AXL receptor as an emerging molecular target in colorectal cancer

•Several lines of preclinical evidence link the AXL/GAS6 protein system to colorectal cancer.•Axl overexpression is a negative prognostic factor in colorectal cancer.•Drugs inhibiting the Axl receptor are under clinical evaluation for colorectal cancer.•Molecules targeting the Axl receptor could exp...

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Veröffentlicht in:	Drug discovery today 2024-06, Vol.29 (6), p.104005-104005, Article 104005
Hauptverfasser:	De Rosa, Lucia, Di Stasi, Rossella, Fusco, Virginia, D'Andrea, Luca D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Axl Receptor Tyrosine Kinase Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Humans Molecular Targeted Therapy Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism
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