Thermoresponsive Core-cross-linked Nanoparticles from HA‑b‑ELP Diblock Copolymers

Stabilization against the dilution-dependent disassembly of self-assembled nanoparticles is a requirement for in vivo application. Herein, we propose a simple and biocompatible cross-linking reaction for the stabilization of a series of nanoparticles formed by the self-assembly of amphiphilic HA-b-E...

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Veröffentlicht in:	Biomacromolecules 2024-05, Vol.25 (5), p.3011-3017
Hauptverfasser:	Levêque, Manon, Lecommandoux, Sébastien, Garanger, Elisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	alkylation composite polymers Cross-Linking Reagents - chemistry crosslinking Elastin - chemistry hydrodynamics methionine nanoparticles Nanoparticles - chemistry Particle Size Polymers - chemistry Temperature
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container_end_page	3017
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container_title	Biomacromolecules
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creator	Levêque, Manon Lecommandoux, Sébastien Garanger, Elisabeth
description	Stabilization against the dilution-dependent disassembly of self-assembled nanoparticles is a requirement for in vivo application. Herein, we propose a simple and biocompatible cross-linking reaction for the stabilization of a series of nanoparticles formed by the self-assembly of amphiphilic HA-b-ELP block copolymers, through the alkylation of methionine residues from the ELP block with diglycidyl ether compounds. The core-cross-linked nanoparticles retain their colloidal properties, with a spherical core–shell morphology, while maintaining thermoresponsive behavior. As such, instead of a reversible disassembly when non-cross-linked, a reversible swelling of nanoparticles’ core and increase of hydrodynamic diameter are observed with lowering of the temperature.
doi_str_mv	10.1021/acs.biomac.4c00137
format	Article
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subjects	alkylation composite polymers Cross-Linking Reagents - chemistry crosslinking Elastin - chemistry hydrodynamics methionine nanoparticles Nanoparticles - chemistry Particle Size Polymers - chemistry Temperature
title	Thermoresponsive Core-cross-linked Nanoparticles from HA‑b‑ELP Diblock Copolymers
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