Hallmarks of cancer stemness
Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC...
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| Veröffentlicht in: | Cell stem cell 2024-05, Vol.31 (5), p.617-639 |
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| container_title | Cell stem cell |
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| creator | Loh, Jia-Jian Ma, Stephanie |
| description | Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks, along with their enabling and associated features. We also highlight potential future directions in this field of research.
Cancer stemness, regarded as a crucial factor in tumor development, has been recognized to involve a plastic cellular state influenced by dynamic interactions between cancer stem cells (CSCs) and their niche. Herein, we provide a summary of the defining and emerging hallmarks of CSCs and/or cancer stemness. |
| doi_str_mv | 10.1016/j.stem.2024.04.004 |
| format | Article |
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Cancer stemness, regarded as a crucial factor in tumor development, has been recognized to involve a plastic cellular state influenced by dynamic interactions between cancer stem cells (CSCs) and their niche. Herein, we provide a summary of the defining and emerging hallmarks of CSCs and/or cancer stemness.</description><subject>Animals</subject><subject>cancer cell plasticity</subject><subject>cancer stem cells</subject><subject>cancer stemness</subject><subject>Humans</subject><subject>immunosuppression</subject><subject>metastasis</subject><subject>Neoplasms - pathology</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>self-renewal</subject><subject>Stem Cell Niche</subject><subject>tumor microenvironment</subject><subject>tumor recurrence</subject><subject>tumor-initiating cells</subject><issn>1934-5909</issn><issn>1875-9777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLAzEQhYMotlb_gIj06GXXySbZJOBFilqh4EXPIZudwNbdbk22gv--WVo9CgMzh_cebz5CrinkFGh5v87jgF1eQMFzSAP8hEypkiLTUsrTdGvGM6FBT8hFjGsAISnIczJhSgKVQk7JzdK2bWfDZ5z3fu7sxmGYj7EbjPGSnHnbRrw67hn5eH56Xyyz1dvL6-JxlTkmyiHjBULhqK-E4B5orajTVPEaBOeqBC8qxpy0WgFgxTy4khZcMW-xdsoLymbk7pC7Df3XDuNguiY6bFu7wX4XDQMBmmmteZIWB6kLfYwBvdmGJvX_MRTMSMWszVjfjFQMpIHRdHvM31Ud1n-WXwxJ8HAQYPryu8FgomswsaibgG4wdd_8l78HtZtxEw</recordid><startdate>20240502</startdate><enddate>20240502</enddate><creator>Loh, Jia-Jian</creator><creator>Ma, Stephanie</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2029-7943</orcidid></search><sort><creationdate>20240502</creationdate><title>Hallmarks of cancer stemness</title><author>Loh, Jia-Jian ; Ma, Stephanie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-42e02c1fb554f01d81c9184d0544860f5b33c7a9800eb3f0c612483faedc8f513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>cancer cell plasticity</topic><topic>cancer stem cells</topic><topic>cancer stemness</topic><topic>Humans</topic><topic>immunosuppression</topic><topic>metastasis</topic><topic>Neoplasms - pathology</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>self-renewal</topic><topic>Stem Cell Niche</topic><topic>tumor microenvironment</topic><topic>tumor recurrence</topic><topic>tumor-initiating cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loh, Jia-Jian</creatorcontrib><creatorcontrib>Ma, Stephanie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell stem cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loh, Jia-Jian</au><au>Ma, Stephanie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hallmarks of cancer stemness</atitle><jtitle>Cell stem cell</jtitle><addtitle>Cell Stem Cell</addtitle><date>2024-05-02</date><risdate>2024</risdate><volume>31</volume><issue>5</issue><spage>617</spage><epage>639</epage><pages>617-639</pages><issn>1934-5909</issn><eissn>1875-9777</eissn><abstract>Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks, along with their enabling and associated features. We also highlight potential future directions in this field of research.
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| ispartof | Cell stem cell, 2024-05, Vol.31 (5), p.617-639 |
| issn | 1934-5909 1875-9777 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals cancer cell plasticity cancer stem cells cancer stemness Humans immunosuppression metastasis Neoplasms - pathology Neoplastic Stem Cells - pathology self-renewal Stem Cell Niche tumor microenvironment tumor recurrence tumor-initiating cells |
| title | Hallmarks of cancer stemness |
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