Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma
Intraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare ca...
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| Veröffentlicht in: | Malaysian journal of pathology 2024-04, Vol.46 (1), p.91-94 |
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| container_title | Malaysian journal of pathology |
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| creator | Lim, C C W Punjabi, L S Bhatia, A Ng, Q J Jevon, G P Aggarwal, I M |
| description | Intraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no maternal or neonatal metastasis, and maternal serum beta-hCG levels downtrended with conservative management. We aim to highlight the importance of performing a detailed physical examination and evaluation of the patient and multidisciplinary management with oncology opinion. A detailed examination of the placenta should also be considered when faced with obstetric complications so that early diagnosis and the required management can be executed in a prompt fashion. |
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It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no maternal or neonatal metastasis, and maternal serum beta-hCG levels downtrended with conservative management. We aim to highlight the importance of performing a detailed physical examination and evaluation of the patient and multidisciplinary management with oncology opinion. A detailed examination of the placenta should also be considered when faced with obstetric complications so that early diagnosis and the required management can be executed in a prompt fashion.</description><identifier>ISSN: 0126-8635</identifier><identifier>PMID: 38682848</identifier><language>eng</language><publisher>Malaysia: College of Pathologists, Academy of Medicine of Malaysia</publisher><subject>Abdomen ; Adult ; Anemia ; Ascites ; Case reports ; Chemotherapy ; Childbirth & labor ; Choriocarcinoma - diagnosis ; Choriocarcinoma - pathology ; Consent ; Female ; Hemorrhage ; Humans ; Literature reviews ; Metastasis ; Miscarriage ; Obstetrics ; Oncology ; Patients ; Placenta ; Pregnancy ; Pregnancy Complications, Neoplastic - diagnosis ; Pregnancy Complications, Neoplastic - pathology ; Surveillance ; Systematic review ; Tertiary Care Centers ; Uterine Neoplasms - diagnosis ; Uterine Neoplasms - pathology ; Vagina</subject><ispartof>Malaysian journal of pathology, 2024-04, Vol.46 (1), p.91-94</ispartof><rights>Copyright College of Pathologists, Academy of Medicine of Malaysia Apr 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38682848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, C C W</creatorcontrib><creatorcontrib>Punjabi, L S</creatorcontrib><creatorcontrib>Bhatia, A</creatorcontrib><creatorcontrib>Ng, Q J</creatorcontrib><creatorcontrib>Jevon, G P</creatorcontrib><creatorcontrib>Aggarwal, I M</creatorcontrib><title>Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma</title><title>Malaysian journal of pathology</title><addtitle>Malays J Pathol</addtitle><description>Intraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no maternal or neonatal metastasis, and maternal serum beta-hCG levels downtrended with conservative management. We aim to highlight the importance of performing a detailed physical examination and evaluation of the patient and multidisciplinary management with oncology opinion. A detailed examination of the placenta should also be considered when faced with obstetric complications so that early diagnosis and the required management can be executed in a prompt fashion.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Anemia</subject><subject>Ascites</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Childbirth & labor</subject><subject>Choriocarcinoma - diagnosis</subject><subject>Choriocarcinoma - pathology</subject><subject>Consent</subject><subject>Female</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Metastasis</subject><subject>Miscarriage</subject><subject>Obstetrics</subject><subject>Oncology</subject><subject>Patients</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic - diagnosis</subject><subject>Pregnancy Complications, Neoplastic - pathology</subject><subject>Surveillance</subject><subject>Systematic review</subject><subject>Tertiary Care Centers</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - pathology</subject><subject>Vagina</subject><issn>0126-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0M1KxDAUBeAuFGccfQUJuHFTSJsmTZcy-AeDbnRdbpPbmQxtUpPU0Y3PbovjxtWFw8fhck6SJc1ykUrB-CI5D2FPqSiqSp4lCyaFzGUhl8n3M3yYLURjtwQsGS1-DqgiaqINbK0LJpCUzKE3aBUS1xIgEX004L-Ixxa9h44otNEjOZi4I_HgiIKAYcZmymHoYAaz2zlvnAKvjHU9XCSnLXQBL493lbzd372uH9PNy8PT-naTDjmrYip0zitsGYLMGUXNOC2xUDlvirJF2nAoOeRKykxUKLWmhYZG0CaTSvBMc7ZKbn57B-_eRwyx7k1Q2HVg0Y2hZrSQpZDVNNYquf5H9270dvpuUpzNriwmdXVUY9Ojrgdv-mmQ-m9Z9gM--nXh</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Lim, C C W</creator><creator>Punjabi, L S</creator><creator>Bhatia, A</creator><creator>Ng, Q J</creator><creator>Jevon, G P</creator><creator>Aggarwal, I M</creator><general>College of Pathologists, Academy of Medicine of Malaysia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202404</creationdate><title>Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma</title><author>Lim, C C W ; Punjabi, L S ; Bhatia, A ; Ng, Q J ; Jevon, G P ; Aggarwal, I M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-6d259ef3ea8230ed3507e4c25b47fe0b5a75a2c88169e8dd04dab60b18c651d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Anemia</topic><topic>Ascites</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Childbirth & labor</topic><topic>Choriocarcinoma - diagnosis</topic><topic>Choriocarcinoma - pathology</topic><topic>Consent</topic><topic>Female</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Metastasis</topic><topic>Miscarriage</topic><topic>Obstetrics</topic><topic>Oncology</topic><topic>Patients</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Neoplastic - diagnosis</topic><topic>Pregnancy Complications, Neoplastic - pathology</topic><topic>Surveillance</topic><topic>Systematic review</topic><topic>Tertiary Care Centers</topic><topic>Uterine Neoplasms - diagnosis</topic><topic>Uterine Neoplasms - pathology</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, C C W</creatorcontrib><creatorcontrib>Punjabi, L S</creatorcontrib><creatorcontrib>Bhatia, A</creatorcontrib><creatorcontrib>Ng, Q J</creatorcontrib><creatorcontrib>Jevon, G P</creatorcontrib><creatorcontrib>Aggarwal, I M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Malaysian journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, C C W</au><au>Punjabi, L S</au><au>Bhatia, A</au><au>Ng, Q J</au><au>Jevon, G P</au><au>Aggarwal, I M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma</atitle><jtitle>Malaysian journal of pathology</jtitle><addtitle>Malays J Pathol</addtitle><date>2024-04</date><risdate>2024</risdate><volume>46</volume><issue>1</issue><spage>91</spage><epage>94</epage><pages>91-94</pages><issn>0126-8635</issn><abstract>Intraplacental choriocarcinoma is a rare tumour, with approximately 62 reported cases. It may manifest as a spectrum of disease ranging from an incidental lesion diagnosed on routine placental examination to disseminated maternal and/or neonatal disease. In this case series, we presented two rare cases of intraplacental choriocarcinoma with extremely varied clinical presentations. The extremely varied clinical presentations of both patients described in the case series complicated the process of arriving at the diagnosis. In both cases, subsequent investigations showed no maternal or neonatal metastasis, and maternal serum beta-hCG levels downtrended with conservative management. We aim to highlight the importance of performing a detailed physical examination and evaluation of the patient and multidisciplinary management with oncology opinion. 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| identifier | ISSN: 0126-8635 |
| ispartof | Malaysian journal of pathology, 2024-04, Vol.46 (1), p.91-94 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Abdomen Adult Anemia Ascites Case reports Chemotherapy Childbirth & labor Choriocarcinoma - diagnosis Choriocarcinoma - pathology Consent Female Hemorrhage Humans Literature reviews Metastasis Miscarriage Obstetrics Oncology Patients Placenta Pregnancy Pregnancy Complications, Neoplastic - diagnosis Pregnancy Complications, Neoplastic - pathology Surveillance Systematic review Tertiary Care Centers Uterine Neoplasms - diagnosis Uterine Neoplasms - pathology Vagina |
| title | Navigating an unexpected diagnosis - experience of a tertiary referral centre with two cases of intraplacental choriocarcinoma |
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