Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society
No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary functio...
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| Veröffentlicht in: | Respiratory investigation 2024-07, Vol.62 (4), p.572-579 |
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| creator | Kamata, Hirofumi Takamatsu, Kazufumi Fukunaga, Koichi Chubachi, Shotaro Nakagawara, Kensuke Namkoong, Ho Terai, Hideki Tanaka, Katsushi Sato, Susumu Hagiwara, Eri Takei, Reoto Kondoh, Yasuhiro Takazono, Takahiro Hashimoto, Midori Tasaka, Sadatomo Ohrui, Takashi Tanino, Yoshinori Mineshita, Masamichi Komase, Yuko Miyazaki, Kazuhito Nishikawa, Masanori Ando, Akira Kita, Hideo Ichihara, Eiki Ohshimo, Shinichiro Murata, Yoriyuki Ishida, Masayuki Kobayashi, Seiichi Uchida, Takahiro Tateno, Hiroki Ikari, Jun Terashima, Takeshi Kozu, Yutaka Tateishi, Tomoya Shinkai, Masaharu Sagara, Hironori To, Yasuo Ito, Yoko Yamamoto, Masaki Yamamoto, Yoshihiro Kita, Toshiyuki Ito, Yutaka Tomii, Keisuke Fujita, Yukio Funaki, Yoshihiro Yatera, Kazuhiro Yamasue, Mari Komiya, Kosaku Kozawa, Satoko Manabe, Hideaki Hozumi, Hironao Horiguchi, Tomoya Kitajima, Takamasa Nakano, Yasushi Nagaoka, Tetsutaro Hojo, Masayuki Ebihara, Akinori Kobayashi, Masayoshi Takayama, Koji Jinta, Torahiko Sawai, Toyomitsu Fukuda, Yuichi Kaneko, Takeshi Chin, Kazuo Ogura, Takashi Mukae, Hiroshi Ishii, Makoto Yokoyama, Akihito |
| description | No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT.
For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021. Disease severity was classified as moderateⅠ, moderate II, and severe, defined primarily according to the degree of respiratory failure. The data on post-COVID-19 conditions over 12 months, pulmonary function, and chest CT findings at 3 months were evaluated in this study. Additionally, the impact of COVID-19 severity on pulmonary sequelae, such as impaired diffusion capacity, restrictive pattern, and CT abnormalities, was also evaluated.
The most frequently reported post-COVID-19 conditions at 3 months after COVID-19 were muscle weakness, dyspnea, and fatigue (48.4%, 29.0%, and 24.7%, respectively). The frequency of symptoms gradually decreased over subsequent months. In pulmonary function tests at 3 months, the incidence of impaired diffusion capacity and restrictive pattern increased depending on disease severity. There also were differences in the presence of chest CT abnormalities at the 3 months, which was markedly correlated with the severity.
We reported a comprehensive analysis of post-COVID-19 condition, pulmonary function, and chest CT abnormalities in Japanese patients with COVID-19. The findings of this study will serve as valuable reference data for future post-COVID-19 condition research in Japan. |
| doi_str_mv | 10.1016/j.resinv.2024.02.009 |
| format | Article |
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For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021. Disease severity was classified as moderateⅠ, moderate II, and severe, defined primarily according to the degree of respiratory failure. The data on post-COVID-19 conditions over 12 months, pulmonary function, and chest CT findings at 3 months were evaluated in this study. Additionally, the impact of COVID-19 severity on pulmonary sequelae, such as impaired diffusion capacity, restrictive pattern, and CT abnormalities, was also evaluated.
The most frequently reported post-COVID-19 conditions at 3 months after COVID-19 were muscle weakness, dyspnea, and fatigue (48.4%, 29.0%, and 24.7%, respectively). The frequency of symptoms gradually decreased over subsequent months. In pulmonary function tests at 3 months, the incidence of impaired diffusion capacity and restrictive pattern increased depending on disease severity. There also were differences in the presence of chest CT abnormalities at the 3 months, which was markedly correlated with the severity.
We reported a comprehensive analysis of post-COVID-19 condition, pulmonary function, and chest CT abnormalities in Japanese patients with COVID-19. The findings of this study will serve as valuable reference data for future post-COVID-19 condition research in Japan.</description><identifier>ISSN: 2212-5345</identifier><identifier>ISSN: 2212-5353</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2024.02.009</identifier><identifier>PMID: 38669898</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Chest CT ; Cohort Studies ; COVID-19 - complications ; COVID-19 - diagnostic imaging ; COVID-19 - epidemiology ; COVID-19 - physiopathology ; Dyspnea - etiology ; Dyspnea - physiopathology ; East Asian People ; Female ; Humans ; Japan - epidemiology ; Lung - diagnostic imaging ; Lung - physiopathology ; Male ; Middle Aged ; Patient Discharge ; Post-COVID-19 conditions ; Prospective Studies ; Pulmonary function test ; Pulmonary sequelae ; Respiratory Function Tests ; SARS-CoV-2 ; Severity of Illness Index ; Societies, Medical ; Time Factors ; Tomography, X-Ray Computed</subject><ispartof>Respiratory investigation, 2024-07, Vol.62 (4), p.572-579</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-a707348c6a336d4223e59ce4cb9154cf112fc70dbbf1e22f00452c52024fc7c73</cites><orcidid>0000-0001-7750-4328 ; 0000-0002-4811-175X ; 0000-0003-4396-1664 ; 0000-0003-2384-601X ; 0000-0003-3061-1489 ; 0000-0003-4861-4143 ; 0000-0003-1698-2304 ; 0000-0001-6158-7683 ; 0000-0003-4223-6794 ; 0000-0002-0696-5386 ; 0000-0003-3578-3351 ; 0000-0002-9626-1090 ; 0000-0002-0099-4696 ; 0000-0002-8697-8557 ; 0000-0001-5402-3185 ; 0000-0003-4472-3625 ; 0000-0002-8679-1661 ; 0000-0002-1011-7478 ; 0000-0002-9595-9657 ; 0000-0003-1347-3395 ; 0000-0002-0453-1242 ; 0000-0001-6181-4284 ; 0000-0002-4308-2275 ; 0000-0002-4012-2518 ; 0000-0001-7251-659X ; 0000-0002-1118-1930</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38669898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamata, Hirofumi</creatorcontrib><creatorcontrib>Takamatsu, Kazufumi</creatorcontrib><creatorcontrib>Fukunaga, Koichi</creatorcontrib><creatorcontrib>Chubachi, Shotaro</creatorcontrib><creatorcontrib>Nakagawara, Kensuke</creatorcontrib><creatorcontrib>Namkoong, Ho</creatorcontrib><creatorcontrib>Terai, Hideki</creatorcontrib><creatorcontrib>Tanaka, Katsushi</creatorcontrib><creatorcontrib>Sato, Susumu</creatorcontrib><creatorcontrib>Hagiwara, Eri</creatorcontrib><creatorcontrib>Takei, Reoto</creatorcontrib><creatorcontrib>Kondoh, Yasuhiro</creatorcontrib><creatorcontrib>Takazono, Takahiro</creatorcontrib><creatorcontrib>Hashimoto, Midori</creatorcontrib><creatorcontrib>Tasaka, Sadatomo</creatorcontrib><creatorcontrib>Ohrui, Takashi</creatorcontrib><creatorcontrib>Tanino, Yoshinori</creatorcontrib><creatorcontrib>Mineshita, Masamichi</creatorcontrib><creatorcontrib>Komase, Yuko</creatorcontrib><creatorcontrib>Miyazaki, Kazuhito</creatorcontrib><creatorcontrib>Nishikawa, Masanori</creatorcontrib><creatorcontrib>Ando, Akira</creatorcontrib><creatorcontrib>Kita, Hideo</creatorcontrib><creatorcontrib>Ichihara, Eiki</creatorcontrib><creatorcontrib>Ohshimo, Shinichiro</creatorcontrib><creatorcontrib>Murata, Yoriyuki</creatorcontrib><creatorcontrib>Ishida, Masayuki</creatorcontrib><creatorcontrib>Kobayashi, Seiichi</creatorcontrib><creatorcontrib>Uchida, Takahiro</creatorcontrib><creatorcontrib>Tateno, Hiroki</creatorcontrib><creatorcontrib>Ikari, Jun</creatorcontrib><creatorcontrib>Terashima, Takeshi</creatorcontrib><creatorcontrib>Kozu, Yutaka</creatorcontrib><creatorcontrib>Tateishi, Tomoya</creatorcontrib><creatorcontrib>Shinkai, Masaharu</creatorcontrib><creatorcontrib>Sagara, Hironori</creatorcontrib><creatorcontrib>To, Yasuo</creatorcontrib><creatorcontrib>Ito, Yoko</creatorcontrib><creatorcontrib>Yamamoto, Masaki</creatorcontrib><creatorcontrib>Yamamoto, Yoshihiro</creatorcontrib><creatorcontrib>Kita, Toshiyuki</creatorcontrib><creatorcontrib>Ito, Yutaka</creatorcontrib><creatorcontrib>Tomii, Keisuke</creatorcontrib><creatorcontrib>Fujita, Yukio</creatorcontrib><creatorcontrib>Funaki, Yoshihiro</creatorcontrib><creatorcontrib>Yatera, Kazuhiro</creatorcontrib><creatorcontrib>Yamasue, Mari</creatorcontrib><creatorcontrib>Komiya, Kosaku</creatorcontrib><creatorcontrib>Kozawa, Satoko</creatorcontrib><creatorcontrib>Manabe, Hideaki</creatorcontrib><creatorcontrib>Hozumi, Hironao</creatorcontrib><creatorcontrib>Horiguchi, Tomoya</creatorcontrib><creatorcontrib>Kitajima, Takamasa</creatorcontrib><creatorcontrib>Nakano, Yasushi</creatorcontrib><creatorcontrib>Nagaoka, Tetsutaro</creatorcontrib><creatorcontrib>Hojo, Masayuki</creatorcontrib><creatorcontrib>Ebihara, Akinori</creatorcontrib><creatorcontrib>Kobayashi, Masayoshi</creatorcontrib><creatorcontrib>Takayama, Koji</creatorcontrib><creatorcontrib>Jinta, Torahiko</creatorcontrib><creatorcontrib>Sawai, Toyomitsu</creatorcontrib><creatorcontrib>Fukuda, Yuichi</creatorcontrib><creatorcontrib>Kaneko, Takeshi</creatorcontrib><creatorcontrib>Chin, Kazuo</creatorcontrib><creatorcontrib>Ogura, Takashi</creatorcontrib><creatorcontrib>Mukae, Hiroshi</creatorcontrib><creatorcontrib>Ishii, Makoto</creatorcontrib><creatorcontrib>Yokoyama, Akihito</creatorcontrib><title>Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society</title><title>Respiratory investigation</title><addtitle>Respir Investig</addtitle><description>No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT.
For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021. Disease severity was classified as moderateⅠ, moderate II, and severe, defined primarily according to the degree of respiratory failure. The data on post-COVID-19 conditions over 12 months, pulmonary function, and chest CT findings at 3 months were evaluated in this study. Additionally, the impact of COVID-19 severity on pulmonary sequelae, such as impaired diffusion capacity, restrictive pattern, and CT abnormalities, was also evaluated.
The most frequently reported post-COVID-19 conditions at 3 months after COVID-19 were muscle weakness, dyspnea, and fatigue (48.4%, 29.0%, and 24.7%, respectively). The frequency of symptoms gradually decreased over subsequent months. In pulmonary function tests at 3 months, the incidence of impaired diffusion capacity and restrictive pattern increased depending on disease severity. There also were differences in the presence of chest CT abnormalities at the 3 months, which was markedly correlated with the severity.
We reported a comprehensive analysis of post-COVID-19 condition, pulmonary function, and chest CT abnormalities in Japanese patients with COVID-19. The findings of this study will serve as valuable reference data for future post-COVID-19 condition research in Japan.</description><subject>Aged</subject><subject>Chest CT</subject><subject>Cohort Studies</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - diagnostic imaging</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - physiopathology</subject><subject>Dyspnea - etiology</subject><subject>Dyspnea - physiopathology</subject><subject>East Asian People</subject><subject>Female</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Discharge</subject><subject>Post-COVID-19 conditions</subject><subject>Prospective Studies</subject><subject>Pulmonary function test</subject><subject>Pulmonary sequelae</subject><subject>Respiratory Function Tests</subject><subject>SARS-CoV-2</subject><subject>Severity of Illness Index</subject><subject>Societies, Medical</subject><subject>Time Factors</subject><subject>Tomography, X-Ray 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function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society</title><author>Kamata, Hirofumi ; Takamatsu, Kazufumi ; Fukunaga, Koichi ; Chubachi, Shotaro ; Nakagawara, Kensuke ; Namkoong, Ho ; Terai, Hideki ; Tanaka, Katsushi ; Sato, Susumu ; Hagiwara, Eri ; Takei, Reoto ; Kondoh, Yasuhiro ; Takazono, Takahiro ; Hashimoto, Midori ; Tasaka, Sadatomo ; Ohrui, Takashi ; Tanino, Yoshinori ; Mineshita, Masamichi ; Komase, Yuko ; Miyazaki, Kazuhito ; Nishikawa, Masanori ; Ando, Akira ; Kita, Hideo ; Ichihara, Eiki ; Ohshimo, Shinichiro ; Murata, Yoriyuki ; Ishida, Masayuki ; Kobayashi, Seiichi ; Uchida, Takahiro ; Tateno, Hiroki ; Ikari, Jun ; Terashima, Takeshi ; Kozu, Yutaka ; Tateishi, Tomoya ; Shinkai, Masaharu ; Sagara, Hironori ; To, Yasuo ; Ito, Yoko ; Yamamoto, Masaki ; Yamamoto, Yoshihiro ; Kita, Toshiyuki ; Ito, Yutaka ; Tomii, Keisuke ; Fujita, Yukio ; Funaki, Yoshihiro ; Yatera, Kazuhiro ; Yamasue, Mari ; Komiya, Kosaku ; Kozawa, Satoko ; Manabe, Hideaki ; Hozumi, Hironao ; Horiguchi, Tomoya ; Kitajima, Takamasa ; Nakano, Yasushi ; Nagaoka, Tetsutaro ; Hojo, Masayuki ; Ebihara, Akinori ; Kobayashi, Masayoshi ; Takayama, Koji ; Jinta, Torahiko ; Sawai, Toyomitsu ; Fukuda, Yuichi ; Kaneko, Takeshi ; Chin, Kazuo ; Ogura, Takashi ; Mukae, Hiroshi ; Ishii, Makoto ; Yokoyama, Akihito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-a707348c6a336d4223e59ce4cb9154cf112fc70dbbf1e22f00452c52024fc7c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Chest CT</topic><topic>Cohort Studies</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - diagnostic imaging</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - physiopathology</topic><topic>Dyspnea - etiology</topic><topic>Dyspnea - physiopathology</topic><topic>East Asian People</topic><topic>Female</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Discharge</topic><topic>Post-COVID-19 conditions</topic><topic>Prospective Studies</topic><topic>Pulmonary function test</topic><topic>Pulmonary sequelae</topic><topic>Respiratory Function Tests</topic><topic>SARS-CoV-2</topic><topic>Severity of Illness Index</topic><topic>Societies, Medical</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamata, Hirofumi</creatorcontrib><creatorcontrib>Takamatsu, Kazufumi</creatorcontrib><creatorcontrib>Fukunaga, Koichi</creatorcontrib><creatorcontrib>Chubachi, Shotaro</creatorcontrib><creatorcontrib>Nakagawara, Kensuke</creatorcontrib><creatorcontrib>Namkoong, Ho</creatorcontrib><creatorcontrib>Terai, Hideki</creatorcontrib><creatorcontrib>Tanaka, Katsushi</creatorcontrib><creatorcontrib>Sato, Susumu</creatorcontrib><creatorcontrib>Hagiwara, Eri</creatorcontrib><creatorcontrib>Takei, Reoto</creatorcontrib><creatorcontrib>Kondoh, Yasuhiro</creatorcontrib><creatorcontrib>Takazono, Takahiro</creatorcontrib><creatorcontrib>Hashimoto, Midori</creatorcontrib><creatorcontrib>Tasaka, Sadatomo</creatorcontrib><creatorcontrib>Ohrui, Takashi</creatorcontrib><creatorcontrib>Tanino, Yoshinori</creatorcontrib><creatorcontrib>Mineshita, Masamichi</creatorcontrib><creatorcontrib>Komase, Yuko</creatorcontrib><creatorcontrib>Miyazaki, Kazuhito</creatorcontrib><creatorcontrib>Nishikawa, Masanori</creatorcontrib><creatorcontrib>Ando, Akira</creatorcontrib><creatorcontrib>Kita, Hideo</creatorcontrib><creatorcontrib>Ichihara, Eiki</creatorcontrib><creatorcontrib>Ohshimo, Shinichiro</creatorcontrib><creatorcontrib>Murata, Yoriyuki</creatorcontrib><creatorcontrib>Ishida, Masayuki</creatorcontrib><creatorcontrib>Kobayashi, Seiichi</creatorcontrib><creatorcontrib>Uchida, Takahiro</creatorcontrib><creatorcontrib>Tateno, Hiroki</creatorcontrib><creatorcontrib>Ikari, Jun</creatorcontrib><creatorcontrib>Terashima, Takeshi</creatorcontrib><creatorcontrib>Kozu, Yutaka</creatorcontrib><creatorcontrib>Tateishi, Tomoya</creatorcontrib><creatorcontrib>Shinkai, Masaharu</creatorcontrib><creatorcontrib>Sagara, Hironori</creatorcontrib><creatorcontrib>To, Yasuo</creatorcontrib><creatorcontrib>Ito, Yoko</creatorcontrib><creatorcontrib>Yamamoto, Masaki</creatorcontrib><creatorcontrib>Yamamoto, Yoshihiro</creatorcontrib><creatorcontrib>Kita, Toshiyuki</creatorcontrib><creatorcontrib>Ito, Yutaka</creatorcontrib><creatorcontrib>Tomii, Keisuke</creatorcontrib><creatorcontrib>Fujita, Yukio</creatorcontrib><creatorcontrib>Funaki, Yoshihiro</creatorcontrib><creatorcontrib>Yatera, Kazuhiro</creatorcontrib><creatorcontrib>Yamasue, Mari</creatorcontrib><creatorcontrib>Komiya, Kosaku</creatorcontrib><creatorcontrib>Kozawa, Satoko</creatorcontrib><creatorcontrib>Manabe, Hideaki</creatorcontrib><creatorcontrib>Hozumi, Hironao</creatorcontrib><creatorcontrib>Horiguchi, Tomoya</creatorcontrib><creatorcontrib>Kitajima, Takamasa</creatorcontrib><creatorcontrib>Nakano, Yasushi</creatorcontrib><creatorcontrib>Nagaoka, Tetsutaro</creatorcontrib><creatorcontrib>Hojo, Masayuki</creatorcontrib><creatorcontrib>Ebihara, Akinori</creatorcontrib><creatorcontrib>Kobayashi, Masayoshi</creatorcontrib><creatorcontrib>Takayama, Koji</creatorcontrib><creatorcontrib>Jinta, Torahiko</creatorcontrib><creatorcontrib>Sawai, Toyomitsu</creatorcontrib><creatorcontrib>Fukuda, Yuichi</creatorcontrib><creatorcontrib>Kaneko, Takeshi</creatorcontrib><creatorcontrib>Chin, Kazuo</creatorcontrib><creatorcontrib>Ogura, Takashi</creatorcontrib><creatorcontrib>Mukae, Hiroshi</creatorcontrib><creatorcontrib>Ishii, Makoto</creatorcontrib><creatorcontrib>Yokoyama, Akihito</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamata, Hirofumi</au><au>Takamatsu, Kazufumi</au><au>Fukunaga, Koichi</au><au>Chubachi, Shotaro</au><au>Nakagawara, Kensuke</au><au>Namkoong, Ho</au><au>Terai, Hideki</au><au>Tanaka, Katsushi</au><au>Sato, Susumu</au><au>Hagiwara, Eri</au><au>Takei, Reoto</au><au>Kondoh, Yasuhiro</au><au>Takazono, Takahiro</au><au>Hashimoto, Midori</au><au>Tasaka, Sadatomo</au><au>Ohrui, Takashi</au><au>Tanino, Yoshinori</au><au>Mineshita, Masamichi</au><au>Komase, Yuko</au><au>Miyazaki, Kazuhito</au><au>Nishikawa, Masanori</au><au>Ando, Akira</au><au>Kita, Hideo</au><au>Ichihara, Eiki</au><au>Ohshimo, Shinichiro</au><au>Murata, Yoriyuki</au><au>Ishida, Masayuki</au><au>Kobayashi, Seiichi</au><au>Uchida, Takahiro</au><au>Tateno, Hiroki</au><au>Ikari, Jun</au><au>Terashima, Takeshi</au><au>Kozu, Yutaka</au><au>Tateishi, Tomoya</au><au>Shinkai, Masaharu</au><au>Sagara, Hironori</au><au>To, Yasuo</au><au>Ito, Yoko</au><au>Yamamoto, Masaki</au><au>Yamamoto, Yoshihiro</au><au>Kita, Toshiyuki</au><au>Ito, Yutaka</au><au>Tomii, Keisuke</au><au>Fujita, Yukio</au><au>Funaki, Yoshihiro</au><au>Yatera, Kazuhiro</au><au>Yamasue, Mari</au><au>Komiya, Kosaku</au><au>Kozawa, Satoko</au><au>Manabe, Hideaki</au><au>Hozumi, Hironao</au><au>Horiguchi, Tomoya</au><au>Kitajima, Takamasa</au><au>Nakano, Yasushi</au><au>Nagaoka, Tetsutaro</au><au>Hojo, Masayuki</au><au>Ebihara, Akinori</au><au>Kobayashi, Masayoshi</au><au>Takayama, Koji</au><au>Jinta, Torahiko</au><au>Sawai, Toyomitsu</au><au>Fukuda, Yuichi</au><au>Kaneko, Takeshi</au><au>Chin, Kazuo</au><au>Ogura, Takashi</au><au>Mukae, Hiroshi</au><au>Ishii, Makoto</au><au>Yokoyama, Akihito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society</atitle><jtitle>Respiratory investigation</jtitle><addtitle>Respir Investig</addtitle><date>2024-07</date><risdate>2024</risdate><volume>62</volume><issue>4</issue><spage>572</spage><epage>579</epage><pages>572-579</pages><issn>2212-5345</issn><issn>2212-5353</issn><eissn>2212-5353</eissn><abstract>No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT.
For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021. Disease severity was classified as moderateⅠ, moderate II, and severe, defined primarily according to the degree of respiratory failure. The data on post-COVID-19 conditions over 12 months, pulmonary function, and chest CT findings at 3 months were evaluated in this study. Additionally, the impact of COVID-19 severity on pulmonary sequelae, such as impaired diffusion capacity, restrictive pattern, and CT abnormalities, was also evaluated.
The most frequently reported post-COVID-19 conditions at 3 months after COVID-19 were muscle weakness, dyspnea, and fatigue (48.4%, 29.0%, and 24.7%, respectively). The frequency of symptoms gradually decreased over subsequent months. In pulmonary function tests at 3 months, the incidence of impaired diffusion capacity and restrictive pattern increased depending on disease severity. There also were differences in the presence of chest CT abnormalities at the 3 months, which was markedly correlated with the severity.
We reported a comprehensive analysis of post-COVID-19 condition, pulmonary function, and chest CT abnormalities in Japanese patients with COVID-19. The findings of this study will serve as valuable reference data for future post-COVID-19 condition research in Japan.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38669898</pmid><doi>10.1016/j.resinv.2024.02.009</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7750-4328</orcidid><orcidid>https://orcid.org/0000-0002-4811-175X</orcidid><orcidid>https://orcid.org/0000-0003-4396-1664</orcidid><orcidid>https://orcid.org/0000-0003-2384-601X</orcidid><orcidid>https://orcid.org/0000-0003-3061-1489</orcidid><orcidid>https://orcid.org/0000-0003-4861-4143</orcidid><orcidid>https://orcid.org/0000-0003-1698-2304</orcidid><orcidid>https://orcid.org/0000-0001-6158-7683</orcidid><orcidid>https://orcid.org/0000-0003-4223-6794</orcidid><orcidid>https://orcid.org/0000-0002-0696-5386</orcidid><orcidid>https://orcid.org/0000-0003-3578-3351</orcidid><orcidid>https://orcid.org/0000-0002-9626-1090</orcidid><orcidid>https://orcid.org/0000-0002-0099-4696</orcidid><orcidid>https://orcid.org/0000-0002-8697-8557</orcidid><orcidid>https://orcid.org/0000-0001-5402-3185</orcidid><orcidid>https://orcid.org/0000-0003-4472-3625</orcidid><orcidid>https://orcid.org/0000-0002-8679-1661</orcidid><orcidid>https://orcid.org/0000-0002-1011-7478</orcidid><orcidid>https://orcid.org/0000-0002-9595-9657</orcidid><orcidid>https://orcid.org/0000-0003-1347-3395</orcidid><orcidid>https://orcid.org/0000-0002-0453-1242</orcidid><orcidid>https://orcid.org/0000-0001-6181-4284</orcidid><orcidid>https://orcid.org/0000-0002-4308-2275</orcidid><orcidid>https://orcid.org/0000-0002-4012-2518</orcidid><orcidid>https://orcid.org/0000-0001-7251-659X</orcidid><orcidid>https://orcid.org/0000-0002-1118-1930</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2212-5345 |
| ispartof | Respiratory investigation, 2024-07, Vol.62 (4), p.572-579 |
| issn | 2212-5345 2212-5353 2212-5353 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3047952945 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Chest CT Cohort Studies COVID-19 - complications COVID-19 - diagnostic imaging COVID-19 - epidemiology COVID-19 - physiopathology Dyspnea - etiology Dyspnea - physiopathology East Asian People Female Humans Japan - epidemiology Lung - diagnostic imaging Lung - physiopathology Male Middle Aged Patient Discharge Post-COVID-19 conditions Prospective Studies Pulmonary function test Pulmonary sequelae Respiratory Function Tests SARS-CoV-2 Severity of Illness Index Societies, Medical Time Factors Tomography, X-Ray Computed |
| title | Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society |
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