Functionalized DNA Origami‐Enabled Detection of Biomarkers
Biomarkers are crucial physiological and pathological indicators in the host. Over the years, numerous detection methods have been developed for biomarkers, given their significant potential in various biological and biomedical applications. Among these, the detection system based on functionalized...
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2024-07, Vol.25 (13), p.e202400227-n/a |
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| container_title | Chembiochem : a European journal of chemical biology |
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| creator | Yuan, Caiqing Zhou, Fei Xu, Zhihao Wu, Dunkai Hou, Pengfei Yang, Donglei Pan, Li Wang, Pengfei |
| description | Biomarkers are crucial physiological and pathological indicators in the host. Over the years, numerous detection methods have been developed for biomarkers, given their significant potential in various biological and biomedical applications. Among these, the detection system based on functionalized DNA origami has emerged as a promising approach due to its precise control over sensing modules, enabling sensitive, specific, and programmable biomarker detection. We summarize the advancements in biomarker detection using functionalized DNA origami, focusing on strategies for DNA origami functionalization, mechanisms of biomarker recognition, and applications in disease diagnosis and monitoring. These applications are organized into sections based on the type of biomarkers – nucleic acids, proteins, small molecules, and ions – and concludes with a discussion on the advantages and challenges associated with using functionalized DNA origami systems for biomarker detection.
An emerging field of study involves integrating sensing modules onto DNA origami structures, which allows for the robust detection of a wide range of biomarkers including nucleic acids, proteins, small molecules, and ions. |
| doi_str_mv | 10.1002/cbic.202400227 |
| format | Article |
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Over the years, numerous detection methods have been developed for biomarkers, given their significant potential in various biological and biomedical applications. Among these, the detection system based on functionalized DNA origami has emerged as a promising approach due to its precise control over sensing modules, enabling sensitive, specific, and programmable biomarker detection. We summarize the advancements in biomarker detection using functionalized DNA origami, focusing on strategies for DNA origami functionalization, mechanisms of biomarker recognition, and applications in disease diagnosis and monitoring. These applications are organized into sections based on the type of biomarkers – nucleic acids, proteins, small molecules, and ions – and concludes with a discussion on the advantages and challenges associated with using functionalized DNA origami systems for biomarker detection.
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| source | Wiley Online Library All Journals |
| subjects | biomarker detection Biomarkers Biomedical materials Deoxyribonucleic acid diagnostics DNA DNA self-assembly functionalized DNA origami Nucleic acids |
| title | Functionalized DNA Origami‐Enabled Detection of Biomarkers |
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