mmu‐miR‐185 regulates osteoclasts differentiation and migration by targeting Btk

Background Bones undergo a constant remodeling, a process involving osteoclast‐mediated bone resorption and osteoblast‐mediated bone formation, crucial for maintaining healthy bone mass. We previously observed that miR‐185 depletion may promote bone formation by regulating Bgn expression and the BMP...

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Veröffentlicht in:	The journal of gene medicine 2024-05, Vol.26 (5), p.e3687-n/a
Hauptverfasser:	He, Dan, Jiao, Yueying, Xu, Jian, Luo, Junjie, Cui, Yaqi, Han, Xiabing, Zhao, Hongshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase (tartrate-resistant) Agammaglobulinaemia Tyrosine Kinase - genetics Agammaglobulinaemia Tyrosine Kinase - metabolism Animals Bone growth Bone marrow Bone mass Bone remodeling Bone resorption Btk Cell differentiation Cell Differentiation - genetics Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Chromosome 5 Gene Expression Regulation Leukocyte migration Macrophages Macrophages - metabolism Mice Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism mmu‐miR‐185 Monocytes Osteoclastogenesis Osteoclasts Osteoclasts - cytology Osteoclasts - metabolism Osteogenesis Osteogenesis - genetics RNA-directed DNA polymerase Signal Transduction Smad protein
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