ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension
Idiopathic pulmonary arterial hypertension (IPAH) represents an important clinical indication for lung transplant (LTx) in children. Recent trends show fewer children with IPAH are undergoing LTx nowadays compared to previous time periods, including those with most severe form of the disease. Using...
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| Veröffentlicht in: | Lung 2024-10, Vol.202 (5), p.753-755 |
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| creator | Ahmed, Hosam F. Morales, David L. S. Hayes, Don |
| description | Idiopathic pulmonary arterial hypertension (IPAH) represents an important clinical indication for lung transplant (LTx) in children. Recent trends show fewer children with IPAH are undergoing LTx nowadays compared to previous time periods, including those with most severe form of the disease. Using the UNOS Registry, we investigated if ECMO at the time of transplant impacts post-transplant survival in children with IPAH. A total of 74 LTx recipients while on ECMO at the time of transplant were identified (IPAH: N = 12). Children with IPAH who underwent LTx while on ECMO had shown comparable survival rates to those who were on ECMO for other conditions. This analysis provides encouraging results, supporting the potential expansion of LTx for this patient population. Given the low number of children undergoing LTx, we think there should be a consensus document to provide better guidance for referring and selecting the high-risk pediatric population with IPAH on ECMO for lung transplant. |
| doi_str_mv | 10.1007/s00408-024-00703-4 |
| format | Article |
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| subjects | Adolescent Child Child, Preschool Children Correspondence Extracorporeal Membrane Oxygenation Familial Primary Pulmonary Hypertension - physiopathology Familial Primary Pulmonary Hypertension - surgery Female Humans Hypertension Infant Lung Transplantation Lung transplants Lungs Male Medicine Medicine & Public Health Pediatrics Pneumology/Respiratory System Pulmonary hypertension Registries Retrospective Studies Survival Survival Rate Treatment Outcome |
| title | ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension |
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