A novel class of insecticidal alkylsulfones are potent inhibitors of vesicular acetylcholine transport

Pyridine alkylsulfone derivatives typified by oxazosulfyl (Sumitomo Chemical Company Ltd.) and compound A2 (Syngenta) represent a new class of insecticides, with potent activity against several insect orders. Whilst the MOA of this class has been attributed to interaction with the voltage-gated sodi...

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Veröffentlicht in:	Pesticide biochemistry and physiology 2024-05, Vol.201, p.105854-105854, Article 105854
Hauptverfasser:	Goodchild, James, Chen, Ying-Ju, Blythe, Judith, Firth, Lucy C., Hirst, Elizabeth, Bess, Kirsty, Bristow, Julia, Willis, Jenny, Baines, Richard, Cash, Francesca, Muehlebach, Michel, Buchholz, Anke, Rendler, Sebastian, Earley, Fergus, Crossthwaite, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Alkylsulfone insecticide Animals Cholinergic transmission Drosophila Insecticides - chemistry Insecticides - pharmacology Miniature EPSCs Mode of action (MOA) Neurotoxicology Periplaneta - drug effects Periplaneta - metabolism Sulfones - chemistry Sulfones - pharmacology Synaptic Transmission - drug effects Vesicular acetylcholine transporter (VAChT)
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