Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found that oligodendrocytes in the lesions are epigenetically silenced. Develo...

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Veröffentlicht in:	Cell 2024-05, Vol.187 (10), p.2465-2484.e22
Hauptverfasser:	Liu, Xuezhao, Xin, Dazhuan Eric, Zhong, Xiaowen, Zhao, Chuntao, Li, Zhidan, Zhang, Liguo, Dourson, Adam J., Lee, Lindsay, Mishra, Shreya, Bayat, Arman E., Nicholson, Eva, Seibel, William L., Yan, Bingfang, Mason, Joel, Turner, Bradley J., Gonsalvez, David G., Ong, William, Chew, Sing Yian, Ghosh, Balaram, Yoon, Sung Ok, Xin, Mei, He, Zhigang, Tchieu, Jason, Wegner, Michael, Nave, Klaus-Armin, Franklin, Robin J.M., Dutta, Ranjan, Trapp, Bruce D., Hu, Ming, Smith, Matthew A., Jankowski, Michael P., Barton, Samantha K., He, Xuelian, Lu, Q. Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	aging chromatin remodeling Epigenetic silencing HDAC3 Inhibition lipid/cholesterol biosynthesis multiple sclerosis myelin regeneration oligodendrocyte small molecule SREBP condensation
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