Pathophysiology and surgical outcomes of patients with fungal peritonitis from upper gastrointestinal tract perforation: a retrospective study
Purpose To compare the pathophysiology and surgical outcomes of emergency surgery for upper gastrointestinal tract perforation with and without fungal peritonitis and identify the risk factors for fungal peritonitis. Methods The subjects of this retrospective study were patients with upper gastroint...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2024-11, Vol.54 (11), p.1345-1352 |
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| creator | Nyumura, Yuya Tsuboi, Kazuto Suzuki, Toshimasa Kajimoto, Tetsuya Tanishima, Yuichiro Yano, Fumiaki Eto, Ken |
| description | Purpose
To compare the pathophysiology and surgical outcomes of emergency surgery for upper gastrointestinal tract perforation with and without fungal peritonitis and identify the risk factors for fungal peritonitis.
Methods
The subjects of this retrospective study were patients with upper gastrointestinal perforation and peritonitis who underwent emergency surgery at a single medical center in Japan. The patients were allocated to two groups according to the presence or absence of fungal peritonitis: group F and group N, respectively.
Results
At the time of surgery, ascitic fluid culture or serum β-D glucan levels were available for 54 patients: 29 from group F and 25 from group N, respectively. The stomach was perforated in 14 patients (25.9%) and the duodenum was perforated in 40 patients (74.1%). Group F had a higher proportion of patients with low preoperative prognostic nutritional index scores (≤ 40) and C-reactive protein levels and a higher postoperative complication rate. The time to initiate food intake and the postoperative hospital stay were also significantly longer in group F. Multivariate analysis identified that the perforation site of the stomach was a risk factor for fungal peritonitis.
Conclusion
Patients with fungal peritonitis from upper gastrointestinal tract perforation had higher postoperative complication rates, delayed postoperative recovery, and a longer hospital stay. Gastric perforation was a risk factor for fungal peritonitis. |
| doi_str_mv | 10.1007/s00595-024-02851-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3050177528</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3050177528</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-2ec730500795eff2b750fc43680e1d1abd143c99e0a0e3ff70f2436bd3b533bd3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi0EotvCC3BAPnIJjO1NE3NDFX8qVYIDnC3HsbOukjh4bNC-BM_MLFs4crBG8vzm08z3MfZCwGsB0L1BgFa3Dcg9vb4VjX7EdmKvrhvZC_WY7UDvRSOkFhfsEvEeiOwBnrIL1V9rISXs2K8vthzSdjhiTHOajtyuI8eap-jszFMtLi0eeQp8syX6tSD_GcuBh7pOBGw-x5LWWCLykNPC60ZffLJYcopr8VjiSlzJ1pUTHVImnbS-5ZZnTxBu3pX4w3MsdTw-Y0-CndE_f6hX7NuH919vPjV3nz_e3ry7a5zUfWmkd52ClkzQrQ9BDl0LwdHlPXgxCjuMZIPT2oMFr0LoIEjqDqMaWqWoXLFXZ90tp--VtjRLROfn2a4-VTQncdF1rewJlWfU0bKYfTBbjovNRyPAnHIw5xwMuWv-5GA0Db180K_D4sd_I3-NJ0CdAaTWOvls7lPNZBX-T_Y37GmYKA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3050177528</pqid></control><display><type>article</type><title>Pathophysiology and surgical outcomes of patients with fungal peritonitis from upper gastrointestinal tract perforation: a retrospective study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Nyumura, Yuya ; Tsuboi, Kazuto ; Suzuki, Toshimasa ; Kajimoto, Tetsuya ; Tanishima, Yuichiro ; Yano, Fumiaki ; Eto, Ken</creator><creatorcontrib>Nyumura, Yuya ; Tsuboi, Kazuto ; Suzuki, Toshimasa ; Kajimoto, Tetsuya ; Tanishima, Yuichiro ; Yano, Fumiaki ; Eto, Ken</creatorcontrib><description>Purpose
To compare the pathophysiology and surgical outcomes of emergency surgery for upper gastrointestinal tract perforation with and without fungal peritonitis and identify the risk factors for fungal peritonitis.
Methods
The subjects of this retrospective study were patients with upper gastrointestinal perforation and peritonitis who underwent emergency surgery at a single medical center in Japan. The patients were allocated to two groups according to the presence or absence of fungal peritonitis: group F and group N, respectively.
Results
At the time of surgery, ascitic fluid culture or serum β-D glucan levels were available for 54 patients: 29 from group F and 25 from group N, respectively. The stomach was perforated in 14 patients (25.9%) and the duodenum was perforated in 40 patients (74.1%). Group F had a higher proportion of patients with low preoperative prognostic nutritional index scores (≤ 40) and C-reactive protein levels and a higher postoperative complication rate. The time to initiate food intake and the postoperative hospital stay were also significantly longer in group F. Multivariate analysis identified that the perforation site of the stomach was a risk factor for fungal peritonitis.
Conclusion
Patients with fungal peritonitis from upper gastrointestinal tract perforation had higher postoperative complication rates, delayed postoperative recovery, and a longer hospital stay. Gastric perforation was a risk factor for fungal peritonitis.</description><identifier>ISSN: 0941-1291</identifier><identifier>ISSN: 1436-2813</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-024-02851-9</identifier><identifier>PMID: 38691220</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Aged ; Aged, 80 and over ; C-Reactive Protein - analysis ; Female ; Humans ; Intestinal Perforation - etiology ; Intestinal Perforation - surgery ; Length of Stay ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mycoses - complications ; Original Article ; Peritonitis - etiology ; Peritonitis - microbiology ; Peritonitis - surgery ; Postoperative Complications - etiology ; Retrospective Studies ; Risk Factors ; Surgery ; Surgical Oncology ; Treatment Outcome</subject><ispartof>Surgery today (Tokyo, Japan), 2024-11, Vol.54 (11), p.1345-1352</ispartof><rights>The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-2ec730500795eff2b750fc43680e1d1abd143c99e0a0e3ff70f2436bd3b533bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-024-02851-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-024-02851-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38691220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyumura, Yuya</creatorcontrib><creatorcontrib>Tsuboi, Kazuto</creatorcontrib><creatorcontrib>Suzuki, Toshimasa</creatorcontrib><creatorcontrib>Kajimoto, Tetsuya</creatorcontrib><creatorcontrib>Tanishima, Yuichiro</creatorcontrib><creatorcontrib>Yano, Fumiaki</creatorcontrib><creatorcontrib>Eto, Ken</creatorcontrib><title>Pathophysiology and surgical outcomes of patients with fungal peritonitis from upper gastrointestinal tract perforation: a retrospective study</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
To compare the pathophysiology and surgical outcomes of emergency surgery for upper gastrointestinal tract perforation with and without fungal peritonitis and identify the risk factors for fungal peritonitis.
Methods
The subjects of this retrospective study were patients with upper gastrointestinal perforation and peritonitis who underwent emergency surgery at a single medical center in Japan. The patients were allocated to two groups according to the presence or absence of fungal peritonitis: group F and group N, respectively.
Results
At the time of surgery, ascitic fluid culture or serum β-D glucan levels were available for 54 patients: 29 from group F and 25 from group N, respectively. The stomach was perforated in 14 patients (25.9%) and the duodenum was perforated in 40 patients (74.1%). Group F had a higher proportion of patients with low preoperative prognostic nutritional index scores (≤ 40) and C-reactive protein levels and a higher postoperative complication rate. The time to initiate food intake and the postoperative hospital stay were also significantly longer in group F. Multivariate analysis identified that the perforation site of the stomach was a risk factor for fungal peritonitis.
Conclusion
Patients with fungal peritonitis from upper gastrointestinal tract perforation had higher postoperative complication rates, delayed postoperative recovery, and a longer hospital stay. Gastric perforation was a risk factor for fungal peritonitis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>C-Reactive Protein - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Perforation - etiology</subject><subject>Intestinal Perforation - surgery</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mycoses - complications</subject><subject>Original Article</subject><subject>Peritonitis - etiology</subject><subject>Peritonitis - microbiology</subject><subject>Peritonitis - surgery</subject><subject>Postoperative Complications - etiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Treatment Outcome</subject><issn>0941-1291</issn><issn>1436-2813</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EotvCC3BAPnIJjO1NE3NDFX8qVYIDnC3HsbOukjh4bNC-BM_MLFs4crBG8vzm08z3MfZCwGsB0L1BgFa3Dcg9vb4VjX7EdmKvrhvZC_WY7UDvRSOkFhfsEvEeiOwBnrIL1V9rISXs2K8vthzSdjhiTHOajtyuI8eap-jszFMtLi0eeQp8syX6tSD_GcuBh7pOBGw-x5LWWCLykNPC60ZffLJYcopr8VjiSlzJ1pUTHVImnbS-5ZZnTxBu3pX4w3MsdTw-Y0-CndE_f6hX7NuH919vPjV3nz_e3ry7a5zUfWmkd52ClkzQrQ9BDl0LwdHlPXgxCjuMZIPT2oMFr0LoIEjqDqMaWqWoXLFXZ90tp--VtjRLROfn2a4-VTQncdF1rewJlWfU0bKYfTBbjovNRyPAnHIw5xwMuWv-5GA0Db180K_D4sd_I3-NJ0CdAaTWOvls7lPNZBX-T_Y37GmYKA</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Nyumura, Yuya</creator><creator>Tsuboi, Kazuto</creator><creator>Suzuki, Toshimasa</creator><creator>Kajimoto, Tetsuya</creator><creator>Tanishima, Yuichiro</creator><creator>Yano, Fumiaki</creator><creator>Eto, Ken</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>Pathophysiology and surgical outcomes of patients with fungal peritonitis from upper gastrointestinal tract perforation: a retrospective study</title><author>Nyumura, Yuya ; Tsuboi, Kazuto ; Suzuki, Toshimasa ; Kajimoto, Tetsuya ; Tanishima, Yuichiro ; Yano, Fumiaki ; Eto, Ken</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-2ec730500795eff2b750fc43680e1d1abd143c99e0a0e3ff70f2436bd3b533bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>C-Reactive Protein - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Perforation - etiology</topic><topic>Intestinal Perforation - surgery</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mycoses - complications</topic><topic>Original Article</topic><topic>Peritonitis - etiology</topic><topic>Peritonitis - microbiology</topic><topic>Peritonitis - surgery</topic><topic>Postoperative Complications - etiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyumura, Yuya</creatorcontrib><creatorcontrib>Tsuboi, Kazuto</creatorcontrib><creatorcontrib>Suzuki, Toshimasa</creatorcontrib><creatorcontrib>Kajimoto, Tetsuya</creatorcontrib><creatorcontrib>Tanishima, Yuichiro</creatorcontrib><creatorcontrib>Yano, Fumiaki</creatorcontrib><creatorcontrib>Eto, Ken</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nyumura, Yuya</au><au>Tsuboi, Kazuto</au><au>Suzuki, Toshimasa</au><au>Kajimoto, Tetsuya</au><au>Tanishima, Yuichiro</au><au>Yano, Fumiaki</au><au>Eto, Ken</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathophysiology and surgical outcomes of patients with fungal peritonitis from upper gastrointestinal tract perforation: a retrospective study</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>54</volume><issue>11</issue><spage>1345</spage><epage>1352</epage><pages>1345-1352</pages><issn>0941-1291</issn><issn>1436-2813</issn><eissn>1436-2813</eissn><abstract>Purpose
To compare the pathophysiology and surgical outcomes of emergency surgery for upper gastrointestinal tract perforation with and without fungal peritonitis and identify the risk factors for fungal peritonitis.
Methods
The subjects of this retrospective study were patients with upper gastrointestinal perforation and peritonitis who underwent emergency surgery at a single medical center in Japan. The patients were allocated to two groups according to the presence or absence of fungal peritonitis: group F and group N, respectively.
Results
At the time of surgery, ascitic fluid culture or serum β-D glucan levels were available for 54 patients: 29 from group F and 25 from group N, respectively. The stomach was perforated in 14 patients (25.9%) and the duodenum was perforated in 40 patients (74.1%). Group F had a higher proportion of patients with low preoperative prognostic nutritional index scores (≤ 40) and C-reactive protein levels and a higher postoperative complication rate. The time to initiate food intake and the postoperative hospital stay were also significantly longer in group F. Multivariate analysis identified that the perforation site of the stomach was a risk factor for fungal peritonitis.
Conclusion
Patients with fungal peritonitis from upper gastrointestinal tract perforation had higher postoperative complication rates, delayed postoperative recovery, and a longer hospital stay. Gastric perforation was a risk factor for fungal peritonitis.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38691220</pmid><doi>10.1007/s00595-024-02851-9</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over C-Reactive Protein - analysis Female Humans Intestinal Perforation - etiology Intestinal Perforation - surgery Length of Stay Male Medicine Medicine & Public Health Middle Aged Mycoses - complications Original Article Peritonitis - etiology Peritonitis - microbiology Peritonitis - surgery Postoperative Complications - etiology Retrospective Studies Risk Factors Surgery Surgical Oncology Treatment Outcome |
| title | Pathophysiology and surgical outcomes of patients with fungal peritonitis from upper gastrointestinal tract perforation: a retrospective study |
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