Perioperative Evaluation of the Physical Quality of Life of Patients with Non-Small Cell Lung Cancer: A Prospective Study
Surgery is the most effective treatment for early-stage lung cancer; however, it poses a higher physical burden than other treatment options. Therefore, understanding the perioperative course of patients is important. Using the Short Form Health Survey 36, we prospectively measured the physical qual...
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| Veröffentlicht in: | Cancers 2024-04, Vol.16 (8), p.1527 |
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| creator | Fukai, Ryuta Nishida, Tomoki Sugimoto, Hideyasu Hibino, Makoto Horiuchi, Shigeto Kondo, Tetsuri Teshima, Shinichi Hirata, Masahiro Asou, Keiko Shimizu, Etsuko Saito, Yuichi Sakao, Yukinori |
| description | Surgery is the most effective treatment for early-stage lung cancer; however, it poses a higher physical burden than other treatment options. Therefore, understanding the perioperative course of patients is important. Using the Short Form Health Survey 36, we prospectively measured the physical quality of life of patients who underwent anatomical pulmonary resection for non-small cell lung cancer at Shonan Kamakura General Hospital, Kanagawa, Japan (n = 87). In the preoperative setting, patients who had lower performance status and lived alone had significantly worse physical quality of life scores on multivariate analysis (regression coefficient (95% confidence interval), -9.37 (-13.43--5.32) and -10.22 (-13.74--7.40), respectively,
< 0.0001 for both). At 6 months postoperatively, patients who stopped smoking within 1 year preoperatively (stopped smoking within 1 year vs. remote or never smokers, 41.0 ± 10.5 vs. 48.6 ± 7.2,
= 0.002), had lower performance status (0 vs. 1-2, 49.3 ± 6.6 vs. 38.6 ± 9.6,
< 0.0001), lived alone (living alone vs. living with somebody, 41.6 ± 9.7 vs. 48.1 ± 7.9,
= 0.021), and had higher comorbid burden (Charlson comorbidity index |
| doi_str_mv | 10.3390/cancers16081527 |
| format | Article |
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< 0.0001 for both). At 6 months postoperatively, patients who stopped smoking within 1 year preoperatively (stopped smoking within 1 year vs. remote or never smokers, 41.0 ± 10.5 vs. 48.6 ± 7.2,
= 0.002), had lower performance status (0 vs. 1-2, 49.3 ± 6.6 vs. 38.6 ± 9.6,
< 0.0001), lived alone (living alone vs. living with somebody, 41.6 ± 9.7 vs. 48.1 ± 7.9,
= 0.021), and had higher comorbid burden (Charlson comorbidity index <3 vs. ≥3, 48.2 ± 6.9 vs. 39.1 ± 14.7,
= 0.003) had significantly worse physical quality of life scores on univariate analysis. More recent smoking (regression coefficient (95% confidence interval), -4.90 (-8.78-1.0),
= 0.014), lower performance status (8.90 (5.10-12.70),
< 0.0001), living alone (5.76 (1.39-10.13),
= 0.01), and higher comorbid burden (-6.94 (-11.78--2.10),
= 0.006) were significant independent predictors of worse postoperative physical quality of life on multivariate analysis. Therefore, patients with these conditions might need additional support to maintain their physical condition after anatomical lung cancer surgery.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16081527</identifier><identifier>PMID: 38672609</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Activities of daily living ; Cancer therapies ; Cigarette smoking ; Comorbidity ; Drug addiction ; Lung cancer ; Medical records ; Multivariate analysis ; Non-small cell lung carcinoma ; Older people ; Ostomy ; Patients ; Quality of life ; Questionnaires ; Small cell lung carcinoma ; Surgeons ; Surgery ; Thoracic surgery</subject><ispartof>Cancers, 2024-04, Vol.16 (8), p.1527</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c320t-9ede2562d2bd8ebb92e0fa561a906693d10cc4a34fc7de9d058467bfa3dd93783</cites><orcidid>0000-0002-2025-9226 ; 0000-0001-8483-7788 ; 0000-0003-1186-1693 ; 0000-0002-1638-5027</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38672609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukai, Ryuta</creatorcontrib><creatorcontrib>Nishida, Tomoki</creatorcontrib><creatorcontrib>Sugimoto, Hideyasu</creatorcontrib><creatorcontrib>Hibino, Makoto</creatorcontrib><creatorcontrib>Horiuchi, Shigeto</creatorcontrib><creatorcontrib>Kondo, Tetsuri</creatorcontrib><creatorcontrib>Teshima, Shinichi</creatorcontrib><creatorcontrib>Hirata, Masahiro</creatorcontrib><creatorcontrib>Asou, Keiko</creatorcontrib><creatorcontrib>Shimizu, Etsuko</creatorcontrib><creatorcontrib>Saito, Yuichi</creatorcontrib><creatorcontrib>Sakao, Yukinori</creatorcontrib><title>Perioperative Evaluation of the Physical Quality of Life of Patients with Non-Small Cell Lung Cancer: A Prospective Study</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Surgery is the most effective treatment for early-stage lung cancer; however, it poses a higher physical burden than other treatment options. Therefore, understanding the perioperative course of patients is important. Using the Short Form Health Survey 36, we prospectively measured the physical quality of life of patients who underwent anatomical pulmonary resection for non-small cell lung cancer at Shonan Kamakura General Hospital, Kanagawa, Japan (n = 87). In the preoperative setting, patients who had lower performance status and lived alone had significantly worse physical quality of life scores on multivariate analysis (regression coefficient (95% confidence interval), -9.37 (-13.43--5.32) and -10.22 (-13.74--7.40), respectively,
< 0.0001 for both). At 6 months postoperatively, patients who stopped smoking within 1 year preoperatively (stopped smoking within 1 year vs. remote or never smokers, 41.0 ± 10.5 vs. 48.6 ± 7.2,
= 0.002), had lower performance status (0 vs. 1-2, 49.3 ± 6.6 vs. 38.6 ± 9.6,
< 0.0001), lived alone (living alone vs. living with somebody, 41.6 ± 9.7 vs. 48.1 ± 7.9,
= 0.021), and had higher comorbid burden (Charlson comorbidity index <3 vs. ≥3, 48.2 ± 6.9 vs. 39.1 ± 14.7,
= 0.003) had significantly worse physical quality of life scores on univariate analysis. More recent smoking (regression coefficient (95% confidence interval), -4.90 (-8.78-1.0),
= 0.014), lower performance status (8.90 (5.10-12.70),
< 0.0001), living alone (5.76 (1.39-10.13),
= 0.01), and higher comorbid burden (-6.94 (-11.78--2.10),
= 0.006) were significant independent predictors of worse postoperative physical quality of life on multivariate analysis. Therefore, patients with these conditions might need additional support to maintain their physical condition after anatomical lung cancer surgery.</description><subject>Activities of daily living</subject><subject>Cancer therapies</subject><subject>Cigarette smoking</subject><subject>Comorbidity</subject><subject>Drug addiction</subject><subject>Lung cancer</subject><subject>Medical records</subject><subject>Multivariate analysis</subject><subject>Non-small cell lung carcinoma</subject><subject>Older people</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Small cell lung carcinoma</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Thoracic surgery</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkd1LwzAUxYMoKnPPvknAF1-q-WiTxjcZ8wOGTqbPJU1uXaVrZ9JO-t-builiHnIv4Zdzz-UgdErJJeeKXBldG3CeCpLShMk9dMyIZJEQKt7_0x-hsffvJBzOqRTyEB3xVEgmiDpG_Rxc2azB6bbcAJ5udNWFtqlxU-B2CXi-7H1pdIWfO12VbT-8z8oChjoPJNStx59lu8SPTR0tVrqq8ATCNevqNzz5tniNb_DcNX4N5nvKou1sf4IOCl15GO_qCL3eTl8m99Hs6e5hcjOLDGekjRRYYIlgluU2hTxXDEihE0G1ImE7bikxJtY8Loy0oCxJ0ljIvNDcWsVlykfoYqu7ds1HB77NVqU3waGuoel8xkksVUIJUQE9_4e-N52rg7uBEpKmSTwIXm0pE1byDops7cqVdn1GSTYEk_0LJvw42-l2-QrsL_8TA_8C9DGKeA</recordid><startdate>20240417</startdate><enddate>20240417</enddate><creator>Fukai, Ryuta</creator><creator>Nishida, Tomoki</creator><creator>Sugimoto, Hideyasu</creator><creator>Hibino, Makoto</creator><creator>Horiuchi, Shigeto</creator><creator>Kondo, Tetsuri</creator><creator>Teshima, Shinichi</creator><creator>Hirata, Masahiro</creator><creator>Asou, Keiko</creator><creator>Shimizu, Etsuko</creator><creator>Saito, Yuichi</creator><creator>Sakao, Yukinori</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2025-9226</orcidid><orcidid>https://orcid.org/0000-0001-8483-7788</orcidid><orcidid>https://orcid.org/0000-0003-1186-1693</orcidid><orcidid>https://orcid.org/0000-0002-1638-5027</orcidid></search><sort><creationdate>20240417</creationdate><title>Perioperative Evaluation of the Physical Quality of Life of Patients with Non-Small Cell Lung Cancer: A Prospective Study</title><author>Fukai, Ryuta ; 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however, it poses a higher physical burden than other treatment options. Therefore, understanding the perioperative course of patients is important. Using the Short Form Health Survey 36, we prospectively measured the physical quality of life of patients who underwent anatomical pulmonary resection for non-small cell lung cancer at Shonan Kamakura General Hospital, Kanagawa, Japan (n = 87). In the preoperative setting, patients who had lower performance status and lived alone had significantly worse physical quality of life scores on multivariate analysis (regression coefficient (95% confidence interval), -9.37 (-13.43--5.32) and -10.22 (-13.74--7.40), respectively,
< 0.0001 for both). At 6 months postoperatively, patients who stopped smoking within 1 year preoperatively (stopped smoking within 1 year vs. remote or never smokers, 41.0 ± 10.5 vs. 48.6 ± 7.2,
= 0.002), had lower performance status (0 vs. 1-2, 49.3 ± 6.6 vs. 38.6 ± 9.6,
< 0.0001), lived alone (living alone vs. living with somebody, 41.6 ± 9.7 vs. 48.1 ± 7.9,
= 0.021), and had higher comorbid burden (Charlson comorbidity index <3 vs. ≥3, 48.2 ± 6.9 vs. 39.1 ± 14.7,
= 0.003) had significantly worse physical quality of life scores on univariate analysis. More recent smoking (regression coefficient (95% confidence interval), -4.90 (-8.78-1.0),
= 0.014), lower performance status (8.90 (5.10-12.70),
< 0.0001), living alone (5.76 (1.39-10.13),
= 0.01), and higher comorbid burden (-6.94 (-11.78--2.10),
= 0.006) were significant independent predictors of worse postoperative physical quality of life on multivariate analysis. Therefore, patients with these conditions might need additional support to maintain their physical condition after anatomical lung cancer surgery.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38672609</pmid><doi>10.3390/cancers16081527</doi><orcidid>https://orcid.org/0000-0002-2025-9226</orcidid><orcidid>https://orcid.org/0000-0001-8483-7788</orcidid><orcidid>https://orcid.org/0000-0003-1186-1693</orcidid><orcidid>https://orcid.org/0000-0002-1638-5027</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Activities of daily living Cancer therapies Cigarette smoking Comorbidity Drug addiction Lung cancer Medical records Multivariate analysis Non-small cell lung carcinoma Older people Ostomy Patients Quality of life Questionnaires Small cell lung carcinoma Surgeons Surgery Thoracic surgery |
| title | Perioperative Evaluation of the Physical Quality of Life of Patients with Non-Small Cell Lung Cancer: A Prospective Study |
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