A Phase Ib Expansion Cohort Evaluating Aurora A Kinase Inhibitor Alisertib and Dual TORC1/2 Inhibitor Sapanisertib in Patients with Advanced Solid Tumors

This study further evaluated the safety and efficacy of the combination of alisertib and sapanisertib in an expansion cohort of patients, including a subset of patients with refractory pancreatic adenocarcinoma, with further evaluation of the pharmacodynamic characteristics of combination therapy. T...

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Veröffentlicht in:	Cancers 2024-04, Vol.16 (8), p.1456
Hauptverfasser:	Davis, S Lindsey, Messersmith, Wells A, Purcell, W Thomas, Lam, Elaine T, Corr, Bradley R, Leal, Alexis D, Lieu, Christopher H, O'Bryant, Cindy L, Smoots, Stephen G, Dus, Evan D, Jordan, Kimberly R, Serkova, Natalie J, Pitts, Todd M, Diamond, Jennifer R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenocarcinoma AKT protein Apoptosis Biopsy Breast cancer Cancer therapies Combination therapy Drug dosages Enzyme inhibitors Glucose monitoring Immune system Immunosuppressive agents Liver cancer Metastasis Neutropenia Pancreatic cancer Patients Pharmacodynamics Solid tumors Thrombocytopenia TOR protein Toxicity Tumors
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