Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study
Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome instability. PM exposure is a major health concern worldwide, but its effects with genetic factors on mLOY has never been investigated. Here we explored the associations of PM2.5 and PM10 exp...
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| creator | Guan, Xin Meng, Xia Zhong, Guorong Zhang, Zirui Wang, Chenming Xiao, Yang Fu, Ming Zhao, Hui Zhou, Yuhan Hong, Shiru Xu, Xuedan Bai, Yansen Kan, Haidong Chen, Renjie Wu, Tangchun Guo, Huan |
| description | Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome instability. PM exposure is a major health concern worldwide, but its effects with genetic factors on mLOY has never been investigated. Here we explored the associations of PM2.5 and PM10 exposure with mLOY of 10,158 males measured via signal intensity of 2186 probes in male-specific chromosome-Y region from Illumina array data. The interactive and joint effects of PM2.5 and PM10 with genetic factors and smoking on mLOY were further evaluated. Compared with the lowest tertiles of PM2.5 levels in each exposure window, the highest tertiles in the same day, 7-, 14-, 21-, and 28-day showed a 0.005, 0.006, 0.007, 0.007, and 0.006 decrease in mLRR-Y, respectively (all P |
| doi_str_mv | 10.1016/j.jhazmat.2024.134315 |
| format | Article |
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[Display omitted]
●Effects of PM pollution and genetic factors on mLOY remain largely unknown.●High exposure to PM2.5 and PM10 were associated with elevated mLOY.●rs1122138, rs12448386, and rs56087422 can modified the PM-mLOY associations.●PM exposure with PRS and smoking take joint effects on mLOY.</description><identifier>ISSN: 0304-3894</identifier><identifier>ISSN: 1873-3336</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2024.134315</identifier><identifier>PMID: 38678703</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Air Pollutants - toxicity ; Air Pollution - adverse effects ; China ; Chromosomes, Human, Y ; Cohort Studies ; Environmental Exposure - adverse effects ; Genetic Risk Score ; Humans ; Male ; Male population ; Middle Aged ; Mosaic loss of chromosome Y ; Mosaicism ; Particulate Matter - toxicity ; PM10 ; PM2.5 ; Polygenic risk score ; Risk Factors ; Smoking</subject><ispartof>Journal of hazardous materials, 2024-06, Vol.471, p.134315, Article 134315</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c313t-db43b2c53d1ea0bd90961d0cee5e00cfd4745b0a622b0eedc1ec41b4d5fe9a1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030438942400894X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38678703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guan, Xin</creatorcontrib><creatorcontrib>Meng, Xia</creatorcontrib><creatorcontrib>Zhong, Guorong</creatorcontrib><creatorcontrib>Zhang, Zirui</creatorcontrib><creatorcontrib>Wang, Chenming</creatorcontrib><creatorcontrib>Xiao, Yang</creatorcontrib><creatorcontrib>Fu, Ming</creatorcontrib><creatorcontrib>Zhao, Hui</creatorcontrib><creatorcontrib>Zhou, Yuhan</creatorcontrib><creatorcontrib>Hong, Shiru</creatorcontrib><creatorcontrib>Xu, Xuedan</creatorcontrib><creatorcontrib>Bai, Yansen</creatorcontrib><creatorcontrib>Kan, Haidong</creatorcontrib><creatorcontrib>Chen, Renjie</creatorcontrib><creatorcontrib>Wu, Tangchun</creatorcontrib><creatorcontrib>Guo, Huan</creatorcontrib><title>Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome instability. PM exposure is a major health concern worldwide, but its effects with genetic factors on mLOY has never been investigated. Here we explored the associations of PM2.5 and PM10 exposure with mLOY of 10,158 males measured via signal intensity of 2186 probes in male-specific chromosome-Y region from Illumina array data. The interactive and joint effects of PM2.5 and PM10 with genetic factors and smoking on mLOY were further evaluated. Compared with the lowest tertiles of PM2.5 levels in each exposure window, the highest tertiles in the same day, 7-, 14-, 21-, and 28-day showed a 0.005, 0.006, 0.007, 0.007, and 0.006 decrease in mLRR-Y, respectively (all P < 0.05), with adjustment for age, BMI, smoking pack-years, alcohol drinking status, physical activity, education levels, season of blood draw, and experimental batch. Such adverse effects were also observed in PM10-mLOY associations. Moreover, the unweighted and weighted PRS presented significant negative associations with mLRR-Y (both P < 0.001). Participants with high PRS and high PM2.5 or PM10 exposure in the 28-day separately showed a 0.018 or 0.019 lower mLRR-Y level [β (95 %CI) = −0.018 (−0.023, −0.012) and − 0.019 (−0.025, −0.014), respectively, both P < 0.001], when compared to those with low PRS and low PM2.5 or PM10 exposure. We also observed joint effects of PM with smoking on exacerbated mLOY. This large study is the first to elucidate the impacts of PM2.5 exposure on mLOY, and provides key evidence regarding the interactive and joint effects of PM with genetic factors on mLOY, which may promote understanding of mLOY development, further modifying and increasing healthy aging in males.
[Display omitted]
●Effects of PM pollution and genetic factors on mLOY remain largely unknown.●High exposure to PM2.5 and PM10 were associated with elevated mLOY.●rs1122138, rs12448386, and rs56087422 can modified the PM-mLOY associations.●PM exposure with PRS and smoking take joint effects on mLOY.</description><subject>Aged</subject><subject>Air Pollutants - toxicity</subject><subject>Air Pollution - adverse effects</subject><subject>China</subject><subject>Chromosomes, Human, Y</subject><subject>Cohort Studies</subject><subject>Environmental Exposure - adverse effects</subject><subject>Genetic Risk Score</subject><subject>Humans</subject><subject>Male</subject><subject>Male population</subject><subject>Middle Aged</subject><subject>Mosaic loss of chromosome Y</subject><subject>Mosaicism</subject><subject>Particulate Matter - toxicity</subject><subject>PM10</subject><subject>PM2.5</subject><subject>Polygenic risk score</subject><subject>Risk Factors</subject><subject>Smoking</subject><issn>0304-3894</issn><issn>1873-3336</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuuFCEQhonReMajj6Bh6cIei4a-rYw5XpOT6OK4cEVoqJ6hpWEE2mR8D99XxhnduqJS-eqvFB8hTxlsGbD25byd9-rnovK2hlpsGRecNffIhvUdrzjn7X2yAQ6i4v0grsijlGYAYF0jHpIr3rdd3wHfkF-fVcxWr05lpCUtY6SH4NyabfAvTuVxh95qGm36RpMOEanyhi4hqdJ1ISUaJqr3MZRWWJB-pdbTxRrjsFI7NH_w4EwJXtDTqYA075G-CX43od9Vd6WYLdVhH2KmKa_m-Jg8mJRL-OTyXpMv797e3Xyobj-9_3jz-rbSnPFcmVHwsdYNNwwVjGaAoWUGNGKDAHoyohPNCKqt6xEQjWaoBRuFaSYcFDP8mjw_5x5i-L5iynKxSaNzymNYkyz_14uhqxkraHNGdSw3R5zkIdpFxaNkIE9G5CwvRuTJiDwbKXPPLivWcUHzb-qvggK8OgNYDv1hMcqkLXqNxkbUWZpg_7PiN4nhoyE</recordid><startdate>20240605</startdate><enddate>20240605</enddate><creator>Guan, Xin</creator><creator>Meng, Xia</creator><creator>Zhong, Guorong</creator><creator>Zhang, Zirui</creator><creator>Wang, Chenming</creator><creator>Xiao, Yang</creator><creator>Fu, Ming</creator><creator>Zhao, Hui</creator><creator>Zhou, Yuhan</creator><creator>Hong, Shiru</creator><creator>Xu, Xuedan</creator><creator>Bai, Yansen</creator><creator>Kan, Haidong</creator><creator>Chen, Renjie</creator><creator>Wu, Tangchun</creator><creator>Guo, Huan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240605</creationdate><title>Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study</title><author>Guan, Xin ; Meng, Xia ; Zhong, Guorong ; Zhang, Zirui ; Wang, Chenming ; Xiao, Yang ; Fu, Ming ; Zhao, Hui ; Zhou, Yuhan ; Hong, Shiru ; Xu, Xuedan ; Bai, Yansen ; Kan, Haidong ; Chen, Renjie ; Wu, Tangchun ; Guo, Huan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-db43b2c53d1ea0bd90961d0cee5e00cfd4745b0a622b0eedc1ec41b4d5fe9a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Air Pollutants - toxicity</topic><topic>Air Pollution - adverse effects</topic><topic>China</topic><topic>Chromosomes, Human, Y</topic><topic>Cohort Studies</topic><topic>Environmental Exposure - adverse effects</topic><topic>Genetic Risk Score</topic><topic>Humans</topic><topic>Male</topic><topic>Male population</topic><topic>Middle Aged</topic><topic>Mosaic loss of chromosome Y</topic><topic>Mosaicism</topic><topic>Particulate Matter - toxicity</topic><topic>PM10</topic><topic>PM2.5</topic><topic>Polygenic risk score</topic><topic>Risk Factors</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Xin</creatorcontrib><creatorcontrib>Meng, Xia</creatorcontrib><creatorcontrib>Zhong, Guorong</creatorcontrib><creatorcontrib>Zhang, Zirui</creatorcontrib><creatorcontrib>Wang, Chenming</creatorcontrib><creatorcontrib>Xiao, Yang</creatorcontrib><creatorcontrib>Fu, Ming</creatorcontrib><creatorcontrib>Zhao, Hui</creatorcontrib><creatorcontrib>Zhou, Yuhan</creatorcontrib><creatorcontrib>Hong, Shiru</creatorcontrib><creatorcontrib>Xu, Xuedan</creatorcontrib><creatorcontrib>Bai, Yansen</creatorcontrib><creatorcontrib>Kan, Haidong</creatorcontrib><creatorcontrib>Chen, Renjie</creatorcontrib><creatorcontrib>Wu, Tangchun</creatorcontrib><creatorcontrib>Guo, Huan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Xin</au><au>Meng, Xia</au><au>Zhong, Guorong</au><au>Zhang, Zirui</au><au>Wang, Chenming</au><au>Xiao, Yang</au><au>Fu, Ming</au><au>Zhao, Hui</au><au>Zhou, Yuhan</au><au>Hong, Shiru</au><au>Xu, Xuedan</au><au>Bai, Yansen</au><au>Kan, Haidong</au><au>Chen, Renjie</au><au>Wu, Tangchun</au><au>Guo, Huan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2024-06-05</date><risdate>2024</risdate><volume>471</volume><spage>134315</spage><pages>134315-</pages><artnum>134315</artnum><issn>0304-3894</issn><issn>1873-3336</issn><eissn>1873-3336</eissn><abstract>Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome instability. PM exposure is a major health concern worldwide, but its effects with genetic factors on mLOY has never been investigated. Here we explored the associations of PM2.5 and PM10 exposure with mLOY of 10,158 males measured via signal intensity of 2186 probes in male-specific chromosome-Y region from Illumina array data. The interactive and joint effects of PM2.5 and PM10 with genetic factors and smoking on mLOY were further evaluated. Compared with the lowest tertiles of PM2.5 levels in each exposure window, the highest tertiles in the same day, 7-, 14-, 21-, and 28-day showed a 0.005, 0.006, 0.007, 0.007, and 0.006 decrease in mLRR-Y, respectively (all P < 0.05), with adjustment for age, BMI, smoking pack-years, alcohol drinking status, physical activity, education levels, season of blood draw, and experimental batch. Such adverse effects were also observed in PM10-mLOY associations. Moreover, the unweighted and weighted PRS presented significant negative associations with mLRR-Y (both P < 0.001). Participants with high PRS and high PM2.5 or PM10 exposure in the 28-day separately showed a 0.018 or 0.019 lower mLRR-Y level [β (95 %CI) = −0.018 (−0.023, −0.012) and − 0.019 (−0.025, −0.014), respectively, both P < 0.001], when compared to those with low PRS and low PM2.5 or PM10 exposure. We also observed joint effects of PM with smoking on exacerbated mLOY. This large study is the first to elucidate the impacts of PM2.5 exposure on mLOY, and provides key evidence regarding the interactive and joint effects of PM with genetic factors on mLOY, which may promote understanding of mLOY development, further modifying and increasing healthy aging in males.
[Display omitted]
●Effects of PM pollution and genetic factors on mLOY remain largely unknown.●High exposure to PM2.5 and PM10 were associated with elevated mLOY.●rs1122138, rs12448386, and rs56087422 can modified the PM-mLOY associations.●PM exposure with PRS and smoking take joint effects on mLOY.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38678703</pmid><doi>10.1016/j.jhazmat.2024.134315</doi></addata></record> |
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| subjects | Aged Air Pollutants - toxicity Air Pollution - adverse effects China Chromosomes, Human, Y Cohort Studies Environmental Exposure - adverse effects Genetic Risk Score Humans Male Male population Middle Aged Mosaic loss of chromosome Y Mosaicism Particulate Matter - toxicity PM10 PM2.5 Polygenic risk score Risk Factors Smoking |
| title | Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study |
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