Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China
Aim To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China. Methods This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Cont...
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Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2024-07, Vol.26 (7), p.2869-2880 |
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creator | Su, Jian Fan, Xikang Li, Mengyao Yu, Hao Geng, Houyue Qin, Yu Lu, Yan Pei, Pei Sun, Dianjianyi Yu, Canqing Lv, Jun Tao, Ran Zhou, Jinyi Ma, Hongxia Wu, Ming |
description | Aim
To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China.
Methods
This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models.
Results
During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH.
Conclusions
Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes. |
doi_str_mv | 10.1111/dom.15606 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3049718582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3049718582</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3206-21392e9457310d8ad97bae5c56be76cefa636b3c2650ff44e0d46ba1ec3aa6b63</originalsourceid><addsrcrecordid>eNp1kL9OwzAQhy0EoqUw8ALIIwxp7dhxEraq_JWKupQ5cuyLaprWJU5adevKa_IkuE1h45a74btPdz-ErinpU18DbRd9GgkiTlCXcsECykJxepjDIElJ2EEXzn0QQjhL4nPUYYlIPE-7aDd0zioja2OX2Ba4NAW4elsC3ph6hivQjQKNXV3ZOeDKuDk2S8zp9-6LUe5nbdZGN7J07YI2Moca3D2ebixeVdatQNVmDVjZma1qb2q0Abe3jGZmKS_RWeG34erYe-j96XE6egnGk-fX0XAcKBYSEYSUpSGkPIoZJTqROo1zCZGKRA6xUFBIwUTOVCgiUhScA9Fc5JKCYlKKXLAeum29_qbPxv-YLYxTUJZyCbZxGSM8jWkSJaFH71pU-fNdBUW2qsxCVtuMkmwfeOYDzw6Be_bmqG3yBeg_8jdhDwxaYGNK2P5vyh4mb63yB_27jJU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3049718582</pqid></control><display><type>article</type><title>Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Su, Jian ; Fan, Xikang ; Li, Mengyao ; Yu, Hao ; Geng, Houyue ; Qin, Yu ; Lu, Yan ; Pei, Pei ; Sun, Dianjianyi ; Yu, Canqing ; Lv, Jun ; Tao, Ran ; Zhou, Jinyi ; Ma, Hongxia ; Wu, Ming</creator><creatorcontrib>Su, Jian ; Fan, Xikang ; Li, Mengyao ; Yu, Hao ; Geng, Houyue ; Qin, Yu ; Lu, Yan ; Pei, Pei ; Sun, Dianjianyi ; Yu, Canqing ; Lv, Jun ; Tao, Ran ; Zhou, Jinyi ; Ma, Hongxia ; Wu, Ming</creatorcontrib><description>Aim
To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China.
Methods
This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models.
Results
During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH.
Conclusions
Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.15606</identifier><identifier>PMID: 38685601</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Cerebral Hemorrhage - epidemiology ; China - epidemiology ; Cohort Studies ; diabetes ; Diabetes Mellitus - epidemiology ; Exercise ; Female ; Healthy Lifestyle ; Humans ; Life Style ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; stroke ; Stroke - epidemiology ; Stroke - etiology ; Stroke - prevention & control</subject><ispartof>Diabetes, obesity & metabolism, 2024-07, Vol.26 (7), p.2869-2880</ispartof><rights>2024 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3206-21392e9457310d8ad97bae5c56be76cefa636b3c2650ff44e0d46ba1ec3aa6b63</cites><orcidid>0000-0001-6057-862X ; 0000-0002-9944-284X ; 0000-0001-7916-3870 ; 0000-0003-3651-6693 ; 0000-0002-6072-5578 ; 0000-0002-8798-0288 ; 0000-0002-4026-4823 ; 0000-0002-0019-0014 ; 0000-0002-9821-6955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.15606$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.15606$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38685601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Jian</creatorcontrib><creatorcontrib>Fan, Xikang</creatorcontrib><creatorcontrib>Li, Mengyao</creatorcontrib><creatorcontrib>Yu, Hao</creatorcontrib><creatorcontrib>Geng, Houyue</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Pei, Pei</creatorcontrib><creatorcontrib>Sun, Dianjianyi</creatorcontrib><creatorcontrib>Yu, Canqing</creatorcontrib><creatorcontrib>Lv, Jun</creatorcontrib><creatorcontrib>Tao, Ran</creatorcontrib><creatorcontrib>Zhou, Jinyi</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><title>Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aim
To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China.
Methods
This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models.
Results
During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH.
Conclusions
Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>diabetes</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Exercise</subject><subject>Female</subject><subject>Healthy Lifestyle</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>stroke</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Stroke - prevention & control</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kL9OwzAQhy0EoqUw8ALIIwxp7dhxEraq_JWKupQ5cuyLaprWJU5adevKa_IkuE1h45a74btPdz-ErinpU18DbRd9GgkiTlCXcsECykJxepjDIElJ2EEXzn0QQjhL4nPUYYlIPE-7aDd0zioja2OX2Ba4NAW4elsC3ph6hivQjQKNXV3ZOeDKuDk2S8zp9-6LUe5nbdZGN7J07YI2Moca3D2ebixeVdatQNVmDVjZma1qb2q0Abe3jGZmKS_RWeG34erYe-j96XE6egnGk-fX0XAcKBYSEYSUpSGkPIoZJTqROo1zCZGKRA6xUFBIwUTOVCgiUhScA9Fc5JKCYlKKXLAeum29_qbPxv-YLYxTUJZyCbZxGSM8jWkSJaFH71pU-fNdBUW2qsxCVtuMkmwfeOYDzw6Be_bmqG3yBeg_8jdhDwxaYGNK2P5vyh4mb63yB_27jJU</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Su, Jian</creator><creator>Fan, Xikang</creator><creator>Li, Mengyao</creator><creator>Yu, Hao</creator><creator>Geng, Houyue</creator><creator>Qin, Yu</creator><creator>Lu, Yan</creator><creator>Pei, Pei</creator><creator>Sun, Dianjianyi</creator><creator>Yu, Canqing</creator><creator>Lv, Jun</creator><creator>Tao, Ran</creator><creator>Zhou, Jinyi</creator><creator>Ma, Hongxia</creator><creator>Wu, Ming</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6057-862X</orcidid><orcidid>https://orcid.org/0000-0002-9944-284X</orcidid><orcidid>https://orcid.org/0000-0001-7916-3870</orcidid><orcidid>https://orcid.org/0000-0003-3651-6693</orcidid><orcidid>https://orcid.org/0000-0002-6072-5578</orcidid><orcidid>https://orcid.org/0000-0002-8798-0288</orcidid><orcidid>https://orcid.org/0000-0002-4026-4823</orcidid><orcidid>https://orcid.org/0000-0002-0019-0014</orcidid><orcidid>https://orcid.org/0000-0002-9821-6955</orcidid></search><sort><creationdate>202407</creationdate><title>Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China</title><author>Su, Jian ; Fan, Xikang ; Li, Mengyao ; Yu, Hao ; Geng, Houyue ; Qin, Yu ; Lu, Yan ; Pei, Pei ; Sun, Dianjianyi ; Yu, Canqing ; Lv, Jun ; Tao, Ran ; Zhou, Jinyi ; Ma, Hongxia ; Wu, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3206-21392e9457310d8ad97bae5c56be76cefa636b3c2650ff44e0d46ba1ec3aa6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Cerebral Hemorrhage - epidemiology</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>diabetes</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Exercise</topic><topic>Female</topic><topic>Healthy Lifestyle</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>stroke</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Stroke - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Jian</creatorcontrib><creatorcontrib>Fan, Xikang</creatorcontrib><creatorcontrib>Li, Mengyao</creatorcontrib><creatorcontrib>Yu, Hao</creatorcontrib><creatorcontrib>Geng, Houyue</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Pei, Pei</creatorcontrib><creatorcontrib>Sun, Dianjianyi</creatorcontrib><creatorcontrib>Yu, Canqing</creatorcontrib><creatorcontrib>Lv, Jun</creatorcontrib><creatorcontrib>Tao, Ran</creatorcontrib><creatorcontrib>Zhou, Jinyi</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Jian</au><au>Fan, Xikang</au><au>Li, Mengyao</au><au>Yu, Hao</au><au>Geng, Houyue</au><au>Qin, Yu</au><au>Lu, Yan</au><au>Pei, Pei</au><au>Sun, Dianjianyi</au><au>Yu, Canqing</au><au>Lv, Jun</au><au>Tao, Ran</au><au>Zhou, Jinyi</au><au>Ma, Hongxia</au><au>Wu, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2024-07</date><risdate>2024</risdate><volume>26</volume><issue>7</issue><spage>2869</spage><epage>2880</epage><pages>2869-2880</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Aim
To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China.
Methods
This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models.
Results
During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH.
Conclusions
Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>38685601</pmid><doi>10.1111/dom.15606</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6057-862X</orcidid><orcidid>https://orcid.org/0000-0002-9944-284X</orcidid><orcidid>https://orcid.org/0000-0001-7916-3870</orcidid><orcidid>https://orcid.org/0000-0003-3651-6693</orcidid><orcidid>https://orcid.org/0000-0002-6072-5578</orcidid><orcidid>https://orcid.org/0000-0002-8798-0288</orcidid><orcidid>https://orcid.org/0000-0002-4026-4823</orcidid><orcidid>https://orcid.org/0000-0002-0019-0014</orcidid><orcidid>https://orcid.org/0000-0002-9821-6955</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Cerebral Hemorrhage - epidemiology China - epidemiology Cohort Studies diabetes Diabetes Mellitus - epidemiology Exercise Female Healthy Lifestyle Humans Life Style Male Middle Aged Proportional Hazards Models Prospective Studies Risk Factors stroke Stroke - epidemiology Stroke - etiology Stroke - prevention & control |
title | Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China |
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