopathology</topic><topic>left atrium</topic><topic>left ventricle</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging, Cine - methods</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>Multivariable control</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>strain</topic><topic>Strain rate</topic><topic>Structure-function relationships</topic><topic>type 2 diabetes mellitus</topic><topic>Variance analysis</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xue‐Ming</creatorcontrib><creatorcontrib>Shi, Rui</creatorcontrib><creatorcontrib>Shen, Meng‐Ting</creatorcontrib><creatorcontrib>Yan, Wei‐Feng</creatorcontrib><creatorcontrib>Jiang, Li</creatorcontrib><creatorcontrib>Min, Chen‐Yan</creatorcontrib><creatorcontrib>Liu, Xiao‐Jing</creatorcontrib><creatorcontrib>Guo, Ying‐Kun</creatorcontrib><creatorcontrib>Yang, Zhi‐Gang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xue‐Ming</au><au>Shi, Rui</au><au>Shen, Meng‐Ting</au><au>Yan, Wei‐Feng</au><au>Jiang, Li</au><au>Min, Chen‐Yan</au><au>Liu, Xiao‐Jing</au><au>Guo, Ying‐Kun</au><au>Yang, Zhi‐Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2025-01</date><risdate>2025</risdate><volume>61</volume><issue>1</issue><spage>321</spage><epage>334</epage><pages>321-334</pages><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>Background
Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are both associated with left ventricular (LV) and left atrial (LA) structural and functional abnormalities; however, the relationship between the left atrium and ventricle in this population is unclear.
Purpose
To identify differences between hypertensive patients with and without T2DM as the basis for further investigation the atrioventricular coupling relationship.
Study Type
Cross‐sectional, retrospective study.
Population
89 hypertensive patients without T2DM [HTN (T2DM−)] (age: 58.4 +/− 11.9 years, 48 male), 62 hypertensive patients with T2DM [HTN (T2DM+)] (age: 58.5 +/− 9.1 years, 32 male) and 70 matched controls (age: 55.0 +/− 9.6 years, 37 male).
Field Strength/Sequence
2D balanced steady‐state free precession cine sequence at 3.0 T.
Assessment
LA reservoir, conduit, and booster strain (εs, εe, and εa) and strain rate (SRs, SRe, and SRa), LV radial, circumferential and longitudinal peak strain (PS) and peak systolic strain rate and peak diastolic strain rate (PSSR and PDSR) were derived from LA and LV cine images and compared between groups.
Statistical Tests
Chi‐square or Fisher's exact test, one‐way analysis of variance, analysis of covariance, Pearson's correlation, multivariable linear regression analysis, and intraclass correlation coefficient. A P value <0.05 was considered significant.
Results
Compared with controls, εs, εe, SRe and PS‐longitudinal, PDSR‐radial, and PDSR‐longitudinal were significantly lower in HTN (T2DM−) group, and they were even lower in HTN (T2DM+) group than in both controls and HTN (T2DM−) group. SRs, εa, SRa, as well as PS‐radial, PS‐circumferential, PSSR‐radial, and PSSR‐circumferential were significantly lower in HTN (T2DM+) compared with controls. Multivariable regression analyses demonstrated that: T2DM and PS‐circumferential and PS‐longitudinal (β = −4.026, −0.486, and −0.670, respectively) were significantly associated with εs; T2DM and PDSR‐radial and PDSR‐circumferential were significantly associated with εe (β = −3.406, −3.352, and −6.290, respectively); T2DM and PDSR‐radial were significantly associated with SRe (β = 0.371 and 0.270, respectively); T2DM and PDSR‐longitudinal were significantly associated with εa (β = −1.831 and 5.215, respectively); and PDSR‐longitudinal was significantly associated with SRa (β = 1.07).
Data Conclusion
In hypertensive patients, there was severer LA dysfunction in those with coexisting T2DM, which may be associated with more severe LV dysfunction and suggests adverse atrioventricular coupling.
Evidence Level
3.
Technical Efficacy
Stage 3.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38703135</pmid><doi>10.1002/jmri.29427</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-8437-9887</orcidid><orcidid>https://orcid.org/0000-0001-9341-7697</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-1807 |
| ispartof | Journal of magnetic resonance imaging, 2025-01, Vol.61 (1), p.321-334 |
| issn | 1053-1807 1522-2586 1522-2586 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3050942646 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Abnormalities Adult Aged Atria Circumferences Correlation coefficient Correlation coefficients Coupling Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - physiopathology Essential Hypertension - complications Essential Hypertension - diagnostic imaging Essential Hypertension - physiopathology Female Field strength Heart Heart Atria - diagnostic imaging Heart Atria - physiopathology Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypertension Hypertension - complications Hypertension - diagnostic imaging Hypertension - physiopathology left atrium left ventricle Magnetic Resonance Imaging - methods Magnetic Resonance Imaging, Cine - methods Male Males Middle Aged Multivariable control Population studies Regression analysis Retrospective Studies Statistical analysis Statistical tests strain Strain rate Structure-function relationships type 2 diabetes mellitus Variance analysis Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Impact of Type 2 Diabetes Mellitus on Left Atrioventricular Coupling and Left Atrial Deformation in Patients with Essential Hypertension: An MRI Feature Tracking Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T21%3A11%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Type%202%20Diabetes%20Mellitus%20on%20Left%20Atrioventricular%20Coupling%20and%20Left%20Atrial%20Deformation%20in%20Patients%20with%20Essential%20Hypertension:%20An%20MRI%20Feature%20Tracking%20Study&rft.jtitle=Journal%20of%20magnetic%20resonance%20imaging&rft.au=Li,%20Xue%E2%80%90Ming&rft.date=2025-01&rft.volume=61&rft.issue=1&rft.spage=321&rft.epage=334&rft.pages=321-334&rft.issn=1053-1807&rft.eissn=1522-2586&rft_id=info:doi/10.1002/jmri.29427&rft_dat=%3Cproquest_cross%3E3144208621%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3144208621&rft_id=info:pmid/38703135&rfr_iscdi=true |