The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors

Tipifarnib is the only targeted therapy breakthrough for -mutant ( mt) recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). The molecular profiles of mt cancers are difficult to explore given the low frequency of mt. This study aims to understand the molecular co-alterations, immun...

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Veröffentlicht in:	Cancers 2024-04, Vol.16 (8), p.1572
Hauptverfasser:	Kareff, Samuel A, Trabolsi, Asaad, Krause, Harris B, Samec, Timothy, Elliott, Andrew, Rodriguez, Estelamari, Olazagasti, Coral, Watson, Dionysios C, Bustos, Matias A, Hoon, Dave S B, Graff, Stephanie L, Antonarakis, Emmanuel S, Goel, Sanjay, Sledge, George, Lopes, Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Breast cancer Breast carcinoma CD8 antigen Clinical outcomes ErbB-2 protein Genomes Genomics Head and neck carcinoma Kinases Life sciences Lung cancer Lymphocytes T Macrophages Melanoma Metastases Mutants Mutation Non-small cell lung carcinoma Precision medicine Proteins Small cell lung carcinoma Solid tumors Squamous cell carcinoma Transcriptomics Tumor microenvironment Tumors Urothelial cancer Urothelial carcinoma
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