Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of the mechanisms underlying AAA development and progression. ATF3 (activating transcription factor 3) has been increasingly recognized as a key regulator of cardiovascula...

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Veröffentlicht in:	Circulation research 2024-05, Vol.134 (11), p.1495-1511
Hauptverfasser:	Wen, Ying, Liu, Yingying, Li, Qiang, Tan, Jinlin, Fu, Xing, Liang, Yiwen, Tuo, Yonghua, Liu, Luhao, Zhou, Xueqiong, LiuFu, Dongkai, Fan, Xuejiao, Chen, Chaofei, Chen, Zheng, Wang, Zhouping, Fan, Shunyang, Liu, Renjing, Pan, Lei, Zhang, Yuan, Tang, Wai Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Angiotensin II Animals Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Apoptosis Cell Proliferation Cells, Cultured Disease Models, Animal Humans Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology
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