PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining feature of PAH is the inappropriate remodeling of pulmonary arteries (PA) leading to right ventricle failure and death. Although treatment of PAH...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2024-07, Vol.150 (5), p.393-410
Hauptverfasser:	Bordan, Zsuzsanna, Batori, Robert K, Haigh, Stephen, Li, Xueyi, Meadows, Mary Louise, Brown, Zach L, West, Madison A, Dong, Kunzhe, Han, Weihong, Su, Yunchao, Ma, Qian, Huo, Yuqing, Zhou, Jiliang, Abdelbary, Mahmoud, Sullivan, Jennifer C, Weintraub, Neal L, Stepp, David W, Chen, Feng, Barman, Scott A, Fulton, David J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Disease Models, Animal Humans Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase Kinases Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Pulmonary Arterial Hypertension - genetics Pulmonary Arterial Hypertension - metabolism Pulmonary Arterial Hypertension - pathology Pulmonary Arterial Hypertension - physiopathology Pulmonary Artery - metabolism Pulmonary Artery - pathology Pulmonary Artery - physiopathology Rats Rats, Sprague-Dawley Vascular Remodeling
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