Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients

Introduction Megaendoprosthetic reconstruction of bone defects in skeletally immature patients has led to the development of unique complications and secondary deformities not observed in adult patient cohorts. With an increasing number of megaendoprosthetic replacements performed, orthopedic oncolo...

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Veröffentlicht in:Archives of orthopaedic and trauma surgery 2024-06, Vol.144 (6), p.2501-2510
Hauptverfasser: Guder, Wiebke K., Engel, Nina M., Streitbürger, Arne, Polan, Christina, Dudda, Marcel, Podleska, Lars E., Nottrott, Markus, Hardes, Jendrik
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container_end_page 2510
container_issue 6
container_start_page 2501
container_title Archives of orthopaedic and trauma surgery
container_volume 144
creator Guder, Wiebke K.
Engel, Nina M.
Streitbürger, Arne
Polan, Christina
Dudda, Marcel
Podleska, Lars E.
Nottrott, Markus
Hardes, Jendrik
description Introduction Megaendoprosthetic reconstruction of bone defects in skeletally immature patients has led to the development of unique complications and secondary deformities not observed in adult patient cohorts. With an increasing number of megaendoprosthetic replacements performed, orthopedic oncologists still gain experience in the incidence and type of secondary deformities caused. In this study, we report the incidence, probable cause and management outcome of two secondary deformities after megaendoprosthetic reconstruction of the proximal femur: hip dysplasia and genu valgum. Materials and methods Retrospective analysis of 14 patients who underwent primary and/or repeat reconstruction/surgery with a megaendoprosthetic proximal femur replacement between 2018 and 2022. Results Mean patient age was 9.1 years (range 4–17 years). Stress shielding was observed in 71.4%. Hip dislocation was the most frequent complication (50%). While four dislocations occurred without an underlying deformity, secondary hip dysplasia was identified in 58.3% ( n  = 7/12) of intraarticular resections and reconstructions, leading to dislocation in 71.4% ( n  = 5/7). A genu valgum deformity was observed in 41.6% ( n  = 5/12). The incidence of secondary hip dysplasia and concomitant genu valgum was 42.9% ( n  = 3/7). Triple pelvic osteotomy led to rebound hip dysplasia in two cases (patients aged 
doi_str_mv 10.1007/s00402-024-05334-1
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With an increasing number of megaendoprosthetic replacements performed, orthopedic oncologists still gain experience in the incidence and type of secondary deformities caused. In this study, we report the incidence, probable cause and management outcome of two secondary deformities after megaendoprosthetic reconstruction of the proximal femur: hip dysplasia and genu valgum. Materials and methods Retrospective analysis of 14 patients who underwent primary and/or repeat reconstruction/surgery with a megaendoprosthetic proximal femur replacement between 2018 and 2022. Results Mean patient age was 9.1 years (range 4–17 years). Stress shielding was observed in 71.4%. Hip dislocation was the most frequent complication (50%). While four dislocations occurred without an underlying deformity, secondary hip dysplasia was identified in 58.3% ( n  = 7/12) of intraarticular resections and reconstructions, leading to dislocation in 71.4% ( n  = 5/7). A genu valgum deformity was observed in 41.6% ( n  = 5/12). The incidence of secondary hip dysplasia and concomitant genu valgum was 42.9% ( n  = 3/7). Triple pelvic osteotomy led to rebound hip dysplasia in two cases (patients aged &lt; 10 years), whereas acetabular socket replacement led to stable hip joints over the course of follow-up. Temporary hemiepiphyseodesis was applied to address secondary genu valgum. Conclusions Patients aged &lt; 10 years were prone to develop secondary hip dysplasia and genu valgum following proximal femur replacement in this study. Management of secondary deformities should depend on remaining skeletal growth. Stress shielding was observed in almost all skeletally immature patients.</description><identifier>ISSN: 1434-3916</identifier><identifier>ISSN: 0936-8051</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/s00402-024-05334-1</identifier><identifier>PMID: 38700674</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bone cancer ; Hip dislocation ; Medicine ; Medicine &amp; Public Health ; Orthopaedic Surgery ; Orthopedics ; Patients ; Sarcoma</subject><ispartof>Archives of orthopaedic and trauma surgery, 2024-06, Vol.144 (6), p.2501-2510</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-8abccd35a62d009bc3d99bcd19ad04784eb05d7b5a396684a80d991260d7d323</cites><orcidid>0000-0001-9367-7130</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00402-024-05334-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00402-024-05334-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38700674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guder, Wiebke K.</creatorcontrib><creatorcontrib>Engel, Nina M.</creatorcontrib><creatorcontrib>Streitbürger, Arne</creatorcontrib><creatorcontrib>Polan, Christina</creatorcontrib><creatorcontrib>Dudda, Marcel</creatorcontrib><creatorcontrib>Podleska, Lars E.</creatorcontrib><creatorcontrib>Nottrott, Markus</creatorcontrib><creatorcontrib>Hardes, Jendrik</creatorcontrib><title>Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients</title><title>Archives of orthopaedic and trauma surgery</title><addtitle>Arch Orthop Trauma Surg</addtitle><addtitle>Arch Orthop Trauma Surg</addtitle><description>Introduction Megaendoprosthetic reconstruction of bone defects in skeletally immature patients has led to the development of unique complications and secondary deformities not observed in adult patient cohorts. With an increasing number of megaendoprosthetic replacements performed, orthopedic oncologists still gain experience in the incidence and type of secondary deformities caused. In this study, we report the incidence, probable cause and management outcome of two secondary deformities after megaendoprosthetic reconstruction of the proximal femur: hip dysplasia and genu valgum. Materials and methods Retrospective analysis of 14 patients who underwent primary and/or repeat reconstruction/surgery with a megaendoprosthetic proximal femur replacement between 2018 and 2022. Results Mean patient age was 9.1 years (range 4–17 years). Stress shielding was observed in 71.4%. Hip dislocation was the most frequent complication (50%). While four dislocations occurred without an underlying deformity, secondary hip dysplasia was identified in 58.3% ( n  = 7/12) of intraarticular resections and reconstructions, leading to dislocation in 71.4% ( n  = 5/7). A genu valgum deformity was observed in 41.6% ( n  = 5/12). The incidence of secondary hip dysplasia and concomitant genu valgum was 42.9% ( n  = 3/7). Triple pelvic osteotomy led to rebound hip dysplasia in two cases (patients aged &lt; 10 years), whereas acetabular socket replacement led to stable hip joints over the course of follow-up. Temporary hemiepiphyseodesis was applied to address secondary genu valgum. Conclusions Patients aged &lt; 10 years were prone to develop secondary hip dysplasia and genu valgum following proximal femur replacement in this study. Management of secondary deformities should depend on remaining skeletal growth. Stress shielding was observed in almost all skeletally immature patients.</description><subject>Bone cancer</subject><subject>Hip dislocation</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Orthopaedic Surgery</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Sarcoma</subject><issn>1434-3916</issn><issn>0936-8051</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kc1u1TAQhSNERUvLC7BAltiwCR3HSRwvUVVopUrddG9N7MklJbYvtiNxX6NPjNuUH7FgM3Mkf3M8mlNVbzl85ADyPAG00NTQtDV0QrQ1f1Gd8LYIoXj_8i99XL1O6R6AN4OCV9WxGCRAL9uT6uHam9mSN8TQW-bQ444c-czCxBKZ4C3GA7M0hejmPFNiOGWKzNEOyduwjyHlr5Rnw4r8MTtc2ERujSzSfkGzmc2epW-0UMZlObDZOcxrJDYGTyxhNMEh22Ox9zmdVUcTLonePPfT6u7z5d3FVX1z--X64tNNbYSEXA84GmNFh31jAdRohFWlWq7QQiuHlkborBw7FKrvhxYHKABverDSikacVh8227L295VS1m5OhpYFPYU1aQEdKCGVekTf_4PehzX6slyhZKO4gCeq2ShTTpIiTXofyzniQXPQj4HpLTBdAtNPgWleht49W6-jI_t75FdCBRAbkMqT31H88_d_bH8C69akKQ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Guder, Wiebke K.</creator><creator>Engel, Nina M.</creator><creator>Streitbürger, Arne</creator><creator>Polan, Christina</creator><creator>Dudda, Marcel</creator><creator>Podleska, Lars E.</creator><creator>Nottrott, Markus</creator><creator>Hardes, Jendrik</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9367-7130</orcidid></search><sort><creationdate>20240601</creationdate><title>Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients</title><author>Guder, Wiebke K. ; Engel, Nina M. ; Streitbürger, Arne ; Polan, Christina ; Dudda, Marcel ; Podleska, Lars E. ; Nottrott, Markus ; Hardes, Jendrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-8abccd35a62d009bc3d99bcd19ad04784eb05d7b5a396684a80d991260d7d323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bone cancer</topic><topic>Hip dislocation</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Orthopaedic Surgery</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Sarcoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guder, Wiebke K.</creatorcontrib><creatorcontrib>Engel, Nina M.</creatorcontrib><creatorcontrib>Streitbürger, Arne</creatorcontrib><creatorcontrib>Polan, Christina</creatorcontrib><creatorcontrib>Dudda, Marcel</creatorcontrib><creatorcontrib>Podleska, Lars E.</creatorcontrib><creatorcontrib>Nottrott, Markus</creatorcontrib><creatorcontrib>Hardes, Jendrik</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of orthopaedic and trauma surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guder, Wiebke K.</au><au>Engel, Nina M.</au><au>Streitbürger, Arne</au><au>Polan, Christina</au><au>Dudda, Marcel</au><au>Podleska, Lars E.</au><au>Nottrott, Markus</au><au>Hardes, Jendrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients</atitle><jtitle>Archives of orthopaedic and trauma surgery</jtitle><stitle>Arch Orthop Trauma Surg</stitle><addtitle>Arch Orthop Trauma Surg</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>144</volume><issue>6</issue><spage>2501</spage><epage>2510</epage><pages>2501-2510</pages><issn>1434-3916</issn><issn>0936-8051</issn><eissn>1434-3916</eissn><abstract>Introduction Megaendoprosthetic reconstruction of bone defects in skeletally immature patients has led to the development of unique complications and secondary deformities not observed in adult patient cohorts. With an increasing number of megaendoprosthetic replacements performed, orthopedic oncologists still gain experience in the incidence and type of secondary deformities caused. In this study, we report the incidence, probable cause and management outcome of two secondary deformities after megaendoprosthetic reconstruction of the proximal femur: hip dysplasia and genu valgum. Materials and methods Retrospective analysis of 14 patients who underwent primary and/or repeat reconstruction/surgery with a megaendoprosthetic proximal femur replacement between 2018 and 2022. Results Mean patient age was 9.1 years (range 4–17 years). Stress shielding was observed in 71.4%. Hip dislocation was the most frequent complication (50%). While four dislocations occurred without an underlying deformity, secondary hip dysplasia was identified in 58.3% ( n  = 7/12) of intraarticular resections and reconstructions, leading to dislocation in 71.4% ( n  = 5/7). A genu valgum deformity was observed in 41.6% ( n  = 5/12). The incidence of secondary hip dysplasia and concomitant genu valgum was 42.9% ( n  = 3/7). Triple pelvic osteotomy led to rebound hip dysplasia in two cases (patients aged &lt; 10 years), whereas acetabular socket replacement led to stable hip joints over the course of follow-up. Temporary hemiepiphyseodesis was applied to address secondary genu valgum. Conclusions Patients aged &lt; 10 years were prone to develop secondary hip dysplasia and genu valgum following proximal femur replacement in this study. Management of secondary deformities should depend on remaining skeletal growth. Stress shielding was observed in almost all skeletally immature patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38700674</pmid><doi>10.1007/s00402-024-05334-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9367-7130</orcidid><oa>free_for_read</oa></addata></record>
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subjects Bone cancer
Hip dislocation
Medicine
Medicine & Public Health
Orthopaedic Surgery
Orthopedics
Patients
Sarcoma
title Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients
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