Parvalbumin Regulates GAD Expression through Calcium Ion Concentration to Affect the Balance of Glu-GABA and Improve KA-Induced Status Epilepticus in PV-Cre Transgenic Mice

Aims: the study aimed to (i) use adeno-associated virus technology to modulate parvalbumin (PV) gene expression, both through overexpression and silencing, within the hippocampus of male mice and (ii) assess the impact of PV on the metabolic pathway of glutamate and γ-aminobutyric acid (GABA). Metho...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical neuroscience 2024-05, Vol.15 (10), p.1951-1966
Hauptverfasser:	Zeng, Chunmei, Lu, Yuling, Wei, Xing, Sun, Lanfeng, Wei, Lei, Ou, Sijie, Huang, Qi, Wu, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Disease Models, Animal gamma-Aminobutyric Acid - metabolism Glutamate Decarboxylase - metabolism Glutamic Acid - metabolism Hippocampus - metabolism Kainic Acid Male Mice Mice, Transgenic Parvalbumins - metabolism Status Epilepticus - chemically induced Status Epilepticus - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!