Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry
Abstract Aims Evaluation of left and right ventricular (RV) longitudinal systolic function may enhance risk stratification following aortic valve replacement (AVR). The study objective was to evaluate the changes in left and RV longitudinal systolic function and RV–pulmonary artery (RV–PA) coupling...
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| Veröffentlicht in: | European heart journal cardiovascular imaging 2024-08, Vol.25 (9), p.1276-1286 |
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| creator | Silva, Iria Ternacle, Julien Hahn, Rebecca T Salah-Annabi, Mohamed Dahou, Abdellaziz Krapf, Laura Salaun, Erwan Guzzetti, Ezequiel Xu, Ke Clavel, Marie-Annick Bernier, Mathieu Beaudoin, Jonathan Cremer, Paul C Jaber, Wael Rodriguez, Leonardo Asch, Federico M Weismann, Neil J Bax, Jeroen Ajmone, Nina Alu, Maria C Kallel, Faouzi Mack, Michael J Webb, John G Kapadia, Samir Makkar, Raj Kodali, Susheel Herrmann, Howard C Thourani, Vinod Leon, Martin B Pibarot, Philippe |
| description | Abstract
Aims
Evaluation of left and right ventricular (RV) longitudinal systolic function may enhance risk stratification following aortic valve replacement (AVR). The study objective was to evaluate the changes in left and RV longitudinal systolic function and RV–pulmonary artery (RV–PA) coupling from baseline to 30 days and 1 year after AVR.
Methods and results
Left ventricular (LV) longitudinal strain (LS), tricuspid annulus plane systolic excursion (TAPSE), and RV–PA coupling were evaluated in patients from the PARTNER 2A surgical AVR (SAVR) arm (n = 985) and from the PARTNER 2 SAPIEN 3 registry (n = 719). TAPSE and RV–PA coupling decreased significantly following SAVR, but remained stable following TAVR. Lower LV LS, TAPSE, or RV–PA coupling at baseline was associated with increased risk of the composite of death, hospitalization, and stroke at 5 years [adjusted hazard ratios (HRs) for LV LS < 15%: 1.24, 95% confidence interval (CI) 1.05–1.45, P = 0.001; TAPSE < 14 mm: 1.44, 95% CI 1.21–1.73, P < 0.001; RV–PA coupling < 0.55 mm/mmHg: 1.32, 95% CI 1.07–1.63, P = 0.011]. Reduced TAPSE at baseline was the most powerful predictor of the composite endpoint at 5 years. Patients with LV ejection fraction |
| doi_str_mv | 10.1093/ehjci/jeae114 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3050173789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ehjci/jeae114</oup_id><sourcerecordid>3050173789</sourcerecordid><originalsourceid>FETCH-LOGICAL-c212t-806f26bc5c64ee4fde792aa31f819da195049dfc394c66d23100e11a90def7ca3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMoKrVHr5Kjl7VJNt1tjiJ-QVGRel7S7KRNSZOaZCu9-dONttajA8MMzMsz8CB0TskVJaIcwHyhzGABEijlB-iUEV4XjFN2uN8JP0H9GBck15BXnNFjdFKOKpG7OkWfY9AJS9fiYGbzhNfgUjCqszJg693MpK41TlocNzF5axTWnVPJeIe1t9Z_GDfD0oeUL2tp14ADrKxUsMwgbBxOc8Av16-Tp9tXzHBmZ9bPO5iZmMLmDB1paSP0d7OH3u5uJzcPxfj5_vHmelwoRlkqRqTSrJqqoao4ANct1IJJWVI9oqKVVAwJF61WpeCqqlpWUkKyFClIC7pWsuyhyy13Ffx7BzE1SxMVWCsd-C42JRkSWpf1SORosY2q4GMMoJtVMEsZNg0lzbf35sd7s_Oe8xc7dDddQrtP_1r---271T-sL1Z4j9s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3050173789</pqid></control><display><type>article</type><title>Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Silva, Iria ; Ternacle, Julien ; Hahn, Rebecca T ; Salah-Annabi, Mohamed ; Dahou, Abdellaziz ; Krapf, Laura ; Salaun, Erwan ; Guzzetti, Ezequiel ; Xu, Ke ; Clavel, Marie-Annick ; Bernier, Mathieu ; Beaudoin, Jonathan ; Cremer, Paul C ; Jaber, Wael ; Rodriguez, Leonardo ; Asch, Federico M ; Weismann, Neil J ; Bax, Jeroen ; Ajmone, Nina ; Alu, Maria C ; Kallel, Faouzi ; Mack, Michael J ; Webb, John G ; Kapadia, Samir ; Makkar, Raj ; Kodali, Susheel ; Herrmann, Howard C ; Thourani, Vinod ; Leon, Martin B ; Pibarot, Philippe</creator><creatorcontrib>Silva, Iria ; Ternacle, Julien ; Hahn, Rebecca T ; Salah-Annabi, Mohamed ; Dahou, Abdellaziz ; Krapf, Laura ; Salaun, Erwan ; Guzzetti, Ezequiel ; Xu, Ke ; Clavel, Marie-Annick ; Bernier, Mathieu ; Beaudoin, Jonathan ; Cremer, Paul C ; Jaber, Wael ; Rodriguez, Leonardo ; Asch, Federico M ; Weismann, Neil J ; Bax, Jeroen ; Ajmone, Nina ; Alu, Maria C ; Kallel, Faouzi ; Mack, Michael J ; Webb, John G ; Kapadia, Samir ; Makkar, Raj ; Kodali, Susheel ; Herrmann, Howard C ; Thourani, Vinod ; Leon, Martin B ; Pibarot, Philippe</creatorcontrib><description><![CDATA[Abstract
Aims
Evaluation of left and right ventricular (RV) longitudinal systolic function may enhance risk stratification following aortic valve replacement (AVR). The study objective was to evaluate the changes in left and RV longitudinal systolic function and RV–pulmonary artery (RV–PA) coupling from baseline to 30 days and 1 year after AVR.
Methods and results
Left ventricular (LV) longitudinal strain (LS), tricuspid annulus plane systolic excursion (TAPSE), and RV–PA coupling were evaluated in patients from the PARTNER 2A surgical AVR (SAVR) arm (n = 985) and from the PARTNER 2 SAPIEN 3 registry (n = 719). TAPSE and RV–PA coupling decreased significantly following SAVR, but remained stable following TAVR. Lower LV LS, TAPSE, or RV–PA coupling at baseline was associated with increased risk of the composite of death, hospitalization, and stroke at 5 years [adjusted hazard ratios (HRs) for LV LS < 15%: 1.24, 95% confidence interval (CI) 1.05–1.45, P = 0.001; TAPSE < 14 mm: 1.44, 95% CI 1.21–1.73, P < 0.001; RV–PA coupling < 0.55 mm/mmHg: 1.32, 95% CI 1.07–1.63, P = 0.011]. Reduced TAPSE at baseline was the most powerful predictor of the composite endpoint at 5 years. Patients with LV ejection fraction <50% at baseline had increased risk of the primary endpoint with SAVR (HR: 1.34, 95% CI 1.08–1.68, P = 0.009) but not with TAVR (HR: 1.12, 95% CI 0.88–1.42). Lower RV–PA coupling at 30 days showed the strongest association with cardiac mortality.
Conclusion
SAVR but not TAVR was associated with a marked deterioration in RV longitudinal systolic function and RV–PA coupling. Lower TAPSE and RV–PA coupling at 30 days were associated with inferior clinical outcomes at 5 years. In patients with LVEF < 50%, TAVR was associated with superior 5-year outcomes.
Graphical Abstract
Graphical Abstract]]></description><identifier>ISSN: 2047-2404</identifier><identifier>ISSN: 2047-2412</identifier><identifier>EISSN: 2047-2412</identifier><identifier>DOI: 10.1093/ehjci/jeae114</identifier><identifier>PMID: 38693866</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Aortic Valve Stenosis - diagnostic imaging ; Aortic Valve Stenosis - physiopathology ; Aortic Valve Stenosis - surgery ; Echocardiography ; Female ; Heart Valve Prosthesis Implantation - adverse effects ; Heart Valve Prosthesis Implantation - methods ; Humans ; Male ; Registries ; Risk Assessment ; Stroke Volume - physiology ; Systole ; Transcatheter Aortic Valve Replacement - adverse effects ; Transcatheter Aortic Valve Replacement - methods ; Treatment Outcome ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>European heart journal cardiovascular imaging, 2024-08, Vol.25 (9), p.1276-1286</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c212t-806f26bc5c64ee4fde792aa31f819da195049dfc394c66d23100e11a90def7ca3</cites><orcidid>0000-0002-9914-6821 ; 0000-0002-3607-279X ; 0000-0002-8924-740X ; 0000-0002-9629-5864 ; 0000-0002-6613-519X ; 0000-0002-2984-5512 ; 0000-0002-0026-3391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38693866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Iria</creatorcontrib><creatorcontrib>Ternacle, Julien</creatorcontrib><creatorcontrib>Hahn, Rebecca T</creatorcontrib><creatorcontrib>Salah-Annabi, Mohamed</creatorcontrib><creatorcontrib>Dahou, Abdellaziz</creatorcontrib><creatorcontrib>Krapf, Laura</creatorcontrib><creatorcontrib>Salaun, Erwan</creatorcontrib><creatorcontrib>Guzzetti, Ezequiel</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Clavel, Marie-Annick</creatorcontrib><creatorcontrib>Bernier, Mathieu</creatorcontrib><creatorcontrib>Beaudoin, Jonathan</creatorcontrib><creatorcontrib>Cremer, Paul C</creatorcontrib><creatorcontrib>Jaber, Wael</creatorcontrib><creatorcontrib>Rodriguez, Leonardo</creatorcontrib><creatorcontrib>Asch, Federico M</creatorcontrib><creatorcontrib>Weismann, Neil J</creatorcontrib><creatorcontrib>Bax, Jeroen</creatorcontrib><creatorcontrib>Ajmone, Nina</creatorcontrib><creatorcontrib>Alu, Maria C</creatorcontrib><creatorcontrib>Kallel, Faouzi</creatorcontrib><creatorcontrib>Mack, Michael J</creatorcontrib><creatorcontrib>Webb, John G</creatorcontrib><creatorcontrib>Kapadia, Samir</creatorcontrib><creatorcontrib>Makkar, Raj</creatorcontrib><creatorcontrib>Kodali, Susheel</creatorcontrib><creatorcontrib>Herrmann, Howard C</creatorcontrib><creatorcontrib>Thourani, Vinod</creatorcontrib><creatorcontrib>Leon, Martin B</creatorcontrib><creatorcontrib>Pibarot, Philippe</creatorcontrib><title>Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry</title><title>European heart journal cardiovascular imaging</title><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><description><![CDATA[Abstract
Aims
Evaluation of left and right ventricular (RV) longitudinal systolic function may enhance risk stratification following aortic valve replacement (AVR). The study objective was to evaluate the changes in left and RV longitudinal systolic function and RV–pulmonary artery (RV–PA) coupling from baseline to 30 days and 1 year after AVR.
Methods and results
Left ventricular (LV) longitudinal strain (LS), tricuspid annulus plane systolic excursion (TAPSE), and RV–PA coupling were evaluated in patients from the PARTNER 2A surgical AVR (SAVR) arm (n = 985) and from the PARTNER 2 SAPIEN 3 registry (n = 719). TAPSE and RV–PA coupling decreased significantly following SAVR, but remained stable following TAVR. Lower LV LS, TAPSE, or RV–PA coupling at baseline was associated with increased risk of the composite of death, hospitalization, and stroke at 5 years [adjusted hazard ratios (HRs) for LV LS < 15%: 1.24, 95% confidence interval (CI) 1.05–1.45, P = 0.001; TAPSE < 14 mm: 1.44, 95% CI 1.21–1.73, P < 0.001; RV–PA coupling < 0.55 mm/mmHg: 1.32, 95% CI 1.07–1.63, P = 0.011]. Reduced TAPSE at baseline was the most powerful predictor of the composite endpoint at 5 years. Patients with LV ejection fraction <50% at baseline had increased risk of the primary endpoint with SAVR (HR: 1.34, 95% CI 1.08–1.68, P = 0.009) but not with TAVR (HR: 1.12, 95% CI 0.88–1.42). Lower RV–PA coupling at 30 days showed the strongest association with cardiac mortality.
Conclusion
SAVR but not TAVR was associated with a marked deterioration in RV longitudinal systolic function and RV–PA coupling. Lower TAPSE and RV–PA coupling at 30 days were associated with inferior clinical outcomes at 5 years. In patients with LVEF < 50%, TAVR was associated with superior 5-year outcomes.
Graphical Abstract
Graphical Abstract]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic Valve Stenosis - diagnostic imaging</subject><subject>Aortic Valve Stenosis - physiopathology</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Valve Prosthesis Implantation - adverse effects</subject><subject>Heart Valve Prosthesis Implantation - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Stroke Volume - physiology</subject><subject>Systole</subject><subject>Transcatheter Aortic Valve Replacement - adverse effects</subject><subject>Transcatheter Aortic Valve Replacement - methods</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>2047-2404</issn><issn>2047-2412</issn><issn>2047-2412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoKrVHr5Kjl7VJNt1tjiJ-QVGRel7S7KRNSZOaZCu9-dONttajA8MMzMsz8CB0TskVJaIcwHyhzGABEijlB-iUEV4XjFN2uN8JP0H9GBck15BXnNFjdFKOKpG7OkWfY9AJS9fiYGbzhNfgUjCqszJg693MpK41TlocNzF5axTWnVPJeIe1t9Z_GDfD0oeUL2tp14ADrKxUsMwgbBxOc8Av16-Tp9tXzHBmZ9bPO5iZmMLmDB1paSP0d7OH3u5uJzcPxfj5_vHmelwoRlkqRqTSrJqqoao4ANct1IJJWVI9oqKVVAwJF61WpeCqqlpWUkKyFClIC7pWsuyhyy13Ffx7BzE1SxMVWCsd-C42JRkSWpf1SORosY2q4GMMoJtVMEsZNg0lzbf35sd7s_Oe8xc7dDddQrtP_1r---271T-sL1Z4j9s</recordid><startdate>20240826</startdate><enddate>20240826</enddate><creator>Silva, Iria</creator><creator>Ternacle, Julien</creator><creator>Hahn, Rebecca T</creator><creator>Salah-Annabi, Mohamed</creator><creator>Dahou, Abdellaziz</creator><creator>Krapf, Laura</creator><creator>Salaun, Erwan</creator><creator>Guzzetti, Ezequiel</creator><creator>Xu, Ke</creator><creator>Clavel, Marie-Annick</creator><creator>Bernier, Mathieu</creator><creator>Beaudoin, Jonathan</creator><creator>Cremer, Paul C</creator><creator>Jaber, Wael</creator><creator>Rodriguez, Leonardo</creator><creator>Asch, Federico M</creator><creator>Weismann, Neil J</creator><creator>Bax, Jeroen</creator><creator>Ajmone, Nina</creator><creator>Alu, Maria C</creator><creator>Kallel, Faouzi</creator><creator>Mack, Michael J</creator><creator>Webb, John G</creator><creator>Kapadia, Samir</creator><creator>Makkar, Raj</creator><creator>Kodali, Susheel</creator><creator>Herrmann, Howard C</creator><creator>Thourani, Vinod</creator><creator>Leon, Martin B</creator><creator>Pibarot, Philippe</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9914-6821</orcidid><orcidid>https://orcid.org/0000-0002-3607-279X</orcidid><orcidid>https://orcid.org/0000-0002-8924-740X</orcidid><orcidid>https://orcid.org/0000-0002-9629-5864</orcidid><orcidid>https://orcid.org/0000-0002-6613-519X</orcidid><orcidid>https://orcid.org/0000-0002-2984-5512</orcidid><orcidid>https://orcid.org/0000-0002-0026-3391</orcidid></search><sort><creationdate>20240826</creationdate><title>Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry</title><author>Silva, Iria ; Ternacle, Julien ; Hahn, Rebecca T ; Salah-Annabi, Mohamed ; Dahou, Abdellaziz ; Krapf, Laura ; Salaun, Erwan ; Guzzetti, Ezequiel ; Xu, Ke ; Clavel, Marie-Annick ; Bernier, Mathieu ; Beaudoin, Jonathan ; Cremer, Paul C ; Jaber, Wael ; Rodriguez, Leonardo ; Asch, Federico M ; Weismann, Neil J ; Bax, Jeroen ; Ajmone, Nina ; Alu, Maria C ; Kallel, Faouzi ; Mack, Michael J ; Webb, John G ; Kapadia, Samir ; Makkar, Raj ; Kodali, Susheel ; Herrmann, Howard C ; Thourani, Vinod ; Leon, Martin B ; Pibarot, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c212t-806f26bc5c64ee4fde792aa31f819da195049dfc394c66d23100e11a90def7ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic Valve Stenosis - diagnostic imaging</topic><topic>Aortic Valve Stenosis - physiopathology</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Valve Prosthesis Implantation - adverse effects</topic><topic>Heart Valve Prosthesis Implantation - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Stroke Volume - physiology</topic><topic>Systole</topic><topic>Transcatheter Aortic Valve Replacement - adverse effects</topic><topic>Transcatheter Aortic Valve Replacement - methods</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Iria</creatorcontrib><creatorcontrib>Ternacle, Julien</creatorcontrib><creatorcontrib>Hahn, Rebecca T</creatorcontrib><creatorcontrib>Salah-Annabi, Mohamed</creatorcontrib><creatorcontrib>Dahou, Abdellaziz</creatorcontrib><creatorcontrib>Krapf, Laura</creatorcontrib><creatorcontrib>Salaun, Erwan</creatorcontrib><creatorcontrib>Guzzetti, Ezequiel</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Clavel, Marie-Annick</creatorcontrib><creatorcontrib>Bernier, Mathieu</creatorcontrib><creatorcontrib>Beaudoin, Jonathan</creatorcontrib><creatorcontrib>Cremer, Paul C</creatorcontrib><creatorcontrib>Jaber, Wael</creatorcontrib><creatorcontrib>Rodriguez, Leonardo</creatorcontrib><creatorcontrib>Asch, Federico M</creatorcontrib><creatorcontrib>Weismann, Neil J</creatorcontrib><creatorcontrib>Bax, Jeroen</creatorcontrib><creatorcontrib>Ajmone, Nina</creatorcontrib><creatorcontrib>Alu, Maria C</creatorcontrib><creatorcontrib>Kallel, Faouzi</creatorcontrib><creatorcontrib>Mack, Michael J</creatorcontrib><creatorcontrib>Webb, John G</creatorcontrib><creatorcontrib>Kapadia, Samir</creatorcontrib><creatorcontrib>Makkar, Raj</creatorcontrib><creatorcontrib>Kodali, Susheel</creatorcontrib><creatorcontrib>Herrmann, Howard C</creatorcontrib><creatorcontrib>Thourani, Vinod</creatorcontrib><creatorcontrib>Leon, Martin B</creatorcontrib><creatorcontrib>Pibarot, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Iria</au><au>Ternacle, Julien</au><au>Hahn, Rebecca T</au><au>Salah-Annabi, Mohamed</au><au>Dahou, Abdellaziz</au><au>Krapf, Laura</au><au>Salaun, Erwan</au><au>Guzzetti, Ezequiel</au><au>Xu, Ke</au><au>Clavel, Marie-Annick</au><au>Bernier, Mathieu</au><au>Beaudoin, Jonathan</au><au>Cremer, Paul C</au><au>Jaber, Wael</au><au>Rodriguez, Leonardo</au><au>Asch, Federico M</au><au>Weismann, Neil J</au><au>Bax, Jeroen</au><au>Ajmone, Nina</au><au>Alu, Maria C</au><au>Kallel, Faouzi</au><au>Mack, Michael J</au><au>Webb, John G</au><au>Kapadia, Samir</au><au>Makkar, Raj</au><au>Kodali, Susheel</au><au>Herrmann, Howard C</au><au>Thourani, Vinod</au><au>Leon, Martin B</au><au>Pibarot, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry</atitle><jtitle>European heart journal cardiovascular imaging</jtitle><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><date>2024-08-26</date><risdate>2024</risdate><volume>25</volume><issue>9</issue><spage>1276</spage><epage>1286</epage><pages>1276-1286</pages><issn>2047-2404</issn><issn>2047-2412</issn><eissn>2047-2412</eissn><abstract><![CDATA[Abstract
Aims
Evaluation of left and right ventricular (RV) longitudinal systolic function may enhance risk stratification following aortic valve replacement (AVR). The study objective was to evaluate the changes in left and RV longitudinal systolic function and RV–pulmonary artery (RV–PA) coupling from baseline to 30 days and 1 year after AVR.
Methods and results
Left ventricular (LV) longitudinal strain (LS), tricuspid annulus plane systolic excursion (TAPSE), and RV–PA coupling were evaluated in patients from the PARTNER 2A surgical AVR (SAVR) arm (n = 985) and from the PARTNER 2 SAPIEN 3 registry (n = 719). TAPSE and RV–PA coupling decreased significantly following SAVR, but remained stable following TAVR. Lower LV LS, TAPSE, or RV–PA coupling at baseline was associated with increased risk of the composite of death, hospitalization, and stroke at 5 years [adjusted hazard ratios (HRs) for LV LS < 15%: 1.24, 95% confidence interval (CI) 1.05–1.45, P = 0.001; TAPSE < 14 mm: 1.44, 95% CI 1.21–1.73, P < 0.001; RV–PA coupling < 0.55 mm/mmHg: 1.32, 95% CI 1.07–1.63, P = 0.011]. Reduced TAPSE at baseline was the most powerful predictor of the composite endpoint at 5 years. Patients with LV ejection fraction <50% at baseline had increased risk of the primary endpoint with SAVR (HR: 1.34, 95% CI 1.08–1.68, P = 0.009) but not with TAVR (HR: 1.12, 95% CI 0.88–1.42). Lower RV–PA coupling at 30 days showed the strongest association with cardiac mortality.
Conclusion
SAVR but not TAVR was associated with a marked deterioration in RV longitudinal systolic function and RV–PA coupling. Lower TAPSE and RV–PA coupling at 30 days were associated with inferior clinical outcomes at 5 years. In patients with LVEF < 50%, TAVR was associated with superior 5-year outcomes.
Graphical Abstract
Graphical Abstract]]></abstract><cop>UK</cop><pub>Oxford University Press</pub><pmid>38693866</pmid><doi>10.1093/ehjci/jeae114</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9914-6821</orcidid><orcidid>https://orcid.org/0000-0002-3607-279X</orcidid><orcidid>https://orcid.org/0000-0002-8924-740X</orcidid><orcidid>https://orcid.org/0000-0002-9629-5864</orcidid><orcidid>https://orcid.org/0000-0002-6613-519X</orcidid><orcidid>https://orcid.org/0000-0002-2984-5512</orcidid><orcidid>https://orcid.org/0000-0002-0026-3391</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-2404 |
| ispartof | European heart journal cardiovascular imaging, 2024-08, Vol.25 (9), p.1276-1286 |
| issn | 2047-2404 2047-2412 2047-2412 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3050173789 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Aged, 80 and over Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery Echocardiography Female Heart Valve Prosthesis Implantation - adverse effects Heart Valve Prosthesis Implantation - methods Humans Male Registries Risk Assessment Stroke Volume - physiology Systole Transcatheter Aortic Valve Replacement - adverse effects Transcatheter Aortic Valve Replacement - methods Treatment Outcome Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry |
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