Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China

Aim To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China. Methods This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Cont...

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Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2024-07, Vol.26 (7), p.2869-2880
Hauptverfasser: Su, Jian, Fan, Xikang, Li, Mengyao, Yu, Hao, Geng, Houyue, Qin, Yu, Lu, Yan, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Lv, Jun, Tao, Ran, Zhou, Jinyi, Ma, Hongxia, Wu, Ming
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container_end_page 2880
container_issue 7
container_start_page 2869
container_title Diabetes, obesity & metabolism
container_volume 26
creator Su, Jian
Fan, Xikang
Li, Mengyao
Yu, Hao
Geng, Houyue
Qin, Yu
Lu, Yan
Pei, Pei
Sun, Dianjianyi
Yu, Canqing
Lv, Jun
Tao, Ran
Zhou, Jinyi
Ma, Hongxia
Wu, Ming
description Aim To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China. Methods This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models. Results During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH. Conclusions Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.
doi_str_mv 10.1111/dom.15606
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Methods This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models. Results During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH. Conclusions Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.15606</identifier><identifier>PMID: 38685601</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Cerebral Hemorrhage - epidemiology ; China - epidemiology ; Cohort Studies ; diabetes ; Diabetes Mellitus - epidemiology ; Exercise ; Female ; Healthy Lifestyle ; Humans ; Life Style ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; stroke ; Stroke - epidemiology ; Stroke - etiology ; Stroke - prevention &amp; control</subject><ispartof>Diabetes, obesity &amp; metabolism, 2024-07, Vol.26 (7), p.2869-2880</ispartof><rights>2024 The Authors. published by John Wiley &amp; Sons Ltd.</rights><rights>2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3206-21392e9457310d8ad97bae5c56be76cefa636b3c2650ff44e0d46ba1ec3aa6b63</cites><orcidid>0000-0001-6057-862X ; 0000-0002-9944-284X ; 0000-0001-7916-3870 ; 0000-0003-3651-6693 ; 0000-0002-6072-5578 ; 0000-0002-8798-0288 ; 0000-0002-4026-4823 ; 0000-0002-0019-0014 ; 0000-0002-9821-6955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.15606$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.15606$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38685601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Jian</creatorcontrib><creatorcontrib>Fan, Xikang</creatorcontrib><creatorcontrib>Li, Mengyao</creatorcontrib><creatorcontrib>Yu, Hao</creatorcontrib><creatorcontrib>Geng, Houyue</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Pei, Pei</creatorcontrib><creatorcontrib>Sun, Dianjianyi</creatorcontrib><creatorcontrib>Yu, Canqing</creatorcontrib><creatorcontrib>Lv, Jun</creatorcontrib><creatorcontrib>Tao, Ran</creatorcontrib><creatorcontrib>Zhou, Jinyi</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><title>Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China</title><title>Diabetes, obesity &amp; metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aim To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China. Methods This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models. Results During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH. 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control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Jian</creatorcontrib><creatorcontrib>Fan, Xikang</creatorcontrib><creatorcontrib>Li, Mengyao</creatorcontrib><creatorcontrib>Yu, Hao</creatorcontrib><creatorcontrib>Geng, Houyue</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Pei, Pei</creatorcontrib><creatorcontrib>Sun, Dianjianyi</creatorcontrib><creatorcontrib>Yu, Canqing</creatorcontrib><creatorcontrib>Lv, Jun</creatorcontrib><creatorcontrib>Tao, Ran</creatorcontrib><creatorcontrib>Zhou, Jinyi</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity &amp; metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Jian</au><au>Fan, Xikang</au><au>Li, Mengyao</au><au>Yu, Hao</au><au>Geng, Houyue</au><au>Qin, Yu</au><au>Lu, Yan</au><au>Pei, Pei</au><au>Sun, Dianjianyi</au><au>Yu, Canqing</au><au>Lv, Jun</au><au>Tao, Ran</au><au>Zhou, Jinyi</au><au>Ma, Hongxia</au><au>Wu, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China</atitle><jtitle>Diabetes, obesity &amp; metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2024-07</date><risdate>2024</risdate><volume>26</volume><issue>7</issue><spage>2869</spage><epage>2880</epage><pages>2869-2880</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Aim To investigate the associations of individual and combined healthy lifestyle factors (HLS) with the risk of stroke in individuals with diabetes in China. Methods This prospective analysis included 41 314 individuals with diabetes [15 191 from the Comprehensive Research on the Prevention and Control of the Diabetes (CRPCD) project and 26 123 from the China Kadoorie Biobank (CKB) study]. Associations of lifestyle factors, including cigarette smoking, alcohol consumption, physical activity, diet, body shape and sleep duration, with the risk of stroke, intracerebral haemorrhage (ICH) and ischaemic stroke (IS) were assessed using Cox proportional hazard models. Results During median follow‐up periods of 8.02 and 9.05 years, 2499 and 4578 cases of stroke, 2147 and 4024 of IS, and 160 and 728 of ICH were documented in individuals with diabetes in the CRPCD and CKB cohorts, respectively. In the CRPCD cohort, patients with ≥5 HLS had a 14% lower risk of stroke (hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.75‐0.98) than those with ≤2 HLS. In the CKB cohort, the adjusted HR (95% CI) for patients with ≥5 HLS were 0.74 (0.66‐0.83) for stroke, 0.74 (0.66‐0.83) for IS, and 0.57 (0.42‐0.78) for ICH compared with those with ≤2 HLS. The pooled adjusted HR (95% CI) comparing patients with ≥5 HLS versus ≤2 HLS was 0.79 (0.69‐0.92) for stroke, 0.80 (0.68‐0.93) for IS, and 0.60 (0.46‐0.78) for ICH. Conclusions Maintaining a healthy lifestyle was associated with a lower risk of stroke, IS and ICH among individuals with diabetes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>38685601</pmid><doi>10.1111/dom.15606</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6057-862X</orcidid><orcidid>https://orcid.org/0000-0002-9944-284X</orcidid><orcidid>https://orcid.org/0000-0001-7916-3870</orcidid><orcidid>https://orcid.org/0000-0003-3651-6693</orcidid><orcidid>https://orcid.org/0000-0002-6072-5578</orcidid><orcidid>https://orcid.org/0000-0002-8798-0288</orcidid><orcidid>https://orcid.org/0000-0002-4026-4823</orcidid><orcidid>https://orcid.org/0000-0002-0019-0014</orcidid><orcidid>https://orcid.org/0000-0002-9821-6955</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adult
Aged
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Cerebral Hemorrhage - epidemiology
China - epidemiology
Cohort Studies
diabetes
Diabetes Mellitus - epidemiology
Exercise
Female
Healthy Lifestyle
Humans
Life Style
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
stroke
Stroke - epidemiology
Stroke - etiology
Stroke - prevention & control
title Association of lifestyle with reduced stroke risk in 41 314 individuals with diabetes: Two prospective cohort studies in China
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