External validation of two clinical prediction models for mortality in COVID-19 patients (4C and NEWS2), in three centers in Medellín, Colombia: Assessing the impact of vaccination over time

•The mortality risk prediction tool 4C is more adequate, in comparison with NEWS2, as a predictor of in-hospital mortality in patients with COVID-19.•The 4C mortality risk score presented a good performance in clinically relevant metrics, with a negative likelihood ratio(LR) of 0.064 (CI 95% 0.01–0....

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