3D genomic mapping reveals multifocality of human pancreatic precancers

Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of pancreatic cancer, but their small size and inaccessibility in humans make them challenging to study 1 . Critically, the number, dimensions and connectivity of human PanINs remain largely unknown, precluding important i...

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Veröffentlicht in:	Nature (London) 2024-05, Vol.629 (8012), p.679-687
Hauptverfasser:	Braxton, Alicia M., Kiemen, Ashley L., Grahn, Mia P., Forjaz, André, Parksong, Jeeun, Mahesh Babu, Jaanvi, Lai, Jiaying, Zheng, Lily, Niknafs, Noushin, Jiang, Liping, Cheng, Haixia, Song, Qianqian, Reichel, Rebecca, Graham, Sarah, Damanakis, Alexander I., Fischer, Catherine G., Mou, Stephanie, Metz, Cameron, Granger, Julie, Liu, Xiao-Ding, Bachmann, Niklas, Zhu, Yutong, Liu, YunZhou, Almagro-Pérez, Cristina, Jiang, Ann Chenyu, Yoo, Jeonghyun, Kim, Bridgette, Du, Scott, Foster, Eli, Hsu, Jocelyn Y., Rivera, Paula Andreu, Chu, Linda C., Liu, Fengze, Fishman, Elliot K., Yuille, Alan, Roberts, Nicholas J., Thompson, Elizabeth D., Scharpf, Robert B., Cornish, Toby C., Jiao, Yuchen, Karchin, Rachel, Hruban, Ralph H., Wu, Pei-Hsun, Wirtz, Denis, Wood, Laura D.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/71 45 45/23 631/67/1504/1713 631/67/69 639/705/1042 Adult Cancer Carcinoma in Situ - genetics Carcinoma in Situ - pathology Clone Cells - cytology Clone Cells - metabolism Connectivity Empirical analysis Exome Sequencing Female Females Gene mapping Genetic Heterogeneity Genetic relationship Genomics Heterogeneity Humanities and Social Sciences Humans Imaging, Three-Dimensional Interception K-Ras protein Machine Learning Male Mapping multidisciplinary Mutation Mutation hot spots Neoplasms Pancreas Pancreas - cytology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Precancerous Conditions - genetics Precancerous Conditions - pathology Proto-Oncogene Proteins p21(ras) - genetics Science Science (multidisciplinary) Single-Cell Analysis Subpopulations Tumors Workflow
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