Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco)
In the context of investigations into molecules of natural origin with biological activities. This study focuses on the development of Myrtus communis L., a medicinal plant found in the mountains of Morocco. The first, an analysis carried out on leaves using the inductively coupled plasma spectromet...
Gespeichert in:
| Veröffentlicht in: | Chemistry & biodiversity 2024-06, Vol.21 (6), p.e202302114-n/a |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 6 |
| container_start_page | e202302114 |
| container_title | Chemistry & biodiversity |
| container_volume | 21 |
| creator | Hayani, Mouhcine Benabbouha, Tariq Naceiri Mrabti, Nidal Eljebri, Said Sabiri, Maryame Zair, Touriya |
| description | In the context of investigations into molecules of natural origin with biological activities. This study focuses on the development of Myrtus communis L., a medicinal plant found in the mountains of Morocco. The first, an analysis carried out on leaves using the inductively coupled plasma spectrometry technique, showed the almost total absence of heavy metals. Furthermore, we aim to identify the chemical composition of its essential oils by gas chromatography‐mass spectrometry (GC/MS) analysis and assess its antibacterial efficacy in vitro and in silico. The average yield of essential oils was 0.9 %±0.06, and GC/MS analysis identified 35 constituents, with myrcene (27,38 %), limonene (16,51 %), α‐pinene (7,32 %) being the major compounds. Remarkably, the essential oils displayed considerable antibacterial activity against various tested bacteria, including Escherichia coli (0.7 μL/mL), Escherichia pseudocoloides (2.8 μl/ml), Escherichia vekanda (2.8 μl/ml). Molecular docking has contributed to our understanding of the mechanism of antibacterial action of the main compounds in this essential oil. |
| doi_str_mv | 10.1002/cbdv.202302114 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3049721175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3049721175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3284-bd1f68d656e469b9b705af6d10c059e304afabbdcef427416b77f00f119e27ac3</originalsourceid><addsrcrecordid>eNqFkc1PwyAYh4nR-H31aEi8aGIn0Bba46zzI9kyD-q1AQoG05YJ7cz-e2k2Z-LFE-TleZ-8vD8AzjAaYYTIjRTVckQQiRHBONkBh5hiEuEsQ7vbOyMH4Mj7j8CHerYPDuKMZpSx9BC4W2O57MxSwWdntalN-34Nx21nRCgrZ3gNJ1obyeUK8raChW0Wfcc7Y9vwNLOVqoceaDWcrVzX-4Fo-tZ4OPFeBVHA5qaGlzPrrJT26gTsaV57dbo5j8Hr_eSleIym84enYjyNZEyyJBIV1jSraEpVQnORC4ZSrmmFkURprmKUcM2FqKTSCWEJpoIxjZDGOFeEcRkfg8u1d-HsZ698VzbGyzAub5XtfRkMOQtbY2lAL_6gH7Z34YMDRXOck5TFgRqtKems907pcuFMw92qxKgc0iiHNMptGqHhfKPtRaOqLf6z_gDka-DL1Gr1j64sbu_efuXfVAKWzA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3069192573</pqid></control><display><type>article</type><title>Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco)</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Hayani, Mouhcine ; Benabbouha, Tariq ; Naceiri Mrabti, Nidal ; Eljebri, Said ; Sabiri, Maryame ; Zair, Touriya</creator><creatorcontrib>Hayani, Mouhcine ; Benabbouha, Tariq ; Naceiri Mrabti, Nidal ; Eljebri, Said ; Sabiri, Maryame ; Zair, Touriya</creatorcontrib><description>In the context of investigations into molecules of natural origin with biological activities. This study focuses on the development of Myrtus communis L., a medicinal plant found in the mountains of Morocco. The first, an analysis carried out on leaves using the inductively coupled plasma spectrometry technique, showed the almost total absence of heavy metals. Furthermore, we aim to identify the chemical composition of its essential oils by gas chromatography‐mass spectrometry (GC/MS) analysis and assess its antibacterial efficacy in vitro and in silico. The average yield of essential oils was 0.9 %±0.06, and GC/MS analysis identified 35 constituents, with myrcene (27,38 %), limonene (16,51 %), α‐pinene (7,32 %) being the major compounds. Remarkably, the essential oils displayed considerable antibacterial activity against various tested bacteria, including Escherichia coli (0.7 μL/mL), Escherichia pseudocoloides (2.8 μl/ml), Escherichia vekanda (2.8 μl/ml). Molecular docking has contributed to our understanding of the mechanism of antibacterial action of the main compounds in this essential oil.</description><identifier>ISSN: 1612-1872</identifier><identifier>ISSN: 1612-1880</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202302114</identifier><identifier>PMID: 38686775</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antiinfectives and antibacterials ; Chemical composition ; Coliforms ; E coli ; Effectiveness ; Escherichia coli - drug effects ; Essential oils ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; GC/MS ; Heavy metals ; Herbal medicine ; Inductively coupled plasma ; Limonene ; Mass spectrometry ; Mass spectroscopy ; Medicinal plants ; Microbial Sensitivity Tests ; Molecular docking ; Molecular Docking Simulation ; Morocco ; Mountains ; Myrcene ; Myrtus - chemistry ; Myrtus communis L ; Oils, Volatile - chemistry ; Oils, Volatile - isolation & purification ; Oils, Volatile - pharmacology ; Phytochemistry ; Plant Leaves - chemistry ; quality control</subject><ispartof>Chemistry & biodiversity, 2024-06, Vol.21 (6), p.e202302114-n/a</ispartof><rights>2024 Wiley-VHCA AG, Zurich, Switzerland</rights><rights>2024 Wiley-VHCA AG, Zurich, Switzerland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3284-bd1f68d656e469b9b705af6d10c059e304afabbdcef427416b77f00f119e27ac3</cites><orcidid>0000-0001-7879-8073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202302114$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202302114$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38686775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayani, Mouhcine</creatorcontrib><creatorcontrib>Benabbouha, Tariq</creatorcontrib><creatorcontrib>Naceiri Mrabti, Nidal</creatorcontrib><creatorcontrib>Eljebri, Said</creatorcontrib><creatorcontrib>Sabiri, Maryame</creatorcontrib><creatorcontrib>Zair, Touriya</creatorcontrib><title>Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco)</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>In the context of investigations into molecules of natural origin with biological activities. This study focuses on the development of Myrtus communis L., a medicinal plant found in the mountains of Morocco. The first, an analysis carried out on leaves using the inductively coupled plasma spectrometry technique, showed the almost total absence of heavy metals. Furthermore, we aim to identify the chemical composition of its essential oils by gas chromatography‐mass spectrometry (GC/MS) analysis and assess its antibacterial efficacy in vitro and in silico. The average yield of essential oils was 0.9 %±0.06, and GC/MS analysis identified 35 constituents, with myrcene (27,38 %), limonene (16,51 %), α‐pinene (7,32 %) being the major compounds. Remarkably, the essential oils displayed considerable antibacterial activity against various tested bacteria, including Escherichia coli (0.7 μL/mL), Escherichia pseudocoloides (2.8 μl/ml), Escherichia vekanda (2.8 μl/ml). Molecular docking has contributed to our understanding of the mechanism of antibacterial action of the main compounds in this essential oil.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antiinfectives and antibacterials</subject><subject>Chemical composition</subject><subject>Coliforms</subject><subject>E coli</subject><subject>Effectiveness</subject><subject>Escherichia coli - drug effects</subject><subject>Essential oils</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>GC/MS</subject><subject>Heavy metals</subject><subject>Herbal medicine</subject><subject>Inductively coupled plasma</subject><subject>Limonene</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicinal plants</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular docking</subject><subject>Molecular Docking Simulation</subject><subject>Morocco</subject><subject>Mountains</subject><subject>Myrcene</subject><subject>Myrtus - chemistry</subject><subject>Myrtus communis L</subject><subject>Oils, Volatile - chemistry</subject><subject>Oils, Volatile - isolation & purification</subject><subject>Oils, Volatile - pharmacology</subject><subject>Phytochemistry</subject><subject>Plant Leaves - chemistry</subject><subject>quality control</subject><issn>1612-1872</issn><issn>1612-1880</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1PwyAYh4nR-H31aEi8aGIn0Bba46zzI9kyD-q1AQoG05YJ7cz-e2k2Z-LFE-TleZ-8vD8AzjAaYYTIjRTVckQQiRHBONkBh5hiEuEsQ7vbOyMH4Mj7j8CHerYPDuKMZpSx9BC4W2O57MxSwWdntalN-34Nx21nRCgrZ3gNJ1obyeUK8raChW0Wfcc7Y9vwNLOVqoceaDWcrVzX-4Fo-tZ4OPFeBVHA5qaGlzPrrJT26gTsaV57dbo5j8Hr_eSleIym84enYjyNZEyyJBIV1jSraEpVQnORC4ZSrmmFkURprmKUcM2FqKTSCWEJpoIxjZDGOFeEcRkfg8u1d-HsZ698VzbGyzAub5XtfRkMOQtbY2lAL_6gH7Z34YMDRXOck5TFgRqtKems907pcuFMw92qxKgc0iiHNMptGqHhfKPtRaOqLf6z_gDka-DL1Gr1j64sbu_efuXfVAKWzA</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Hayani, Mouhcine</creator><creator>Benabbouha, Tariq</creator><creator>Naceiri Mrabti, Nidal</creator><creator>Eljebri, Said</creator><creator>Sabiri, Maryame</creator><creator>Zair, Touriya</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7879-8073</orcidid></search><sort><creationdate>202406</creationdate><title>Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco)</title><author>Hayani, Mouhcine ; Benabbouha, Tariq ; Naceiri Mrabti, Nidal ; Eljebri, Said ; Sabiri, Maryame ; Zair, Touriya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3284-bd1f68d656e469b9b705af6d10c059e304afabbdcef427416b77f00f119e27ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antiinfectives and antibacterials</topic><topic>Chemical composition</topic><topic>Coliforms</topic><topic>E coli</topic><topic>Effectiveness</topic><topic>Escherichia coli - drug effects</topic><topic>Essential oils</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>GC/MS</topic><topic>Heavy metals</topic><topic>Herbal medicine</topic><topic>Inductively coupled plasma</topic><topic>Limonene</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicinal plants</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular docking</topic><topic>Molecular Docking Simulation</topic><topic>Morocco</topic><topic>Mountains</topic><topic>Myrcene</topic><topic>Myrtus - chemistry</topic><topic>Myrtus communis L</topic><topic>Oils, Volatile - chemistry</topic><topic>Oils, Volatile - isolation & purification</topic><topic>Oils, Volatile - pharmacology</topic><topic>Phytochemistry</topic><topic>Plant Leaves - chemistry</topic><topic>quality control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayani, Mouhcine</creatorcontrib><creatorcontrib>Benabbouha, Tariq</creatorcontrib><creatorcontrib>Naceiri Mrabti, Nidal</creatorcontrib><creatorcontrib>Eljebri, Said</creatorcontrib><creatorcontrib>Sabiri, Maryame</creatorcontrib><creatorcontrib>Zair, Touriya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayani, Mouhcine</au><au>Benabbouha, Tariq</au><au>Naceiri Mrabti, Nidal</au><au>Eljebri, Said</au><au>Sabiri, Maryame</au><au>Zair, Touriya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco)</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2024-06</date><risdate>2024</risdate><volume>21</volume><issue>6</issue><spage>e202302114</spage><epage>n/a</epage><pages>e202302114-n/a</pages><issn>1612-1872</issn><issn>1612-1880</issn><eissn>1612-1880</eissn><abstract>In the context of investigations into molecules of natural origin with biological activities. This study focuses on the development of Myrtus communis L., a medicinal plant found in the mountains of Morocco. The first, an analysis carried out on leaves using the inductively coupled plasma spectrometry technique, showed the almost total absence of heavy metals. Furthermore, we aim to identify the chemical composition of its essential oils by gas chromatography‐mass spectrometry (GC/MS) analysis and assess its antibacterial efficacy in vitro and in silico. The average yield of essential oils was 0.9 %±0.06, and GC/MS analysis identified 35 constituents, with myrcene (27,38 %), limonene (16,51 %), α‐pinene (7,32 %) being the major compounds. Remarkably, the essential oils displayed considerable antibacterial activity against various tested bacteria, including Escherichia coli (0.7 μL/mL), Escherichia pseudocoloides (2.8 μl/ml), Escherichia vekanda (2.8 μl/ml). Molecular docking has contributed to our understanding of the mechanism of antibacterial action of the main compounds in this essential oil.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38686775</pmid><doi>10.1002/cbdv.202302114</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7879-8073</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1612-1872 |
| ispartof | Chemistry & biodiversity, 2024-06, Vol.21 (6), p.e202302114-n/a |
| issn | 1612-1872 1612-1880 1612-1880 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3049721175 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial activity Antiinfectives and antibacterials Chemical composition Coliforms E coli Effectiveness Escherichia coli - drug effects Essential oils Gas chromatography Gas Chromatography-Mass Spectrometry GC/MS Heavy metals Herbal medicine Inductively coupled plasma Limonene Mass spectrometry Mass spectroscopy Medicinal plants Microbial Sensitivity Tests Molecular docking Molecular Docking Simulation Morocco Mountains Myrcene Myrtus - chemistry Myrtus communis L Oils, Volatile - chemistry Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Phytochemistry Plant Leaves - chemistry quality control |
| title | Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T09%3A01%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioactive%20Profiling,%20Antibacterial%20Efficacy%20and%20Computational%20Modelling%20of%20Myrtus%20Communis%20Essential%20Oil%20(Morocco)&rft.jtitle=Chemistry%20&%20biodiversity&rft.au=Hayani,%20Mouhcine&rft.date=2024-06&rft.volume=21&rft.issue=6&rft.spage=e202302114&rft.epage=n/a&rft.pages=e202302114-n/a&rft.issn=1612-1872&rft.eissn=1612-1880&rft_id=info:doi/10.1002/cbdv.202302114&rft_dat=%3Cproquest_cross%3E3049721175%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3069192573&rft_id=info:pmid/38686775&rfr_iscdi=true |