Bioprocess in‐line monitoring and control using Raman spectroscopy and Indirect Hard Modeling (IHM)

Process in‐line monitoring and control are crucial to optimize the productivity of bioprocesses. A frequently applied Process Analytical Technology (PAT) tool for bioprocess in‐line monitoring is Raman spectroscopy. However, evaluating bioprocess Raman spectra is complex and calibrating state‐of‐the...

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Veröffentlicht in:	Biotechnology and bioengineering 2024-07, Vol.121 (7), p.2225-2233
Hauptverfasser:	Müller, David Heinrich, Börger, Marieke, Thien, Julia, Koß, Hans‐Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	bioprocess Bioreactors Calibration Ethanol Ethanol - analysis Ethanol - metabolism Fermentation Glucose Glucose - analysis Glucose - metabolism Indirect Hard Modeling (IHM) in‐line monitoring and control Models, Biological Monitoring Prediction models Process Analytical Technology (PAT) Process control Process controls Raman spectra Raman spectroscopy Saccharomyces cerevisiae - metabolism Spectroscopy Spectrum analysis Spectrum Analysis, Raman - methods Statistical models Technology assessment Yeasts
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