Computer-Aided Semi-Rational Design to Enhance the Activity of l‑Sorbosone Dehydrogenase from Gluconobacter oxidans WSH-004

The titer of the microbial fermentation products can be increased by enzyme engineering. l-Sorbosone dehydrogenase (SNDH) is a key enzyme in the production of 2-keto-l-gulonic acid (2-KLG), which is the precursor of vitamin C. Enhancing the activity of SNDH may have a positive impact on 2-KLG produc...

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Veröffentlicht in:Journal of agricultural and food chemistry 2024-05, Vol.72 (19), p.10995-11001
Hauptverfasser: Li, Dong, Wang, Xinglong, Huo, Lin, Zeng, Weizhu, Li, Jianghua, Zhou, Jingwen
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Sprache:eng
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