Reduced sympathetic activity is associated with the development of pain and muscle atrophy in a female rat model of fibromyalgia

•Plasma epinephrine is decreased in priming models of fibromyalgia-like pain.•Clenbuterol attenuates hyperalgesia in an acid saline-induced fibromyalgia-like pain model.•Clenbuterol mitigates muscle atrophy in fibromyalgia priming model. Fibromyalgia (FM) is characterized by chronic widespread muscu...

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Veröffentlicht in:	Physiology & behavior 2024-07, Vol.281, p.114575-114575, Article 114575
Hauptverfasser:	da Silva, Raquel Prado, Costa, Daniely Messias, da Cruz-Filho, João, Santos, Tatiane de Oliveira, dos Anjos-Santos, Hevely Catharine, Vasconcelos, Alan Bruno Silva, Heck, Lilian Carmo, Kettelhut, Ísis do Carmo, Navegantes, Luiz Carlos, dos Santos, José Ronaldo, de Souza, Patrícia Rodrigues Marques, Badauê-Passos Jr, Daniel, Mecawi, André Souza, DeSantana, Josimari Melo, Lustrino, Danilo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Animals Carrageenan - toxicity Catecholamines - metabolism Clenbuterol - pharmacology Disease Models, Animal Epinephrine Female Fibromyalgia Fibromyalgia - pathology Fibromyalgia - physiopathology Hyperalgesia Hyperalgesia - pathology Hyperalgesia - physiopathology Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscular Atrophy - pathology Muscular Atrophy - physiopathology Pain - pathology Pain - physiopathology Proteolysis Rats Rats, Sprague-Dawley Skeletal muscle Sympathetic nervous system Sympathetic Nervous System - drug effects Sympathetic Nervous System - pathology Sympathetic Nervous System - physiopathology
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