Correlation between Serum Levels of Nitric Oxide and Adropin and Erectile Dysfunction in Males with Nonalcoholic Fatty Liver Disease: An Observational Study
The current study aimed to evaluate the serum levels of nitric oxide (NO) and adropin in males with non-alcoholic fatty liver disease (NAFLD) induced erectile dysfunction (ED) and NAFLD patients without ED and controls. The current study selected 165 participants from the hepatology department from...
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| Veröffentlicht in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2024-09, Vol.31 (9), p.2676-2684 |
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| creator | Ragab, Ahmed Fattah, Ali M Abdel Sayed, Ahmed Reda GamalEl Din, Sameh Fayek Mahmoud Hassan, Shrouk Matrawy Mohamed, Aya Yaseen Mohamed Hamed, Mostafa Ahmed |
| description | The current study aimed to evaluate the serum levels of nitric oxide (NO) and adropin in males with non-alcoholic fatty liver disease (NAFLD) induced erectile dysfunction (ED) and NAFLD patients without ED and controls. The current study selected 165 participants from the hepatology department from November 2021 to November 2022. The patients were either suffering from NAFLD with normal liver functions or non-alcoholic steatohepatitis with abnormal liver functions. They were diagnosed by abdominal ultrasonography. Participants were evaluated using the validated Arabic version of the International Index of Erectile Function (ArIIEF-5), the Arabic form of the Generalized Anxiety Disorder-7 (GAD-7) questionnaire and the Patient Health Questionnaire-9 (PHQ-9). Noteworthy, there were significant positive correlations between ArIIEF-5 score, NO, adropin and total testosterone (r = 0.380, p = 0.001; r = 0.507, p = |
| doi_str_mv | 10.1007/s43032-024-01537-4 |
| format | Article |
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The current study selected 165 participants from the hepatology department from November 2021 to November 2022. The patients were either suffering from NAFLD with normal liver functions or non-alcoholic steatohepatitis with abnormal liver functions. They were diagnosed by abdominal ultrasonography. Participants were evaluated using the validated Arabic version of the International Index of Erectile Function (ArIIEF-5), the Arabic form of the Generalized Anxiety Disorder-7 (GAD-7) questionnaire and the Patient Health Questionnaire-9 (PHQ-9). Noteworthy, there were significant positive correlations between ArIIEF-5 score, NO, adropin and total testosterone (r = 0.380, p = 0.001; r = 0.507, p = < 0.001; r = 0.246, p = 0.038, respectively). Meanwhile, there were significant negative correlations between ArIIEF-5 score, creatinine, duration of the disease and scores of GAD-7 and PHQ-9 (r = -0.656, p = < 0.001; r = -0.368, p = 0.002; r = -0.663, p = < 0.001; r = -0.248, p = 0.037, respectively). Finally, a linear regression analysis revealed that GAD-7, creatinine, and adropin were the only strong independent predictors of ArIIEF-5, as the 95% confidence interval in the form of upper and lower bounds was -0.349, -0.843, p < 0.001, -6.507, -18.402, p < 0.001, 0.476, 0.117, and p 0.002, respectively. Impaired NO and adropin levels play a potential role in the development of ED in patients with NAFLD.</description><identifier>ISSN: 1933-7191</identifier><identifier>ISSN: 1933-7205</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1007/s43032-024-01537-4</identifier><identifier>PMID: 38691315</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Biomarkers - blood ; Blood Proteins - analysis ; Blood Proteins - metabolism ; Embryology ; Erectile Dysfunction - blood ; Erectile Dysfunction - diagnosis ; Humans ; Intercellular Signaling Peptides and Proteins - blood ; Male ; Male Reproduction: Original Article ; Medicine ; Medicine & Public Health ; Middle Aged ; Nitric Oxide - blood ; Non-alcoholic Fatty Liver Disease - blood ; Non-alcoholic Fatty Liver Disease - complications ; Obstetrics/Perinatology/Midwifery ; Reproductive Medicine</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2024-09, Vol.31 (9), p.2676-2684</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c342t-c0547bb9832f2e932f1de6532df1731c581ae761bc287a3f23d0f33ab432d8e93</cites><orcidid>0000-0003-1918-5132</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s43032-024-01537-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s43032-024-01537-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38691315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ragab, Ahmed</creatorcontrib><creatorcontrib>Fattah, Ali M Abdel</creatorcontrib><creatorcontrib>Sayed, Ahmed Reda</creatorcontrib><creatorcontrib>GamalEl Din, Sameh Fayek</creatorcontrib><creatorcontrib>Mahmoud Hassan, Shrouk Matrawy</creatorcontrib><creatorcontrib>Mohamed, Aya Yaseen Mohamed</creatorcontrib><creatorcontrib>Hamed, Mostafa Ahmed</creatorcontrib><title>Correlation between Serum Levels of Nitric Oxide and Adropin and Erectile Dysfunction in Males with Nonalcoholic Fatty Liver Disease: An Observational Study</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>The current study aimed to evaluate the serum levels of nitric oxide (NO) and adropin in males with non-alcoholic fatty liver disease (NAFLD) induced erectile dysfunction (ED) and NAFLD patients without ED and controls. The current study selected 165 participants from the hepatology department from November 2021 to November 2022. The patients were either suffering from NAFLD with normal liver functions or non-alcoholic steatohepatitis with abnormal liver functions. They were diagnosed by abdominal ultrasonography. Participants were evaluated using the validated Arabic version of the International Index of Erectile Function (ArIIEF-5), the Arabic form of the Generalized Anxiety Disorder-7 (GAD-7) questionnaire and the Patient Health Questionnaire-9 (PHQ-9). Noteworthy, there were significant positive correlations between ArIIEF-5 score, NO, adropin and total testosterone (r = 0.380, p = 0.001; r = 0.507, p = < 0.001; r = 0.246, p = 0.038, respectively). Meanwhile, there were significant negative correlations between ArIIEF-5 score, creatinine, duration of the disease and scores of GAD-7 and PHQ-9 (r = -0.656, p = < 0.001; r = -0.368, p = 0.002; r = -0.663, p = < 0.001; r = -0.248, p = 0.037, respectively). Finally, a linear regression analysis revealed that GAD-7, creatinine, and adropin were the only strong independent predictors of ArIIEF-5, as the 95% confidence interval in the form of upper and lower bounds was -0.349, -0.843, p < 0.001, -6.507, -18.402, p < 0.001, 0.476, 0.117, and p 0.002, respectively. Impaired NO and adropin levels play a potential role in the development of ED in patients with NAFLD.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood Proteins - analysis</subject><subject>Blood Proteins - metabolism</subject><subject>Embryology</subject><subject>Erectile Dysfunction - blood</subject><subject>Erectile Dysfunction - diagnosis</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Male</subject><subject>Male Reproduction: Original Article</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nitric Oxide - blood</subject><subject>Non-alcoholic Fatty Liver Disease - blood</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Reproductive Medicine</subject><issn>1933-7191</issn><issn>1933-7205</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcFOGzEQhq2qVaG0L9BD5WMv29qe3Xi3tyhAQQrkQHu2vN7ZYuTYqe0Nzbv0YTEJcOQyM9J8_6-xf0I-c_aNMya_pxoYiIqJumK8AVnVb8gx7wAqKVjz9nnmHT8iH1K6Y6ypO9G-J0fQzjoOvDkm_xchRnQ62-Bpj_ke0dMbjNOaLnGLLtEw0mubozV09c8OSLUf6HyIYWP9fj6LaLJ1SE93aZy82TuV3ZV2mOi9zbf0OnjtTLgNrric65x3dGm3GOmpTagT_qBzT1d9wrjdH6IdvcnTsPtI3o3aJfz01E_I7_OzX4uLarn6ebmYLysDtciVKe-Sfd-1IEaBXal8wFkDYhi5BG6almuUM94b0UoNo4CBjQC6rwvSFsEJ-Xrw3cTwd8KU1domg85pj2FKCljDuJSye0TFATUxpBRxVJto1zruFGfqMRV1SEWVVNQ-FVUX0Zcn_6lf4_AieY6hAHAAUln5PxjVXZhi-Yf0mu0D1SyZwA</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Ragab, Ahmed</creator><creator>Fattah, Ali M Abdel</creator><creator>Sayed, Ahmed Reda</creator><creator>GamalEl Din, Sameh Fayek</creator><creator>Mahmoud Hassan, Shrouk Matrawy</creator><creator>Mohamed, Aya Yaseen Mohamed</creator><creator>Hamed, Mostafa Ahmed</creator><general>Springer International Publishing</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1918-5132</orcidid></search><sort><creationdate>20240901</creationdate><title>Correlation between Serum Levels of Nitric Oxide and Adropin and Erectile Dysfunction in Males with Nonalcoholic Fatty Liver Disease: An Observational Study</title><author>Ragab, Ahmed ; Fattah, Ali M Abdel ; Sayed, Ahmed Reda ; GamalEl Din, Sameh Fayek ; Mahmoud Hassan, Shrouk Matrawy ; Mohamed, Aya Yaseen Mohamed ; Hamed, Mostafa Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-c0547bb9832f2e932f1de6532df1731c581ae761bc287a3f23d0f33ab432d8e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood Proteins - analysis</topic><topic>Blood Proteins - metabolism</topic><topic>Embryology</topic><topic>Erectile Dysfunction - blood</topic><topic>Erectile Dysfunction - diagnosis</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Male</topic><topic>Male Reproduction: Original Article</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nitric Oxide - blood</topic><topic>Non-alcoholic Fatty Liver Disease - blood</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Reproductive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ragab, Ahmed</creatorcontrib><creatorcontrib>Fattah, Ali M Abdel</creatorcontrib><creatorcontrib>Sayed, Ahmed Reda</creatorcontrib><creatorcontrib>GamalEl Din, Sameh Fayek</creatorcontrib><creatorcontrib>Mahmoud Hassan, Shrouk Matrawy</creatorcontrib><creatorcontrib>Mohamed, Aya Yaseen Mohamed</creatorcontrib><creatorcontrib>Hamed, Mostafa Ahmed</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ragab, Ahmed</au><au>Fattah, Ali M Abdel</au><au>Sayed, Ahmed Reda</au><au>GamalEl Din, Sameh Fayek</au><au>Mahmoud Hassan, Shrouk Matrawy</au><au>Mohamed, Aya Yaseen Mohamed</au><au>Hamed, Mostafa Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Serum Levels of Nitric Oxide and Adropin and Erectile Dysfunction in Males with Nonalcoholic Fatty Liver Disease: An Observational Study</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>31</volume><issue>9</issue><spage>2676</spage><epage>2684</epage><pages>2676-2684</pages><issn>1933-7191</issn><issn>1933-7205</issn><eissn>1933-7205</eissn><abstract>The current study aimed to evaluate the serum levels of nitric oxide (NO) and adropin in males with non-alcoholic fatty liver disease (NAFLD) induced erectile dysfunction (ED) and NAFLD patients without ED and controls. The current study selected 165 participants from the hepatology department from November 2021 to November 2022. The patients were either suffering from NAFLD with normal liver functions or non-alcoholic steatohepatitis with abnormal liver functions. They were diagnosed by abdominal ultrasonography. Participants were evaluated using the validated Arabic version of the International Index of Erectile Function (ArIIEF-5), the Arabic form of the Generalized Anxiety Disorder-7 (GAD-7) questionnaire and the Patient Health Questionnaire-9 (PHQ-9). Noteworthy, there were significant positive correlations between ArIIEF-5 score, NO, adropin and total testosterone (r = 0.380, p = 0.001; r = 0.507, p = < 0.001; r = 0.246, p = 0.038, respectively). Meanwhile, there were significant negative correlations between ArIIEF-5 score, creatinine, duration of the disease and scores of GAD-7 and PHQ-9 (r = -0.656, p = < 0.001; r = -0.368, p = 0.002; r = -0.663, p = < 0.001; r = -0.248, p = 0.037, respectively). Finally, a linear regression analysis revealed that GAD-7, creatinine, and adropin were the only strong independent predictors of ArIIEF-5, as the 95% confidence interval in the form of upper and lower bounds was -0.349, -0.843, p < 0.001, -6.507, -18.402, p < 0.001, 0.476, 0.117, and p 0.002, respectively. Impaired NO and adropin levels play a potential role in the development of ED in patients with NAFLD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38691315</pmid><doi>10.1007/s43032-024-01537-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1918-5132</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biomarkers - blood Blood Proteins - analysis Blood Proteins - metabolism Embryology Erectile Dysfunction - blood Erectile Dysfunction - diagnosis Humans Intercellular Signaling Peptides and Proteins - blood Male Male Reproduction: Original Article Medicine Medicine & Public Health Middle Aged Nitric Oxide - blood Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - complications Obstetrics/Perinatology/Midwifery Reproductive Medicine |
| title | Correlation between Serum Levels of Nitric Oxide and Adropin and Erectile Dysfunction in Males with Nonalcoholic Fatty Liver Disease: An Observational Study |
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