H2AX: A key player in DNA damage response and a promising target for cancer therapy

Cancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA damage is not repaired, it c...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-06, Vol.175, p.116663, Article 116663
Hauptverfasser:	Prabhu, Kirti S., Kuttikrishnan, Shilpa, Ahmad, Nuha, Habeeba, Ummu, Mariyam, Zahwa, Suleman, Muhammad, Bhat, Ajaz A., Uddin, Shahab
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer therapy Cell cycle checkpoints DNA damage response DNA repair mechanisms Genomic stability H2AX phosphorylation
Online-Zugang:	Volltext
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