The common variable immunodeficiency IgM repertoire narrowly recognizes erythrocyte and platelet glycans

Autoimmune cytopenias (AICs) regularly occur in profoundly IgG-deficient patients with common variable immunodeficiency (CVID). The isotypes, antigenic targets, and origin(s) of their disease-causing autoantibodies are unclear. We sought to determine reactivity, clonality, and provenance of AIC-asso...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2024-09, Vol.154 (3), p.778-791.e9
Hauptverfasser:	Le Coz, Carole, Trofa, Melissa, Butler, Dorothy L., Yoon, Samuel, Tian, Tian, Reid, Whitney, Cruz Cabrera, Emylette, Knox, Ainsley V.C., Khanna, Caroline, Sullivan, Kathleen E., Heimall, Jennifer, Takach, Patricia, Fadugba, Olajumoke O., Lawrence, Monica, Jyonouchi, Soma, Hakonarson, Hakon, Wells, Andrew D., Handler, Steven, Zur, Karen B., Pillai, Vinodh, Gildersleeve, Jeffrey C., Romberg, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	autoantibodies autoimmune cytopenias Common variable immune deficiency glycans i antigen marginal zone B cell
Online-Zugang:	Volltext
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