Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice

Free labile hemin acts as a damage-associated molecular pattern during acute and chronic hemolysis and muscle injury, supporting platelet activation and thrombosis. To investigate the anti-thrombotic potential of hydroxychloroquine on hemolysis-induced platelet activation and arterial thrombosis. Th...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2024-07, Vol.22 (7), p.2018-2026
Hauptverfasser:	Bourne, Joshua H., Perrella, Gina, El-Awaisi, Juma, Terry, Lauren V., Tinkova, Veronika, Hogg, Rebecca L., Gant, Poppy, Grygielska, Beata, Kalia, Neena, Kavanagh, Dean, Brill, Alexander, Dimitrov, Jordan D., Watson, Steve P., Rayes, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - drug effects Blood Platelets - metabolism Chlorides Disease Models, Animal Erythrocytes - drug effects Erythrocytes - metabolism Ferric Compounds hemin Hemin - pharmacology hemolysis Hemolysis - drug effects Humans hydroxychloroquine Hydroxychloroquine - pharmacology Lung - blood supply Lung - drug effects Male Mice Mice, Inbred C57BL Platelet Activation - drug effects Platelet Aggregation - drug effects platelets thrombosis Thrombosis - blood Thrombosis - drug therapy von Willebrand Factor - metabolism
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