Psilocybin promotes neuroplasticity and induces rapid and sustained antidepressant-like effects in mice

Background: Psilocybin offers new hope for treating mood disorders due to its rapid and sustained antidepressant effects, as standard medications require weeks or months to exert their effects. However, the mechanisms underlying this action of psilocybin have not been identified. Aims: To investigat...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2024-05, Vol.38 (5), p.489-499
Hauptverfasser:	Zhao, Xiangting, Du, Yingjie, Yao, Yishan, Dai, Wei, Yin, Yongyu, Wang, Guyan, Li, Yunfeng, Zhang, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - pharmacology Behavior, Animal - drug effects Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Corticosterone Dendritic plasticity Dendritic spines Depression - drug therapy Disease Models, Animal Doublecortin Protein Hippocampal plasticity Hippocampus Hippocampus - drug effects Hippocampus - metabolism Male Mice Mice, Inbred C57BL Neurogenesis Neuronal Plasticity - drug effects Neuroplasticity Postsynaptic density proteins Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Psilocybin Psilocybin - pharmacology Psychedelic drugs Signal transduction Sucrose Synapsin Synaptic density TOR protein TOR Serine-Threonine Kinases - metabolism TrkB receptors
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