Fenamates and ibuprofen as foundational components in the synthesis of innovative, targeted COX-2 anti-inflammatory drugs, undergoing thorough biopharmacological assessments and in-silico computational studies

[Display omitted] •Fenamates and ibuprofen were used for synthesis of novel anti- inflammatory drugs.•7b, c and 12a, b showed potent selective COX-2 inhibition in contrast to reference drugs.•7c exhibited potent in vivo activity by reducing the thickness of paw swelling.•7c demonstrated promising an...

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